Vitamin D Deficiency and Oral Health: A Comprehensive Review
Vitamin D (VD) levels have been gaining growing attention in Oral Health. During growth and adulthood, VD deficiency (VDD) is associated with a wide variety of oral health disorders, and impaired VD synthesis may expedite some of these conditions. In children, severe VDD can induce defective tooth m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/5/1471 |
| _version_ | 1797567542496067584 |
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| author | João Botelho Vanessa Machado Luís Proença Ana Sintra Delgado José João Mendes |
| author_facet | João Botelho Vanessa Machado Luís Proença Ana Sintra Delgado José João Mendes |
| author_sort | João Botelho |
| collection | DOAJ |
| description | Vitamin D (VD) levels have been gaining growing attention in Oral Health. During growth and adulthood, VD deficiency (VDD) is associated with a wide variety of oral health disorders, and impaired VD synthesis may expedite some of these conditions. In children, severe VDD can induce defective tooth mineralization, resulting in dentin and enamel defects. As a consequence, these defects may increase the risk of the onset and progression of dental caries. Further, VDD has been associated with higher prevalence of periodontitis and gingival inflammation, and several recent preclinical and clinical studies have unveiled potential pathways through which Vitamin D may interact with the periodontium. VDD correction through supplementation may contribute to a successful treatment of periodontitis; however, alveolar bone regeneration procedures performed in baseline VDD patients seem more prone to failure. Vitamin D may also be linked with some oral pathology entities such as certain oral cancers and events of osteonecrosis of the jaw. This review aims to provide comprehensive evidence of how VD levels should be considered to promote good oral health, and to summarize how VDD may hamper oral development and its role in certain oral conditions. |
| first_indexed | 2024-03-10T19:43:30Z |
| format | Article |
| id | doaj.art-1a42446f0d9040a88e6a5df1ec935855 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:43:30Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-1a42446f0d9040a88e6a5df1ec9358552023-11-20T00:57:30ZengMDPI AGNutrients2072-66432020-05-01125147110.3390/nu12051471Vitamin D Deficiency and Oral Health: A Comprehensive ReviewJoão Botelho0Vanessa Machado1Luís Proença2Ana Sintra Delgado3José João Mendes4Periodontology Department, Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Egas Moniz—Cooperativa de Ensino Superior, 2829-511 Caparica, Almada, PortugalPeriodontology Department, Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Egas Moniz—Cooperativa de Ensino Superior, 2829-511 Caparica, Almada, PortugalQuantitative Methods for Health Research Unit (MQIS), CiiEM, Egas Moniz—Cooperativa de Ensino Superior, 2829-511 Caparica, Almada, PortugalCRU, CiiEM, Egas Moniz—Cooperativa de Ensino Superior, 2829-511 Caparica, Almada, PortugalCRU, CiiEM, Egas Moniz—Cooperativa de Ensino Superior, 2829-511 Caparica, Almada, PortugalVitamin D (VD) levels have been gaining growing attention in Oral Health. During growth and adulthood, VD deficiency (VDD) is associated with a wide variety of oral health disorders, and impaired VD synthesis may expedite some of these conditions. In children, severe VDD can induce defective tooth mineralization, resulting in dentin and enamel defects. As a consequence, these defects may increase the risk of the onset and progression of dental caries. Further, VDD has been associated with higher prevalence of periodontitis and gingival inflammation, and several recent preclinical and clinical studies have unveiled potential pathways through which Vitamin D may interact with the periodontium. VDD correction through supplementation may contribute to a successful treatment of periodontitis; however, alveolar bone regeneration procedures performed in baseline VDD patients seem more prone to failure. Vitamin D may also be linked with some oral pathology entities such as certain oral cancers and events of osteonecrosis of the jaw. This review aims to provide comprehensive evidence of how VD levels should be considered to promote good oral health, and to summarize how VDD may hamper oral development and its role in certain oral conditions.https://www.mdpi.com/2072-6643/12/5/1471vitaminsvitamin D deficiencyoral healthperiodontal healthperiodontal diseaseperiodontitis |
| spellingShingle | João Botelho Vanessa Machado Luís Proença Ana Sintra Delgado José João Mendes Vitamin D Deficiency and Oral Health: A Comprehensive Review Nutrients vitamins vitamin D deficiency oral health periodontal health periodontal disease periodontitis |
| title | Vitamin D Deficiency and Oral Health: A Comprehensive Review |
| title_full | Vitamin D Deficiency and Oral Health: A Comprehensive Review |
| title_fullStr | Vitamin D Deficiency and Oral Health: A Comprehensive Review |
| title_full_unstemmed | Vitamin D Deficiency and Oral Health: A Comprehensive Review |
| title_short | Vitamin D Deficiency and Oral Health: A Comprehensive Review |
| title_sort | vitamin d deficiency and oral health a comprehensive review |
| topic | vitamins vitamin D deficiency oral health periodontal health periodontal disease periodontitis |
| url | https://www.mdpi.com/2072-6643/12/5/1471 |
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