Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP.
BACKGROUND:To control and manipulate cellular signaling, we need to understand cellular strategies for information transfer, integration, and decision-making. A key feature of signal transduction is the generation of only a few intracellular messengers by many extracellular stimuli. METHODOLOGY/PRIN...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-10-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2760754?pdf=render |
| _version_ | 1819048384086933504 |
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| author | Fernando Siso-Nadal Jeffrey J Fox Stéphane A Laporte Terence E Hébert Peter S Swain |
| author_facet | Fernando Siso-Nadal Jeffrey J Fox Stéphane A Laporte Terence E Hébert Peter S Swain |
| author_sort | Fernando Siso-Nadal |
| collection | DOAJ |
| description | BACKGROUND:To control and manipulate cellular signaling, we need to understand cellular strategies for information transfer, integration, and decision-making. A key feature of signal transduction is the generation of only a few intracellular messengers by many extracellular stimuli. METHODOLOGY/PRINCIPAL FINDINGS:Here we model molecular cross-talk between two classic second messengers, cyclic AMP (cAMP) and calcium, and show that the dynamical complexity of the response of both messengers increases substantially through their interaction. In our model of a non-excitable cell, both cAMP and calcium concentrations can oscillate. If mutually inhibitory, cross-talk between the two second messengers can increase the range of agonist concentrations for which oscillations occur. If mutually activating, cross-talk decreases the oscillation range, but can generate 'bursting' oscillations of calcium and may enable better filtering of noise. CONCLUSION:We postulate that this increased dynamical complexity allows the cell to encode more information, particularly if both second messengers encode signals. In their native environments, it is unlikely that cells are exposed to one stimulus at a time, and cross-talk may help generate sufficiently complex responses to allow the cell to discriminate between different combinations and concentrations of extracellular agonists. |
| first_indexed | 2024-12-21T11:15:24Z |
| format | Article |
| id | doaj.art-1a441fe747314c639d6b10f916cc9231 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T11:15:24Z |
| publishDate | 2009-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1a441fe747314c639d6b10f916cc92312022-12-21T19:05:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-10-01410e718910.1371/journal.pone.0007189Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP.Fernando Siso-NadalJeffrey J FoxStéphane A LaporteTerence E HébertPeter S SwainBACKGROUND:To control and manipulate cellular signaling, we need to understand cellular strategies for information transfer, integration, and decision-making. A key feature of signal transduction is the generation of only a few intracellular messengers by many extracellular stimuli. METHODOLOGY/PRINCIPAL FINDINGS:Here we model molecular cross-talk between two classic second messengers, cyclic AMP (cAMP) and calcium, and show that the dynamical complexity of the response of both messengers increases substantially through their interaction. In our model of a non-excitable cell, both cAMP and calcium concentrations can oscillate. If mutually inhibitory, cross-talk between the two second messengers can increase the range of agonist concentrations for which oscillations occur. If mutually activating, cross-talk decreases the oscillation range, but can generate 'bursting' oscillations of calcium and may enable better filtering of noise. CONCLUSION:We postulate that this increased dynamical complexity allows the cell to encode more information, particularly if both second messengers encode signals. In their native environments, it is unlikely that cells are exposed to one stimulus at a time, and cross-talk may help generate sufficiently complex responses to allow the cell to discriminate between different combinations and concentrations of extracellular agonists.http://europepmc.org/articles/PMC2760754?pdf=render |
| spellingShingle | Fernando Siso-Nadal Jeffrey J Fox Stéphane A Laporte Terence E Hébert Peter S Swain Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP. PLoS ONE |
| title | Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP. |
| title_full | Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP. |
| title_fullStr | Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP. |
| title_full_unstemmed | Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP. |
| title_short | Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP. |
| title_sort | cross talk between signaling pathways can generate robust oscillations in calcium and camp |
| url | http://europepmc.org/articles/PMC2760754?pdf=render |
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