Amplifying mRNA vaccines: potential versatile magicians for oncotherapy
Cancer vaccines drive the activation and proliferation of tumor-reactive immune cells, thereby eliciting tumor-specific immunity that kills tumor cells. Accordingly, they possess immense potential in cancer treatment. However, such vaccines are also faced with challenges related to their design and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1261243/full |
| _version_ | 1797653258196484096 |
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| author | Chaoying Hu Chaoying Hu Chaoying Hu Jianyang Liu Jianyang Liu Jianyang Liu Feiran Cheng Feiran Cheng Feiran Cheng Yu Bai Yu Bai Yu Bai Qunying Mao Qunying Mao Qunying Mao Miao Xu Miao Xu Miao Xu Zhenglun Liang Zhenglun Liang Zhenglun Liang |
| author_facet | Chaoying Hu Chaoying Hu Chaoying Hu Jianyang Liu Jianyang Liu Jianyang Liu Feiran Cheng Feiran Cheng Feiran Cheng Yu Bai Yu Bai Yu Bai Qunying Mao Qunying Mao Qunying Mao Miao Xu Miao Xu Miao Xu Zhenglun Liang Zhenglun Liang Zhenglun Liang |
| author_sort | Chaoying Hu |
| collection | DOAJ |
| description | Cancer vaccines drive the activation and proliferation of tumor-reactive immune cells, thereby eliciting tumor-specific immunity that kills tumor cells. Accordingly, they possess immense potential in cancer treatment. However, such vaccines are also faced with challenges related to their design and considerable differences among individual tumors. The success of messenger RNA (mRNA) vaccines against coronavirus disease 2019 has prompted the application of mRNA vaccine technology platforms to the field of oncotherapy. These platforms include linear, circular, and amplifying mRNA vaccines. In particular, amplifying mRNA vaccines are characterized by high-level and prolonged antigen gene expression at low doses. They can also stimulate specific cellular immunity, making them highly promising in cancer vaccine research. In this review, we summarize the research progress in amplifying mRNA vaccines and provide an outlook of their prospects and future directions in oncotherapy. |
| first_indexed | 2024-03-11T16:41:57Z |
| format | Article |
| id | doaj.art-1a446582cd02435abf483c3f0135ce2d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T16:41:57Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1a446582cd02435abf483c3f0135ce2d2023-10-23T08:05:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-10-011410.3389/fimmu.2023.12612431261243Amplifying mRNA vaccines: potential versatile magicians for oncotherapyChaoying Hu0Chaoying Hu1Chaoying Hu2Jianyang Liu3Jianyang Liu4Jianyang Liu5Feiran Cheng6Feiran Cheng7Feiran Cheng8Yu Bai9Yu Bai10Yu Bai11Qunying Mao12Qunying Mao13Qunying Mao14Miao Xu15Miao Xu16Miao Xu17Zhenglun Liang18Zhenglun Liang19Zhenglun Liang20Division of Hepatitis and Enterovirus Vaccines, National Institutes for Food and Drug Control, Beijing, ChinaNational Health Commission (NHC), Key Laboratory of Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, Beijing, ChinaNational Medical Products Administration (NMPA), Key Laboratory for Quality Research and Evaluation of Biological Products, Institute of Biological Products, National Institutes for Food and Drug Control, Beijing, ChinaDivision of Hepatitis and Enterovirus Vaccines, National Institutes for Food and Drug Control, Beijing, ChinaNational Health Commission (NHC), Key Laboratory of Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, Beijing, ChinaNational Medical Products Administration (NMPA), Key Laboratory for Quality Research and Evaluation of Biological Products, Institute of Biological Products, National Institutes for Food and Drug Control, Beijing, ChinaDivision of Hepatitis and Enterovirus Vaccines, National Institutes for Food and Drug Control, Beijing, ChinaNational Health Commission (NHC), Key Laboratory of Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, Beijing, ChinaNational Medical Products Administration (NMPA), Key Laboratory for Quality Research and Evaluation of Biological Products, Institute of Biological Products, National Institutes for Food and Drug Control, Beijing, ChinaDivision of Hepatitis and Enterovirus Vaccines, National Institutes for Food and Drug Control, Beijing, ChinaNational Health Commission (NHC), Key Laboratory of Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, Beijing, ChinaNational Medical Products Administration (NMPA), Key Laboratory for Quality Research and Evaluation of Biological Products, Institute of Biological Products, National Institutes for Food and Drug Control, Beijing, ChinaDivision of Hepatitis and Enterovirus Vaccines, National Institutes for Food and Drug Control, Beijing, ChinaNational Health Commission (NHC), Key Laboratory of Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, Beijing, ChinaNational Medical Products Administration (NMPA), Key Laboratory for Quality Research and Evaluation of Biological Products, Institute of Biological Products, National Institutes for Food and Drug Control, Beijing, ChinaDivision of Hepatitis and Enterovirus Vaccines, National Institutes for Food and Drug Control, Beijing, ChinaNational Health Commission (NHC), Key Laboratory of Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, Beijing, ChinaNational Medical Products Administration (NMPA), Key Laboratory for Quality Research and Evaluation of Biological Products, Institute of Biological Products, National Institutes for Food and Drug Control, Beijing, ChinaDivision of Hepatitis and Enterovirus Vaccines, National Institutes for Food and Drug Control, Beijing, ChinaNational Health Commission (NHC), Key Laboratory of Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, Beijing, ChinaNational Medical Products Administration (NMPA), Key Laboratory for Quality Research and Evaluation of Biological Products, Institute of Biological Products, National Institutes for Food and Drug Control, Beijing, ChinaCancer vaccines drive the activation and proliferation of tumor-reactive immune cells, thereby eliciting tumor-specific immunity that kills tumor cells. Accordingly, they possess immense potential in cancer treatment. However, such vaccines are also faced with challenges related to their design and considerable differences among individual tumors. The success of messenger RNA (mRNA) vaccines against coronavirus disease 2019 has prompted the application of mRNA vaccine technology platforms to the field of oncotherapy. These platforms include linear, circular, and amplifying mRNA vaccines. In particular, amplifying mRNA vaccines are characterized by high-level and prolonged antigen gene expression at low doses. They can also stimulate specific cellular immunity, making them highly promising in cancer vaccine research. In this review, we summarize the research progress in amplifying mRNA vaccines and provide an outlook of their prospects and future directions in oncotherapy.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1261243/fullcancer vaccineamplifying mRNAtumor-specific antigentumor associated antigenin vitro transcription |
| spellingShingle | Chaoying Hu Chaoying Hu Chaoying Hu Jianyang Liu Jianyang Liu Jianyang Liu Feiran Cheng Feiran Cheng Feiran Cheng Yu Bai Yu Bai Yu Bai Qunying Mao Qunying Mao Qunying Mao Miao Xu Miao Xu Miao Xu Zhenglun Liang Zhenglun Liang Zhenglun Liang Amplifying mRNA vaccines: potential versatile magicians for oncotherapy Frontiers in Immunology cancer vaccine amplifying mRNA tumor-specific antigen tumor associated antigen in vitro transcription |
| title | Amplifying mRNA vaccines: potential versatile magicians for oncotherapy |
| title_full | Amplifying mRNA vaccines: potential versatile magicians for oncotherapy |
| title_fullStr | Amplifying mRNA vaccines: potential versatile magicians for oncotherapy |
| title_full_unstemmed | Amplifying mRNA vaccines: potential versatile magicians for oncotherapy |
| title_short | Amplifying mRNA vaccines: potential versatile magicians for oncotherapy |
| title_sort | amplifying mrna vaccines potential versatile magicians for oncotherapy |
| topic | cancer vaccine amplifying mRNA tumor-specific antigen tumor associated antigen in vitro transcription |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1261243/full |
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