The Uncovered Function of the <i>Drosophila GBA1a</i>-Encoded Protein

The Uncovered Function of the <i>Drosophila GBA1a</i>-Encoded Protein

Human <i>GBA1</i> encodes lysosomal acid β-glucocerebrosidase (GCase), which hydrolyzes cleavage of the beta-glucosidic linkage of glucosylceramide (GlcCer). Mutations in this gene lead to reduced GCase activity, accumulation of glucosylceramide and glucosylsphingosine, and development o...

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Bibliographic Details
Main Authors: Or Cabasso, Sumit Paul, Gali Maor, Metsada Pasmanik-Chor, Wouter Kallemeijn, Johannes Aerts, Mia Horowitz
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
<i>GBA1</i>
acid β-glucocerebrosidase
Gaucher disease
unfolded protein response
inflammation
Online Access:https://www.mdpi.com/2073-4409/10/3/630

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