Response of drug resistant isolates of Schistosoma mansoni to antischistosomal agents
The susceptibility of four isolates of Schistosoma mansoni (BH, MAP, MPR-1 and K) to four multiple doses of anti-schistosomal agents (hycanthone, niridazole, oxamniquire, and praziquantel) were evaluated in infected female Swiss albino mice. These schistosomal isolates had been maintained in the lab...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
1993-03-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000100014 |
| _version_ | 1797756689780310016 |
|---|---|
| author | Kristen M. Drescher Eugene J. Rogers John I. Bruce Naftale Katz Luiz Candido de Souza Dias Gerald C. Coles |
| author_facet | Kristen M. Drescher Eugene J. Rogers John I. Bruce Naftale Katz Luiz Candido de Souza Dias Gerald C. Coles |
| author_sort | Kristen M. Drescher |
| collection | DOAJ |
| description | The susceptibility of four isolates of Schistosoma mansoni (BH, MAP, MPR-1 and K) to four multiple doses of anti-schistosomal agents (hycanthone, niridazole, oxamniquire, and praziquantel) were evaluated in infected female Swiss albino mice. These schistosomal isolates had been maintained in the laboratory without further drug pressure for 20 to 30 generations. Multiple dosage regimens were used for each drug against each isolate of S. mansoni to generate ED50 (effective dose 50%) values. Results demonstrated that the K isolate is resistant to niridazole, the MPR-1 isolate to oxamniquine, and the MAP isolate to both hycanthone and oxamniquine. The BH isolate was susceptible to all drugs and was used as the reference isolate. All isolates were susceptible to praziquantel. The significance of the difference in response of the MPR-1 and MAP isolates is discussed. These results confirm the resistance of these isolates of S. mansoni of three schistosomicides and demonstrate that the resistance of these isolates are stable over long periods of time without exposure to drugs. |
| first_indexed | 2024-03-12T18:04:07Z |
| format | Article |
| id | doaj.art-1a458ddf733241a7b638a6adc69b2338 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:04:07Z |
| publishDate | 1993-03-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-1a458ddf733241a7b638a6adc69b23382023-08-02T09:29:08ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601993-03-01881899510.1590/S0074-02761993000100014Response of drug resistant isolates of Schistosoma mansoni to antischistosomal agentsKristen M. DrescherEugene J. RogersJohn I. BruceNaftale KatzLuiz Candido de Souza DiasGerald C. ColesThe susceptibility of four isolates of Schistosoma mansoni (BH, MAP, MPR-1 and K) to four multiple doses of anti-schistosomal agents (hycanthone, niridazole, oxamniquire, and praziquantel) were evaluated in infected female Swiss albino mice. These schistosomal isolates had been maintained in the laboratory without further drug pressure for 20 to 30 generations. Multiple dosage regimens were used for each drug against each isolate of S. mansoni to generate ED50 (effective dose 50%) values. Results demonstrated that the K isolate is resistant to niridazole, the MPR-1 isolate to oxamniquine, and the MAP isolate to both hycanthone and oxamniquine. The BH isolate was susceptible to all drugs and was used as the reference isolate. All isolates were susceptible to praziquantel. The significance of the difference in response of the MPR-1 and MAP isolates is discussed. These results confirm the resistance of these isolates of S. mansoni of three schistosomicides and demonstrate that the resistance of these isolates are stable over long periods of time without exposure to drugs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000100014Schistosoma mansonidrug-resistancepraziquantelhycanthoneoxamniquineniridazolesusceptibilityschistosome isolates (BH, MAP, K and MPR-1) |
| spellingShingle | Kristen M. Drescher Eugene J. Rogers John I. Bruce Naftale Katz Luiz Candido de Souza Dias Gerald C. Coles Response of drug resistant isolates of Schistosoma mansoni to antischistosomal agents Memorias do Instituto Oswaldo Cruz Schistosoma mansoni drug-resistance praziquantel hycanthone oxamniquine niridazole susceptibility schistosome isolates (BH, MAP, K and MPR-1) |
| title | Response of drug resistant isolates of Schistosoma mansoni to antischistosomal agents |
| title_full | Response of drug resistant isolates of Schistosoma mansoni to antischistosomal agents |
| title_fullStr | Response of drug resistant isolates of Schistosoma mansoni to antischistosomal agents |
| title_full_unstemmed | Response of drug resistant isolates of Schistosoma mansoni to antischistosomal agents |
| title_short | Response of drug resistant isolates of Schistosoma mansoni to antischistosomal agents |
| title_sort | response of drug resistant isolates of schistosoma mansoni to antischistosomal agents |
| topic | Schistosoma mansoni drug-resistance praziquantel hycanthone oxamniquine niridazole susceptibility schistosome isolates (BH, MAP, K and MPR-1) |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000100014 |
| work_keys_str_mv | AT kristenmdrescher responseofdrugresistantisolatesofschistosomamansonitoantischistosomalagents AT eugenejrogers responseofdrugresistantisolatesofschistosomamansonitoantischistosomalagents AT johnibruce responseofdrugresistantisolatesofschistosomamansonitoantischistosomalagents AT naftalekatz responseofdrugresistantisolatesofschistosomamansonitoantischistosomalagents AT luizcandidodesouzadias responseofdrugresistantisolatesofschistosomamansonitoantischistosomalagents AT geraldccoles responseofdrugresistantisolatesofschistosomamansonitoantischistosomalagents |