Systemic inflammation response index as a prognostic factor for patients with sepsis-associated acute kidney injury: a retrospective observational study
Objective To assess the association between the systemic inflammation response index (SIRI) and the prognosis in patients with sepsis-associated acute kidney injury (SA-AKI). Methods In this observational study, adult patients with SA-AKI were categorized into three groups based on SIRI tertiles. Su...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-03-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605241235758 |
| _version_ | 1797248190008786944 |
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| author | Jia Tang Zhenguang Zhong Muyesai Nijiati Changdong Wu |
| author_facet | Jia Tang Zhenguang Zhong Muyesai Nijiati Changdong Wu |
| author_sort | Jia Tang |
| collection | DOAJ |
| description | Objective To assess the association between the systemic inflammation response index (SIRI) and the prognosis in patients with sepsis-associated acute kidney injury (SA-AKI). Methods In this observational study, adult patients with SA-AKI were categorized into three groups based on SIRI tertiles. Survival outcomes were compared across the three groups using Kaplan–Meier survival curves. Various Cox proportional hazards regression models were developed to determine the association between the SIRI and mortality in patients with SA-AKI. Subgroup analyses were also performed to explore the association between different SIRI tertiles and all-cause mortality. Results After adjusting for several confounders, the second SIRI tertile (2.5 < SIRI < 7.6) was found to be an independent risk factor for 30-day mortality [hazard ratio (95% confidence interval): 1.19 (1.01–1.40)], 90-day mortality [1.22 (1.06–1.41)], and 365-day mortality [1.24 (1.09–1.40)]. Furthermore, high SIRI values were associated with increased risks of 30-day, 90-day, and 365-day mortality in patients with SA-AKI across all three models. The third tertile showed a significant association with adverse outcomes in most subgroups. Conclusions The SIRI serves as a comprehensive biomarker for predicting all-cause mortality of critically ill patients with SA-AKI. |
| first_indexed | 2024-04-24T20:10:39Z |
| format | Article |
| id | doaj.art-1a3d214e830648a8849c15af97f33ffd |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-04-24T20:10:39Z |
| publishDate | 2024-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-1a3d214e830648a8849c15af97f33ffd2024-03-23T10:03:57ZengSAGE PublishingJournal of International Medical Research1473-23002024-03-015210.1177/03000605241235758Systemic inflammation response index as a prognostic factor for patients with sepsis-associated acute kidney injury: a retrospective observational studyJia TangZhenguang ZhongMuyesai NijiatiChangdong WuObjective To assess the association between the systemic inflammation response index (SIRI) and the prognosis in patients with sepsis-associated acute kidney injury (SA-AKI). Methods In this observational study, adult patients with SA-AKI were categorized into three groups based on SIRI tertiles. Survival outcomes were compared across the three groups using Kaplan–Meier survival curves. Various Cox proportional hazards regression models were developed to determine the association between the SIRI and mortality in patients with SA-AKI. Subgroup analyses were also performed to explore the association between different SIRI tertiles and all-cause mortality. Results After adjusting for several confounders, the second SIRI tertile (2.5 < SIRI < 7.6) was found to be an independent risk factor for 30-day mortality [hazard ratio (95% confidence interval): 1.19 (1.01–1.40)], 90-day mortality [1.22 (1.06–1.41)], and 365-day mortality [1.24 (1.09–1.40)]. Furthermore, high SIRI values were associated with increased risks of 30-day, 90-day, and 365-day mortality in patients with SA-AKI across all three models. The third tertile showed a significant association with adverse outcomes in most subgroups. Conclusions The SIRI serves as a comprehensive biomarker for predicting all-cause mortality of critically ill patients with SA-AKI.https://doi.org/10.1177/03000605241235758 |
| spellingShingle | Jia Tang Zhenguang Zhong Muyesai Nijiati Changdong Wu Systemic inflammation response index as a prognostic factor for patients with sepsis-associated acute kidney injury: a retrospective observational study Journal of International Medical Research |
| title | Systemic inflammation response index as a prognostic factor for patients with sepsis-associated acute kidney injury: a retrospective observational study |
| title_full | Systemic inflammation response index as a prognostic factor for patients with sepsis-associated acute kidney injury: a retrospective observational study |
| title_fullStr | Systemic inflammation response index as a prognostic factor for patients with sepsis-associated acute kidney injury: a retrospective observational study |
| title_full_unstemmed | Systemic inflammation response index as a prognostic factor for patients with sepsis-associated acute kidney injury: a retrospective observational study |
| title_short | Systemic inflammation response index as a prognostic factor for patients with sepsis-associated acute kidney injury: a retrospective observational study |
| title_sort | systemic inflammation response index as a prognostic factor for patients with sepsis associated acute kidney injury a retrospective observational study |
| url | https://doi.org/10.1177/03000605241235758 |
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