Neutrophil-to-lymphocyte ratio as a prognostic factor for patients with metastatic or recurrent breast cancer treated using capecitabine: a retrospective study
Abstract Background Eribulin or capecitabine monotherapy is the next cytotoxic chemotherapy option for patients with metastatic or recurrent breast cancer who have previously received an anthracycline or a taxane. However, it is unclear what factors can guide the selection of eribulin or capecitabin...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-01-01
|
| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-021-09112-9 |
| _version_ | 1818753524476936192 |
|---|---|
| author | Shigemasa Takamizawa Tatsunori Shimoi Natsuko Satomi-Tsushita Shu Yazaki Toshihiro Okuya Yuki Kojima Hitomi Sumiyoshi-Okuma Tadaaki Nishikawa Maki Tanioka Kazuki Sudo Emi Noguchi Kan Yonemori |
| author_facet | Shigemasa Takamizawa Tatsunori Shimoi Natsuko Satomi-Tsushita Shu Yazaki Toshihiro Okuya Yuki Kojima Hitomi Sumiyoshi-Okuma Tadaaki Nishikawa Maki Tanioka Kazuki Sudo Emi Noguchi Kan Yonemori |
| author_sort | Shigemasa Takamizawa |
| collection | DOAJ |
| description | Abstract Background Eribulin or capecitabine monotherapy is the next cytotoxic chemotherapy option for patients with metastatic or recurrent breast cancer who have previously received an anthracycline or a taxane. However, it is unclear what factors can guide the selection of eribulin or capecitabine in this setting, and prognostic factors are needed to guide appropriate treatment selection. The neutrophil-to-lymphocyte ratio (NLR) is a prognostic factor for eribulin-treated patients, although it is unclear whether it is a prognostic factor for capecitabine-treated patients. Therefore, we analysed the ability of the NLR to predict oncological outcomes among patients who received capecitabine after previous anthracycline or taxane treatment for breast cancer. Methods We retrospectively reviewed the medical records of patients with metastatic or recurrent breast cancer who had previously received anthracycline or taxane treatment at the National Cancer Center Hospital between 2007 and 2015. Patients were included if they received eribulin or capecitabine monotherapy as first-line, second-line, or third-line chemotherapy. Analyses of overall survival (OS) and progression-free survival (PFS) were performed according to various factors. Results Between 2007 and 2015, we identified 125 eligible patients, including 46 patients who received only eribulin, 34 patients who received only capecitabine, and 45 patients who received eribulin and capecitabine. The median follow-up period was 19.1 months. Among eribulin-treated patients, an NLR of <3 independently predicted better OS. Among capecitabine-treated patients, an NLR of <3 independently predicted better PFS but not better OS. In addition, a lymphocyte-to-monocyte ratio of ≥5 was associated with better PFS and OS. Conclusions To the best of our knowledge, this is the first study to evaluate whether the NLR is a prognostic factor for capecitabine-treated patients with metastatic or recurrent breast cancer. However, the NLR only independently predicted PFS in this setting, despite it being a useful prognostic factor for other chemotherapies. |
| first_indexed | 2024-12-18T05:08:44Z |
| format | Article |
| id | doaj.art-1a3d1d1d78eb446a83f9afbf76e57338 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-18T05:08:44Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-1a3d1d1d78eb446a83f9afbf76e573382022-12-21T21:19:57ZengBMCBMC Cancer1471-24072022-01-0122111010.1186/s12885-021-09112-9Neutrophil-to-lymphocyte ratio as a prognostic factor for patients with metastatic or recurrent breast cancer treated using capecitabine: a retrospective studyShigemasa Takamizawa0Tatsunori Shimoi1Natsuko Satomi-Tsushita2Shu Yazaki3Toshihiro Okuya4Yuki Kojima5Hitomi Sumiyoshi-Okuma6Tadaaki Nishikawa7Maki Tanioka8Kazuki Sudo9Emi Noguchi10Kan Yonemori11Department of Medical Oncology, National Cancer Center HospitalDepartment of Medical Oncology, National Cancer Center HospitalDepartment of Medical Oncology, National Cancer Center HospitalDepartment of Medical Oncology, National Cancer Center HospitalDepartment of Medical Oncology, National Cancer Center HospitalDepartment of Medical Oncology, National Cancer Center HospitalDepartment of Medical Oncology, National Cancer Center HospitalDepartment of Medical Oncology, National Cancer Center HospitalDepartment of Medical Oncology, National Cancer Center HospitalDepartment of Medical Oncology, National Cancer Center HospitalDepartment of Medical Oncology, National Cancer Center HospitalDepartment of Medical Oncology, National Cancer Center HospitalAbstract Background Eribulin or capecitabine monotherapy is the next cytotoxic chemotherapy option for patients with metastatic or recurrent breast cancer who have previously received an anthracycline or a taxane. However, it is unclear what factors can guide the selection of eribulin or capecitabine in this setting, and prognostic factors are needed to guide appropriate treatment selection. The neutrophil-to-lymphocyte ratio (NLR) is a prognostic factor for eribulin-treated patients, although it is unclear whether it is a prognostic factor for capecitabine-treated patients. Therefore, we analysed the ability of the NLR to predict oncological outcomes among patients who received capecitabine after previous anthracycline or taxane treatment for breast cancer. Methods We retrospectively reviewed the medical records of patients with metastatic or recurrent breast cancer who had previously received anthracycline or taxane treatment at the National Cancer Center Hospital between 2007 and 2015. Patients were included if they received eribulin or capecitabine monotherapy as first-line, second-line, or third-line chemotherapy. Analyses of overall survival (OS) and progression-free survival (PFS) were performed according to various factors. Results Between 2007 and 2015, we identified 125 eligible patients, including 46 patients who received only eribulin, 34 patients who received only capecitabine, and 45 patients who received eribulin and capecitabine. The median follow-up period was 19.1 months. Among eribulin-treated patients, an NLR of <3 independently predicted better OS. Among capecitabine-treated patients, an NLR of <3 independently predicted better PFS but not better OS. In addition, a lymphocyte-to-monocyte ratio of ≥5 was associated with better PFS and OS. Conclusions To the best of our knowledge, this is the first study to evaluate whether the NLR is a prognostic factor for capecitabine-treated patients with metastatic or recurrent breast cancer. However, the NLR only independently predicted PFS in this setting, despite it being a useful prognostic factor for other chemotherapies.https://doi.org/10.1186/s12885-021-09112-9Breast cancerCapecitabineChemotherapyEribulinNeutrophil-to-lymphocyte ratioNLR |
| spellingShingle | Shigemasa Takamizawa Tatsunori Shimoi Natsuko Satomi-Tsushita Shu Yazaki Toshihiro Okuya Yuki Kojima Hitomi Sumiyoshi-Okuma Tadaaki Nishikawa Maki Tanioka Kazuki Sudo Emi Noguchi Kan Yonemori Neutrophil-to-lymphocyte ratio as a prognostic factor for patients with metastatic or recurrent breast cancer treated using capecitabine: a retrospective study BMC Cancer Breast cancer Capecitabine Chemotherapy Eribulin Neutrophil-to-lymphocyte ratio NLR |
| title | Neutrophil-to-lymphocyte ratio as a prognostic factor for patients with metastatic or recurrent breast cancer treated using capecitabine: a retrospective study |
| title_full | Neutrophil-to-lymphocyte ratio as a prognostic factor for patients with metastatic or recurrent breast cancer treated using capecitabine: a retrospective study |
| title_fullStr | Neutrophil-to-lymphocyte ratio as a prognostic factor for patients with metastatic or recurrent breast cancer treated using capecitabine: a retrospective study |
| title_full_unstemmed | Neutrophil-to-lymphocyte ratio as a prognostic factor for patients with metastatic or recurrent breast cancer treated using capecitabine: a retrospective study |
| title_short | Neutrophil-to-lymphocyte ratio as a prognostic factor for patients with metastatic or recurrent breast cancer treated using capecitabine: a retrospective study |
| title_sort | neutrophil to lymphocyte ratio as a prognostic factor for patients with metastatic or recurrent breast cancer treated using capecitabine a retrospective study |
| topic | Breast cancer Capecitabine Chemotherapy Eribulin Neutrophil-to-lymphocyte ratio NLR |
| url | https://doi.org/10.1186/s12885-021-09112-9 |
| work_keys_str_mv | AT shigemasatakamizawa neutrophiltolymphocyteratioasaprognosticfactorforpatientswithmetastaticorrecurrentbreastcancertreatedusingcapecitabinearetrospectivestudy AT tatsunorishimoi neutrophiltolymphocyteratioasaprognosticfactorforpatientswithmetastaticorrecurrentbreastcancertreatedusingcapecitabinearetrospectivestudy AT natsukosatomitsushita neutrophiltolymphocyteratioasaprognosticfactorforpatientswithmetastaticorrecurrentbreastcancertreatedusingcapecitabinearetrospectivestudy AT shuyazaki neutrophiltolymphocyteratioasaprognosticfactorforpatientswithmetastaticorrecurrentbreastcancertreatedusingcapecitabinearetrospectivestudy AT toshihirookuya neutrophiltolymphocyteratioasaprognosticfactorforpatientswithmetastaticorrecurrentbreastcancertreatedusingcapecitabinearetrospectivestudy AT yukikojima neutrophiltolymphocyteratioasaprognosticfactorforpatientswithmetastaticorrecurrentbreastcancertreatedusingcapecitabinearetrospectivestudy AT hitomisumiyoshiokuma neutrophiltolymphocyteratioasaprognosticfactorforpatientswithmetastaticorrecurrentbreastcancertreatedusingcapecitabinearetrospectivestudy AT tadaakinishikawa neutrophiltolymphocyteratioasaprognosticfactorforpatientswithmetastaticorrecurrentbreastcancertreatedusingcapecitabinearetrospectivestudy AT makitanioka neutrophiltolymphocyteratioasaprognosticfactorforpatientswithmetastaticorrecurrentbreastcancertreatedusingcapecitabinearetrospectivestudy AT kazukisudo neutrophiltolymphocyteratioasaprognosticfactorforpatientswithmetastaticorrecurrentbreastcancertreatedusingcapecitabinearetrospectivestudy AT eminoguchi neutrophiltolymphocyteratioasaprognosticfactorforpatientswithmetastaticorrecurrentbreastcancertreatedusingcapecitabinearetrospectivestudy AT kanyonemori neutrophiltolymphocyteratioasaprognosticfactorforpatientswithmetastaticorrecurrentbreastcancertreatedusingcapecitabinearetrospectivestudy |