Citrus pectin based complexes for the tetracycline delivery
This research studied the formation of sodium polygalacturonate complexes with the antimicrobial drug ''Tetracycline''. The formation was confirmed by IR, UV and NMR spectroscopy. It was shown that the complexes were formed by electrostatic attraction and hydrogen bonding. The co...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Food Hydrocolloids for Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667025922000474 |
| _version_ | 1811190515064897536 |
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| author | Y.V. Chekunkov S.T. Minzanova A.V. Khabibullina D.M. Arkhipova L.G. Mironova A.D. Voloshina A.R. Khamatgalimov V.A. Milyukov |
| author_facet | Y.V. Chekunkov S.T. Minzanova A.V. Khabibullina D.M. Arkhipova L.G. Mironova A.D. Voloshina A.R. Khamatgalimov V.A. Milyukov |
| author_sort | Y.V. Chekunkov |
| collection | DOAJ |
| description | This research studied the formation of sodium polygalacturonate complexes with the antimicrobial drug ''Tetracycline''. The formation was confirmed by IR, UV and NMR spectroscopy. It was shown that the complexes were formed by electrostatic attraction and hydrogen bonding. The complexes demonstrated a high degree of drug binding to the polysaccharide matrix with the maximum content of tetracycline (6.68 wt %). The study of the antimicrobial activity of obtained compounds against S. aureus, B. cereus, E. coli showed no decrease in the antimicrobial effect compared to source tetracycline. Thus, the future research towards the new design compounds based on studied complexes could make contribution to a new generation of drugs based on pectin biopolymers. |
| first_indexed | 2024-04-11T14:51:24Z |
| format | Article |
| id | doaj.art-1a408af367314597adbdb928bbded76a |
| institution | Directory Open Access Journal |
| issn | 2667-0259 |
| language | English |
| last_indexed | 2024-04-11T14:51:24Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Hydrocolloids for Health |
| spelling | doaj.art-1a408af367314597adbdb928bbded76a2022-12-22T04:17:24ZengElsevierFood Hydrocolloids for Health2667-02592022-12-012100100Citrus pectin based complexes for the tetracycline deliveryY.V. Chekunkov0S.T. Minzanova1A.V. Khabibullina2D.M. Arkhipova3L.G. Mironova4A.D. Voloshina5A.R. Khamatgalimov6V.A. Milyukov7Corresponding author at: Arbuzov Institute of Organic and Physical Chemistry, Russian Academy of Sciences, FRC Kazan Scientific Center, Arbuzov Str. 8, 420088 Kazan, Russia.; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, RussiaThis research studied the formation of sodium polygalacturonate complexes with the antimicrobial drug ''Tetracycline''. The formation was confirmed by IR, UV and NMR spectroscopy. It was shown that the complexes were formed by electrostatic attraction and hydrogen bonding. The complexes demonstrated a high degree of drug binding to the polysaccharide matrix with the maximum content of tetracycline (6.68 wt %). The study of the antimicrobial activity of obtained compounds against S. aureus, B. cereus, E. coli showed no decrease in the antimicrobial effect compared to source tetracycline. Thus, the future research towards the new design compounds based on studied complexes could make contribution to a new generation of drugs based on pectin biopolymers.http://www.sciencedirect.com/science/article/pii/S2667025922000474PectinTetracyclineComplexationAntimicrobial activity |
| spellingShingle | Y.V. Chekunkov S.T. Minzanova A.V. Khabibullina D.M. Arkhipova L.G. Mironova A.D. Voloshina A.R. Khamatgalimov V.A. Milyukov Citrus pectin based complexes for the tetracycline delivery Food Hydrocolloids for Health Pectin Tetracycline Complexation Antimicrobial activity |
| title | Citrus pectin based complexes for the tetracycline delivery |
| title_full | Citrus pectin based complexes for the tetracycline delivery |
| title_fullStr | Citrus pectin based complexes for the tetracycline delivery |
| title_full_unstemmed | Citrus pectin based complexes for the tetracycline delivery |
| title_short | Citrus pectin based complexes for the tetracycline delivery |
| title_sort | citrus pectin based complexes for the tetracycline delivery |
| topic | Pectin Tetracycline Complexation Antimicrobial activity |
| url | http://www.sciencedirect.com/science/article/pii/S2667025922000474 |
| work_keys_str_mv | AT yvchekunkov citruspectinbasedcomplexesforthetetracyclinedelivery AT stminzanova citruspectinbasedcomplexesforthetetracyclinedelivery AT avkhabibullina citruspectinbasedcomplexesforthetetracyclinedelivery AT dmarkhipova citruspectinbasedcomplexesforthetetracyclinedelivery AT lgmironova citruspectinbasedcomplexesforthetetracyclinedelivery AT advoloshina citruspectinbasedcomplexesforthetetracyclinedelivery AT arkhamatgalimov citruspectinbasedcomplexesforthetetracyclinedelivery AT vamilyukov citruspectinbasedcomplexesforthetetracyclinedelivery |