Association of right precuneus compression with apathy in idiopathic normal pressure hydrocephalus: a pilot study
Abstract Apathy is frequently observed in idiopathic normal pressure hydrocephalus (iNPH) and worsens cognitive impairment and gait disturbance. In this study, we evaluated the regions associated with apathy in iNPH using statistical imaging analysis on the whole brain, both in terms of cerebral blo...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23800-x |
| _version_ | 1811190451440451584 |
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| author | Yoshihiro Chadani Tetsuo Kashibayashi Takahiro Yamamoto Atsushi Tsuda Ryoko Fujito Masanori Akamatsu Naoto Kamimura Ryuichi Takahashi Takuji Yamagami Hirokazu Furuya Tetsuya Ueba Motoaki Saito Keiji Inoue Hiroaki Kazui |
| author_facet | Yoshihiro Chadani Tetsuo Kashibayashi Takahiro Yamamoto Atsushi Tsuda Ryoko Fujito Masanori Akamatsu Naoto Kamimura Ryuichi Takahashi Takuji Yamagami Hirokazu Furuya Tetsuya Ueba Motoaki Saito Keiji Inoue Hiroaki Kazui |
| author_sort | Yoshihiro Chadani |
| collection | DOAJ |
| description | Abstract Apathy is frequently observed in idiopathic normal pressure hydrocephalus (iNPH) and worsens cognitive impairment and gait disturbance. In this study, we evaluated the regions associated with apathy in iNPH using statistical imaging analysis on the whole brain, both in terms of cerebral blood flow and gray matter volume. Twenty-seven patients with iNPH were assigned to two groups based on their scores on the neuropsychiatric inventory items related to apathy; 18 patients were assigned to the group with apathy (iNPH + APA) and 9 to the group without apathy (iNPH − APA). The magnetic resonance images and cerebral blood flow single-photon emission computed tomography data of the two groups were compared using statistical parametric mapping 12. The regional gray matter volume of the right precuneus was significantly larger in the iNPH + APA group than in the iNPH − APA group, but the regional cerebral blood flow in any region of the brain was not significantly different between the two groups. These results suggested that the larger gray matter volume, which is thought to reflect gray matter compression, in the precuneus might be involved in apathy in iNPH. |
| first_indexed | 2024-04-11T14:51:23Z |
| format | Article |
| id | doaj.art-1a3ce94eed9e44ac99cc7d8c7174bc3a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T14:51:23Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1a3ce94eed9e44ac99cc7d8c7174bc3a2022-12-22T04:17:26ZengNature PortfolioScientific Reports2045-23222022-11-011211810.1038/s41598-022-23800-xAssociation of right precuneus compression with apathy in idiopathic normal pressure hydrocephalus: a pilot studyYoshihiro Chadani0Tetsuo Kashibayashi1Takahiro Yamamoto2Atsushi Tsuda3Ryoko Fujito4Masanori Akamatsu5Naoto Kamimura6Ryuichi Takahashi7Takuji Yamagami8Hirokazu Furuya9Tetsuya Ueba10Motoaki Saito11Keiji Inoue12Hiroaki Kazui13Department of Neuropsychiatry, Kochi Medical School, Kochi UniversityDepartment of Neuropsychiatry, Kochi Medical School, Kochi UniversityDepartment of Rehabilitation, Kochi Medical School, Kochi UniversityDepartment of Neuropsychiatry, Kochi Medical School, Kochi UniversityDepartment of Neuropsychiatry, Kochi Medical School, Kochi UniversityDepartment of Neuropsychiatry, Kochi Medical School, Kochi UniversityDepartment of Neuropsychiatry, Kochi Medical School, Kochi UniversityDementia-Related Disease Medical Center, Departments of Neurology and Cognitive Disorders, Hyogo Prefectural Rehabilitation Hospital at Nishi-HarimaDepartment of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi UniversityDepartment of Neurology, Kochi Medical School, Kochi UniversityDepartment of Neurosurgery, Kochi Medical School, Kochi UniversityDepartment of Pharmacology, Kochi Medical School, Kochi UniversityDepartment of Urology, Kochi Medical School, Kochi UniversityDepartment of Neuropsychiatry, Kochi Medical School, Kochi UniversityAbstract Apathy is frequently observed in idiopathic normal pressure hydrocephalus (iNPH) and worsens cognitive impairment and gait disturbance. In this study, we evaluated the regions associated with apathy in iNPH using statistical imaging analysis on the whole brain, both in terms of cerebral blood flow and gray matter volume. Twenty-seven patients with iNPH were assigned to two groups based on their scores on the neuropsychiatric inventory items related to apathy; 18 patients were assigned to the group with apathy (iNPH + APA) and 9 to the group without apathy (iNPH − APA). The magnetic resonance images and cerebral blood flow single-photon emission computed tomography data of the two groups were compared using statistical parametric mapping 12. The regional gray matter volume of the right precuneus was significantly larger in the iNPH + APA group than in the iNPH − APA group, but the regional cerebral blood flow in any region of the brain was not significantly different between the two groups. These results suggested that the larger gray matter volume, which is thought to reflect gray matter compression, in the precuneus might be involved in apathy in iNPH.https://doi.org/10.1038/s41598-022-23800-x |
| spellingShingle | Yoshihiro Chadani Tetsuo Kashibayashi Takahiro Yamamoto Atsushi Tsuda Ryoko Fujito Masanori Akamatsu Naoto Kamimura Ryuichi Takahashi Takuji Yamagami Hirokazu Furuya Tetsuya Ueba Motoaki Saito Keiji Inoue Hiroaki Kazui Association of right precuneus compression with apathy in idiopathic normal pressure hydrocephalus: a pilot study Scientific Reports |
| title | Association of right precuneus compression with apathy in idiopathic normal pressure hydrocephalus: a pilot study |
| title_full | Association of right precuneus compression with apathy in idiopathic normal pressure hydrocephalus: a pilot study |
| title_fullStr | Association of right precuneus compression with apathy in idiopathic normal pressure hydrocephalus: a pilot study |
| title_full_unstemmed | Association of right precuneus compression with apathy in idiopathic normal pressure hydrocephalus: a pilot study |
| title_short | Association of right precuneus compression with apathy in idiopathic normal pressure hydrocephalus: a pilot study |
| title_sort | association of right precuneus compression with apathy in idiopathic normal pressure hydrocephalus a pilot study |
| url | https://doi.org/10.1038/s41598-022-23800-x |
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