Bispecific mAb<sup>2</sup> Antibodies Targeting CD59 Enhance the Complement-Dependent Cytotoxicity Mediated by Rituximab

Bispecific mAb<sup>2</sup> Antibodies Targeting CD59 Enhance the Complement-Dependent Cytotoxicity Mediated by Rituximab

Inhibition of complement activation via the overexpression of complement-regulatory proteins (CRPs), most notably CD46, CD55 and CD59, is an efficient mechanism of disguise of cancer cells from a host immune system. This phenomenon extends to counteract the potency of therapeutic antibodies that cou...

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Bibliographic Details
Main Authors:	Katharina Stadlbauer, Peter Andorfer, Gerhard Stadlmayr, Florian Rüker, Gordana Wozniak-Knopp
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Series:	International Journal of Molecular Sciences
Subjects:	bispecific antibody CD20 CD59 complement-dependent cytotoxicity complement regulatory protein Fcab
Online Access:	https://www.mdpi.com/1422-0067/23/9/5208

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