Optimization of PVA-Arabic Gum–Honey-based Electrospun Nanofibers as Candidate Carrier for Peptide and Protein Delivery
Nanofibers dressing exhibit several advantageous characteristics for accelerating wound healing, such as its similar structure to the extracellular matrix (ECM), high surface area/volume ratio, high porosity and high loading capacity of drug. The nanofibers dressing which were prepared by the el...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universitas Indonesia
2019-08-01
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| Series: | Pharmaceutical Sciences and Research |
| Subjects: | |
| Online Access: | http://psr.ui.ac.id/index.php/journal/article/view/4552 |
| Summary: | Nanofibers dressing exhibit several advantageous characteristics for accelerating wound healing, such
as its similar structure to the extracellular matrix (ECM), high surface area/volume ratio, high porosity
and high loading capacity of drug. The nanofibers dressing which were prepared by the electrospinning
technique using combination of synthetic and natural polymer excipients capable of fulfilling the ideal
wound dressing criteria. This study aimed to develop nanofibers dressing prepared from polyvinyl
alcohol (PVA), Arabic gum (GA) and honey by electrospinning method. This study focused on the effect
of electrospinning parameters and the morphology of electrospun nanofibers of the blended solutions
made from PVA (9% w/v) – GA (1% w/v) and honey (at varied concentrations of 0;1;3% w/v) with or
without Triton X-100 (0.05% w/v). The effect of varied process parameters such as voltage and flow rate
in electrospinning was also investigated. The blended solutions with the various concentration of honey
at 0;1;3% w/v and Triton X-100 were named as FAt, FBt, and FCt, respectively, while the blended
solutions without Triton X-100, were named as FA, FB, and FC. The optimum electrospining parameter
were 18 KV and 5 µl/minute for FAt, FBt, and FCt; and 20 KV and 10 µl/minute for FA, FB, and FC.
Electrospun nanofibers of FAt, FBt, FCt showed smoother and more uniform fibers in comparison to the
nanofibers FA, FB, and FC. The average nanofibers diameter of FAt, FBt, FCt were 244±45; 266±45;
283±57 nm, respectively, while the average nanofibers diameter of FA, FB, FC was 406±140, 457±168,
594±204 nm, respectively. Higher concentration of honey increased the diameters of nanofibers. The
average nanofibers diameter of FAt, FBt, and FCt were within nanoscale in range of the ECM (50-500
nm), which were suitable for accelerating wound healing. Therefore, this study indicated that PVA-GAhoney
nanofibers dressing is suitable to be further developed as carrier for growth factors. |
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| ISSN: | 2407-2354 2477-0612 |