Radical Scavenging Activity and Pharmacokinetic Properties of Coumarin–Hydroxybenzohydrazide Hybrids

Radical Scavenging Activity and Pharmacokinetic Properties of Coumarin–Hydroxybenzohydrazide Hybrids

Free radicals often interact with vital proteins, violating their structure and inhibiting their activity. In previous studies, synthesis, characterisation, and the antioxidative properties of the five different coumarin derivatives have been investigated. In the tests of potential toxicity, all com...

Full description

Bibliographic Details
Main Authors:	Marko R. Antonijević, Edina H. Avdović, Dušica M. Simijonović, Žiko B. Milanović, Ana D. Amić, Zoran S. Marković
Format:	Article
Language:	English
Published:	MDPI AG 2022-01-01
Series:	International Journal of Molecular Sciences
Subjects:	radical scavenging antioxidants coumarins DFT pharmacokinetics
Online Access:	https://www.mdpi.com/1422-0067/23/1/490

Similar Items

Green One-Pot Synthesis of Coumarin-Hydroxybenzohydrazide Hybrids and Their Antioxidant Potency
by: Marko R. Antonijević, et al.
Published: (2021-07-01)

An Effective, Green Synthesis Procedure for Obtaining Coumarin–Hydroxybenzohydrazide Derivatives and Assessment of Their Antioxidant Activity and Redox Status
by: Edina H. Avdović, et al.
Published: (2023-12-01)

Coumarin <i>N</i>-Acylhydrazone Derivatives: Green Synthesis and Antioxidant Potential—Experimental and Theoretical Study
by: Dušica M. Simijonović, et al.
Published: (2023-10-01)

Mechanism of Antiradical Activity of Coumarin-Trihydroxybenzohydrazide Derivatives: A Comprehensive Kinetic DFT Study
by: Žiko Milanović, et al.
Published: (2024-01-01)

Mechanism of Antiradical Activity of Newly Synthesized 4,7-Dihydroxycoumarin Derivatives-Experimental and Kinetic DFT Study
by: Žiko Milanović, et al.
Published: (2021-12-01)

The Electronic Effects of 3-Methoxycarbonylcoumarin Substituents on Spectral, Antioxidant, and Protein Binding Properties
by: Jelena Vasić, et al.
Published: (2023-07-01)

Theoretical Study of Radical Inactivation, LOX Inhibition, and Iron Chelation: The Role of Ferulic Acid in Skin Protection against UVA Induced Oxidative Stress
by: Ana Amić, et al.
Published: (2021-08-01)

Coumarin-Palladium(II) Complex Acts as a Potent and Non-Toxic Anticancer Agent against Pancreatic Carcinoma Cells
by: Aleksandra Krstic, et al.
Published: (2022-03-01)

Synthesis and Cytotoxicity Evaluation of Novel Coumarin–Palladium(II) Complexes against Human Cancer Cell Lines
by: Edina H. Avdović, et al.
Published: (2022-12-01)

Synthesis, structural characterization, biological activity and molecular docking study of 4,7-dihydroxycoumarin modified by aminophenol derivatives
by: Milanović, Žiko B., et al.
Published: (2021-05-01)

Synthesis, Bio-evaluation and Quantum Chemical Studies of Some Coumarin Derivatives
by: Yasameen Al-Majedy, et al.
Published: (2021-12-01)

Radical-scavenging activities of marine-derived xyloketals and related chromanes
by: Zhongliang Xu, et al.
Published: (2013-09-01)

Pharmacokinetics of Novel Furoxan/Coumarin Hybrids in Rats Using LC-MS/MS Method and Physiologically Based Pharmacokinetic Model
by: Yawen Yuan, et al.
Published: (2023-01-01)

Pharmacokinetics and Tissue Distribution of Coumarins from <i>Tagetes lucida</i> in an LPS-Induced Neuroinflammation Model
by: Anislada Santibáñez, et al.
Published: (2022-10-01)

Synthesis and evaluation of antioxidant activity of some novel hydroxypyridinone derivatives: a DFT approach for explanation of their radical scavenging activity
by: Afshin Fassihi, et al.
Published: (2020-01-01)

<em>In Silico</em> design of hydroxylated coumarins and thermodynamic investigation of their free radical scavenging mechanism
by: I. O. Alisi, et al.
Published: (2020-12-01)

A New and Efficient Method for the Synthesis of Novel 3-Acetyl Coumarins Oxadiazoles Derivatives with Expected Biological Activity
by: Abdullah Sulaiman Al-Ayed, et al.
Published: (2014-01-01)

Molecular Modelling Based on TD-DFT Applied to UV Spectra of Coumarin Derivatives
by: Mokhamat Ariefin, et al.
Published: (2023-07-01)

Antioxidant Activity of Coumarins and Their Metal Complexes
by: Lozan Todorov, et al.
Published: (2023-04-01)

A Study on Hydrogen Peroxide Scavenging Activity and Ferric Reducing Ability of Simple Coumarins
by: N Prahadeesh, et al.
Published: (2018-12-01)

Synthesis, Crystallographic, Quantum Chemical, Antitumor, and Molecular Docking/Dynamic Studies of 4-Hydroxycoumarin-Neurotransmitter Derivatives
by: Dušan S. Dimić, et al.
Published: (2022-01-01)

Stability Study, Quantification Method and Pharmacokinetics Investigation of a Coumarin–Monoterpene Conjugate Possessing Antiviral Properties against Respiratory Syncytial Virus
by: Arina G. Nemolochnova, et al.
Published: (2022-09-01)

Theoretical and experimental evaluation of the anticorrosion properties of new Coumarin's derivatives
by: Manal M. Khowdiary, et al.
Published: (2022-09-01)

Coumarins in Food and Methods of Their Determination
by: Mirjana Lončar, et al.
Published: (2020-05-01)

Synthesis and Characterization of New Thiazolidinones Containing Coumarin Moieties and Their Antibacterial and Antioxidant Activities
by: Alary Fabienne, et al.
Published: (2012-08-01)

Antifungal Activities of New Coumarins
by: Ahmed A. Al-Amiery, et al.
Published: (2012-05-01)

Scaled quantum chemical studies of the structural and vibrational spectra of acetyl coumarin
by: Bahgat Khaled
Published: (2006-12-01)

Curcumin–Coumarin Hybrid Analogues as Multitarget Agents in Neurodegenerative Disorders
by: Elías Quezada, et al.
Published: (2021-07-01)

Optical property investigations of coumarin and indene diketone structure dyes: Experiment and calculation
by: Chao-jun Hua, et al.
Published: (2022-01-01)

DFT Calculations and Mesophase Study of Coumarin Esters and Its Azoesters
by: M. Hagar, et al.
Published: (2018-09-01)

Radical Scavenging Capability and Mechanism of Three Isoflavonoids Extracted from Radix Astragali: A Theoretical Study
by: Xiao-Qin Lu, et al.
Published: (2023-06-01)

Synthesis, characterization and biological investigations of potentially bioactive heterocyclic compounds containing 4-hydroxy coumarin
by: O. Nagaraja, et al.
Published: (2020-06-01)

2D-QSAR and docking study of a series of coumarin derivatives as inhibitors of CDK (anticancer activity) with an application of the molecular docking method
by: Rania Kasmi, et al.
Published: (2020-08-01)

Self-assembly of coumarin molecules on plasma electrolyzed layer for optimizing the electrochemical performance of AZ31 Mg alloy
by: Mosab Kaseem, et al.
Published: (2023-05-01)

Anthelmintic and anti-filarial coumarins of natural and synthetic origin: Chemical and biological intervention
by: Priyabrata Pattanayak, et al.
Published: (2024-01-01)

Discovery of Novel Coumarin-Schiff Base Hybrids as Potential Acetylcholinesterase Inhibitors: Design, Synthesis, Enzyme Inhibition, and Computational Studies
by: Aso Hameed Hasan, et al.
Published: (2023-07-01)

Novel Coumarin Derivatives with Expected Biological Activity
by: S. S. Abd El-Karim, et al.
Published: (2000-02-01)

Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties
by: Mohammad Bagher Majnooni, et al.
Published: (2020-04-01)

Synthesis, Characterization Of Various Coumarin Derivatives
by: Jamal M. Hamid
Published: (2013-06-01)

Pharmacokinetic Study of Anti-osteoarthritic Compounds of a Standardized Fraction from <i>Sphaeralcea Angustifolia</i>
by: Jade Serrano-Román, et al.
Published: (2021-06-01)