Sodium Gill Potential as a Tool to Monitor Valve Closure Behavior in Freshwater Clam Corbicula fluminea in Response to Copper
Valve closure behavior in freshwater clam Corbicula fluminea is a biologically sensitive endpoint. The purpose of this paper was to derive an electrophysiological response model of C. fluminea to assess copper (Cu)-sodium (Na) interactions in gill membrane, whereby valve closure behavior and Cu toxi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2008-09-01
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| Series: | Sensors |
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| Online Access: | http://www.mdpi.com/1424-8220/8/9/5250/ |
| _version_ | 1811184814164803584 |
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| author | Wei-Yu Chen Li-John Jou Chieh-Ming Lin Chung-Min Liao |
| author_facet | Wei-Yu Chen Li-John Jou Chieh-Ming Lin Chung-Min Liao |
| author_sort | Wei-Yu Chen |
| collection | DOAJ |
| description | Valve closure behavior in freshwater clam Corbicula fluminea is a biologically sensitive endpoint. The purpose of this paper was to derive an electrophysiological response model of C. fluminea to assess copper (Cu)-sodium (Na) interactions in gill membrane, whereby valve closure behavior and Cu toxicity could be monitored. The proposed model was based on the integration of Cu bioavailability, Na and Cu internalizations, and electrochemically-based gill potentials. Based on Na active transport under non-equilibrium conditions, predicted gill potential of -8.2 mV agreed reasonably well with published the measured transepithelial potential of -7 mV in C. fluminea. Our proposed framework captured the general features observed in model applications including: (i) 50% inhibitory Cu2+ activities for Na membrane potential (ENa) and uptake rate (JNa) were estimated to be 0.072 and 0.043 mM, respectively, with a stoichiometry of 3Cu2+: 1ENa and 1JNa; (ii) the external Cu2+-dependent internal Na concentration could be parsimoniously estimated, and (iii) the site-specific clam gill potentials could be monitored. Here we provided a new approach to monitor waterborne metal toxicity to reduce the nationwide economic losses due to bans on harvesting of contaminated clam and the potential risks to the health of clams. |
| first_indexed | 2024-04-11T13:18:49Z |
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| id | doaj.art-1a3a3925ade3411086d4659ca403cc53 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T13:18:49Z |
| publishDate | 2008-09-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-1a3a3925ade3411086d4659ca403cc532022-12-22T04:22:16ZengMDPI AGSensors1424-82202008-09-01895250526910.3390/s8095250Sodium Gill Potential as a Tool to Monitor Valve Closure Behavior in Freshwater Clam Corbicula fluminea in Response to CopperWei-Yu ChenLi-John JouChieh-Ming LinChung-Min LiaoValve closure behavior in freshwater clam Corbicula fluminea is a biologically sensitive endpoint. The purpose of this paper was to derive an electrophysiological response model of C. fluminea to assess copper (Cu)-sodium (Na) interactions in gill membrane, whereby valve closure behavior and Cu toxicity could be monitored. The proposed model was based on the integration of Cu bioavailability, Na and Cu internalizations, and electrochemically-based gill potentials. Based on Na active transport under non-equilibrium conditions, predicted gill potential of -8.2 mV agreed reasonably well with published the measured transepithelial potential of -7 mV in C. fluminea. Our proposed framework captured the general features observed in model applications including: (i) 50% inhibitory Cu2+ activities for Na membrane potential (ENa) and uptake rate (JNa) were estimated to be 0.072 and 0.043 mM, respectively, with a stoichiometry of 3Cu2+: 1ENa and 1JNa; (ii) the external Cu2+-dependent internal Na concentration could be parsimoniously estimated, and (iii) the site-specific clam gill potentials could be monitored. Here we provided a new approach to monitor waterborne metal toxicity to reduce the nationwide economic losses due to bans on harvesting of contaminated clam and the potential risks to the health of clams.http://www.mdpi.com/1424-8220/8/9/5250/ClamCorbicula flumineaBioavailabilityGill membrane potentialElectrophysiologyValve closure behavior |
| spellingShingle | Wei-Yu Chen Li-John Jou Chieh-Ming Lin Chung-Min Liao Sodium Gill Potential as a Tool to Monitor Valve Closure Behavior in Freshwater Clam Corbicula fluminea in Response to Copper Sensors Clam Corbicula fluminea Bioavailability Gill membrane potential Electrophysiology Valve closure behavior |
| title | Sodium Gill Potential as a Tool to Monitor Valve Closure Behavior in Freshwater Clam Corbicula fluminea in Response to Copper |
| title_full | Sodium Gill Potential as a Tool to Monitor Valve Closure Behavior in Freshwater Clam Corbicula fluminea in Response to Copper |
| title_fullStr | Sodium Gill Potential as a Tool to Monitor Valve Closure Behavior in Freshwater Clam Corbicula fluminea in Response to Copper |
| title_full_unstemmed | Sodium Gill Potential as a Tool to Monitor Valve Closure Behavior in Freshwater Clam Corbicula fluminea in Response to Copper |
| title_short | Sodium Gill Potential as a Tool to Monitor Valve Closure Behavior in Freshwater Clam Corbicula fluminea in Response to Copper |
| title_sort | sodium gill potential as a tool to monitor valve closure behavior in freshwater clam corbicula fluminea in response to copper |
| topic | Clam Corbicula fluminea Bioavailability Gill membrane potential Electrophysiology Valve closure behavior |
| url | http://www.mdpi.com/1424-8220/8/9/5250/ |
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