Immunophenotypic shifts during minimal residual evaluation in a case of leukemic form of anaplastic large cell lymphoma ALK+

Immunophenotypic shifts during minimal residual evaluation in a case of leukemic form of anaplastic large cell lymphoma ALK+

Abstract Background This study aims to describe immunophenotypic explorations at diagnosis and follow up of a pediatric patient with leukemic phase of ALK+ anaplastic large cell lymphoma (ALCL) by multiparametric flow cytometry (MFC). Case An 8‐color MFC combination of antibodies allowed to identify...

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Bibliographic Details
Main Authors: Maria Clara Canellas, Enrico Bruno‐Riscarolli, Cristiane S. Ferreira‐Facio, Daiana V. Lopes‐Alves, Vitor D. Botafogo, Deborah Sutter, Roberia M. Pontes, Marcelo G. P. Land, Cristiane Bedran Milito, Elaine Sobral daCosta
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Cancer Reports
Subjects:
anaplastic large cell lymphoma
minimal residual disease
multiparameter flow cytometry
Online Access:https://doi.org/10.1002/cnr2.1526
Description
Summary:Abstract Background This study aims to describe immunophenotypic explorations at diagnosis and follow up of a pediatric patient with leukemic phase of ALK+ anaplastic large cell lymphoma (ALCL) by multiparametric flow cytometry (MFC). Case An 8‐color MFC combination of antibodies allowed to identify neoplastic cells in concentrations until 0.02% during minimal residual disease (MRD) monitoring. Immunophenotypic shifts occurred in key markers as CD30, CD7, CD2, and CD5, however neoplastic cells were clearly discriminated from normal populations. Conclusion MFC can be a useful tool for ALCL diagnosis and MRD monitoring and may support therapeutic decisions.
ISSN:2573-8348

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