Three to Tango: MUC1 as a ligand for both E-selectin and ICAM-1 in the breast cancer metastatic cascade
Cancer cell tethering and rolling on the vascular wall is facilitated by various selectin:glycoprotein interactions which lead to eventual extravasation and metastases. The aberrantly underglycosylated mucin MUC1 has been shown to both abundantly express selectin binding moieties (sialyl Lewis x and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-07-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00076/full |