Matrix metalloproteinase‐9 gene polymorphisms are associated with ischemic stroke severity and early neurologic deterioration in patients with atrial fibrillation
Abstract Objectives The mechanisms of ischemic stroke severity and early neurologic deterioration (END) are not fully understood. The aim of the present study was to investigate the association of six variants in MMP‐9 gene with ischemic stroke severity and the risk for END in ischemic stroke (IS) p...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-06-01
|
| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.1291 |
| _version_ | 1819153840116596736 |
|---|---|
| author | Xingyang Yi Qiang Zhou Guo Sui Daofeng Fan Yongyin Zhang Minjie Shao Zhao Han Hua Luo Jing Lin Ju Zhou |
| author_facet | Xingyang Yi Qiang Zhou Guo Sui Daofeng Fan Yongyin Zhang Minjie Shao Zhao Han Hua Luo Jing Lin Ju Zhou |
| author_sort | Xingyang Yi |
| collection | DOAJ |
| description | Abstract Objectives The mechanisms of ischemic stroke severity and early neurologic deterioration (END) are not fully understood. The aim of the present study was to investigate the association of six variants in MMP‐9 gene with ischemic stroke severity and the risk for END in ischemic stroke (IS) patients with atrial fibrillation (AF). Methods This was a multi‐center, prospective, observational study of 615 acute IS patients with AF admitted to six participating hospitals between June 2016 and October 2017. Ischemic stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) score on admission. END was defined as an increase of four or more points in NIHSS within 10 days of admission. Six variants of MMP‐9 gene were examined using mass spectrometry. Results Among the 615 enrolled patients, 112 (18.2%) patients presented with moderate or severe stroke (NIHSS score ≥16), and 108 (17.6%) patients suffered from END within 10 days of admission. Multiple logistic analysis showed that prestroke antiplatelet therapy, prestroke anticoagulant therapy, rs3918242 CT/TT, and rs3787268 AG/GG were independent predictors for stroke severity. Cox proportional hazard regression revealed that diabetes mellitus, prestroke antiplatelet therapy, prestroke anticoagulant therapy, rs1056628 AC/CC, and rs3918242 CT/TT were independently associated with the risk of END. Conclusions The incidence of moderate or severe stroke and END was very common in acute IS patients with AF. MMP‐9 polymorphisms were independently associated with severe stroke and higher risk of END, and prestroke antithrombotic treatment was associated with less severe stroke and lower risk of END in patients with AF. |
| first_indexed | 2024-12-22T15:11:34Z |
| format | Article |
| id | doaj.art-1a42f6cf7df64c31ae4bb441b3ed2c71 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-22T15:11:34Z |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-1a42f6cf7df64c31ae4bb441b3ed2c712022-12-21T18:21:51ZengWileyBrain and Behavior2162-32792019-06-0196n/an/a10.1002/brb3.1291Matrix metalloproteinase‐9 gene polymorphisms are associated with ischemic stroke severity and early neurologic deterioration in patients with atrial fibrillationXingyang Yi0Qiang Zhou1Guo Sui2Daofeng Fan3Yongyin Zhang4Minjie Shao5Zhao Han6Hua Luo7Jing Lin8Ju Zhou9Department of Neurology People’s Hospital of Deyang City Deyang ChinaDepartment of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaNursing Department The People’s Hospital of Deyang City Deyang ChinaDepartment of Neurology The Affiliated Longyan first Hospital of Fujian Medical University Longyan ChinaDepartment of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Neurology The Affiliated Wenling Hospital of Wenzhou Medical University Wenling ChinaDepartment of Neurology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Neurology The Affiliated Hospital of Southwest Medical University Luzhou ChinaDepartment of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Neurology People’s Hospital of Deyang City Deyang ChinaAbstract Objectives The mechanisms of ischemic stroke severity and early neurologic deterioration (END) are not fully understood. The aim of the present study was to investigate the association of six variants in MMP‐9 gene with ischemic stroke severity and the risk for END in ischemic stroke (IS) patients with atrial fibrillation (AF). Methods This was a multi‐center, prospective, observational study of 615 acute IS patients with AF admitted to six participating hospitals between June 2016 and October 2017. Ischemic stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) score on admission. END was defined as an increase of four or more points in NIHSS within 10 days of admission. Six variants of MMP‐9 gene were examined using mass spectrometry. Results Among the 615 enrolled patients, 112 (18.2%) patients presented with moderate or severe stroke (NIHSS score ≥16), and 108 (17.6%) patients suffered from END within 10 days of admission. Multiple logistic analysis showed that prestroke antiplatelet therapy, prestroke anticoagulant therapy, rs3918242 CT/TT, and rs3787268 AG/GG were independent predictors for stroke severity. Cox proportional hazard regression revealed that diabetes mellitus, prestroke antiplatelet therapy, prestroke anticoagulant therapy, rs1056628 AC/CC, and rs3918242 CT/TT were independently associated with the risk of END. Conclusions The incidence of moderate or severe stroke and END was very common in acute IS patients with AF. MMP‐9 polymorphisms were independently associated with severe stroke and higher risk of END, and prestroke antithrombotic treatment was associated with less severe stroke and lower risk of END in patients with AF.https://doi.org/10.1002/brb3.1291atrial fibrillationearly neurological deteriorationischemic strokeMMP‐9 variantsstroke severity |
| spellingShingle | Xingyang Yi Qiang Zhou Guo Sui Daofeng Fan Yongyin Zhang Minjie Shao Zhao Han Hua Luo Jing Lin Ju Zhou Matrix metalloproteinase‐9 gene polymorphisms are associated with ischemic stroke severity and early neurologic deterioration in patients with atrial fibrillation Brain and Behavior atrial fibrillation early neurological deterioration ischemic stroke MMP‐9 variants stroke severity |
| title | Matrix metalloproteinase‐9 gene polymorphisms are associated with ischemic stroke severity and early neurologic deterioration in patients with atrial fibrillation |
| title_full | Matrix metalloproteinase‐9 gene polymorphisms are associated with ischemic stroke severity and early neurologic deterioration in patients with atrial fibrillation |
| title_fullStr | Matrix metalloproteinase‐9 gene polymorphisms are associated with ischemic stroke severity and early neurologic deterioration in patients with atrial fibrillation |
| title_full_unstemmed | Matrix metalloproteinase‐9 gene polymorphisms are associated with ischemic stroke severity and early neurologic deterioration in patients with atrial fibrillation |
| title_short | Matrix metalloproteinase‐9 gene polymorphisms are associated with ischemic stroke severity and early neurologic deterioration in patients with atrial fibrillation |
| title_sort | matrix metalloproteinase 9 gene polymorphisms are associated with ischemic stroke severity and early neurologic deterioration in patients with atrial fibrillation |
| topic | atrial fibrillation early neurological deterioration ischemic stroke MMP‐9 variants stroke severity |
| url | https://doi.org/10.1002/brb3.1291 |
| work_keys_str_mv | AT xingyangyi matrixmetalloproteinase9genepolymorphismsareassociatedwithischemicstrokeseverityandearlyneurologicdeteriorationinpatientswithatrialfibrillation AT qiangzhou matrixmetalloproteinase9genepolymorphismsareassociatedwithischemicstrokeseverityandearlyneurologicdeteriorationinpatientswithatrialfibrillation AT guosui matrixmetalloproteinase9genepolymorphismsareassociatedwithischemicstrokeseverityandearlyneurologicdeteriorationinpatientswithatrialfibrillation AT daofengfan matrixmetalloproteinase9genepolymorphismsareassociatedwithischemicstrokeseverityandearlyneurologicdeteriorationinpatientswithatrialfibrillation AT yongyinzhang matrixmetalloproteinase9genepolymorphismsareassociatedwithischemicstrokeseverityandearlyneurologicdeteriorationinpatientswithatrialfibrillation AT minjieshao matrixmetalloproteinase9genepolymorphismsareassociatedwithischemicstrokeseverityandearlyneurologicdeteriorationinpatientswithatrialfibrillation AT zhaohan matrixmetalloproteinase9genepolymorphismsareassociatedwithischemicstrokeseverityandearlyneurologicdeteriorationinpatientswithatrialfibrillation AT hualuo matrixmetalloproteinase9genepolymorphismsareassociatedwithischemicstrokeseverityandearlyneurologicdeteriorationinpatientswithatrialfibrillation AT jinglin matrixmetalloproteinase9genepolymorphismsareassociatedwithischemicstrokeseverityandearlyneurologicdeteriorationinpatientswithatrialfibrillation AT juzhou matrixmetalloproteinase9genepolymorphismsareassociatedwithischemicstrokeseverityandearlyneurologicdeteriorationinpatientswithatrialfibrillation |