Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy
BACKGROUND: During the last few years it has been shown in several laboratories that Celecoxib (Cx), a non-steroidal anti-inflammatory agent (NSAID) normally used for pain and arthritis, mediates antitumor and antiangiogenic effects. However, the effects of this drug on a tumor cell line resistant t...
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| Format: | Article |
| Language: | English |
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BMC
2014-01-01
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| Series: | Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100027&lng=en&tlng=en |
| _version_ | 1819127180433555456 |
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| author | Carlos Rosas Mariana Sinning Arturo Ferreira Marcela Fuenzalida David Lemus |
| author_facet | Carlos Rosas Mariana Sinning Arturo Ferreira Marcela Fuenzalida David Lemus |
| author_sort | Carlos Rosas |
| collection | DOAJ |
| description | BACKGROUND: During the last few years it has been shown in several laboratories that Celecoxib (Cx), a non-steroidal anti-inflammatory agent (NSAID) normally used for pain and arthritis, mediates antitumor and antiangiogenic effects. However, the effects of this drug on a tumor cell line resistant to chemotherapeutical drugs used in cancer have not been described. Herein we evaluate the angiogenic and antitumor effects of Cx in the development of a drug-resistant mammary adenocarcinoma tumor (TA3-MTXR). RESULTS: Cx reduces angiogenesis in the chick embryonic chorioallantoic membrane assay (CAM), inhibits the growth and microvascular density of the murine TA3-MTXR tumor, reduces microvascular density of tumor metastases, promotes apoptosis and reduces vascular endothelial growth factor (VEGF) production and cell proliferation in the tumor. CONCLUSION: The antiangiogenic and antitumor Cx effects correlate with its activity on other tumor cell lines, suggesting that Prostaglandins (PGs) and VEGF production are involved. These results open the possibility of using Celecoxib combined with other experimental therapies, ideally aiming to get synergic effects. |
| first_indexed | 2024-12-22T08:07:50Z |
| format | Article |
| id | doaj.art-1a46e801a3344e92a0ab1958c68bcba7 |
| institution | Directory Open Access Journal |
| issn | 0716-9760 |
| language | English |
| last_indexed | 2024-12-22T08:07:50Z |
| publishDate | 2014-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Research |
| spelling | doaj.art-1a46e801a3344e92a0ab1958c68bcba72022-12-21T18:33:05ZengBMCBiological Research0716-97602014-01-014701910.1186/0717-6287-47-27S0716-97602014000100027Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapyCarlos Rosas0Mariana Sinning1Arturo Ferreira2Marcela Fuenzalida3David Lemus4Universidad de ChileUniversidad de ChileUniversidad de ChileUniversidad de ChileUniversidad de ChileBACKGROUND: During the last few years it has been shown in several laboratories that Celecoxib (Cx), a non-steroidal anti-inflammatory agent (NSAID) normally used for pain and arthritis, mediates antitumor and antiangiogenic effects. However, the effects of this drug on a tumor cell line resistant to chemotherapeutical drugs used in cancer have not been described. Herein we evaluate the angiogenic and antitumor effects of Cx in the development of a drug-resistant mammary adenocarcinoma tumor (TA3-MTXR). RESULTS: Cx reduces angiogenesis in the chick embryonic chorioallantoic membrane assay (CAM), inhibits the growth and microvascular density of the murine TA3-MTXR tumor, reduces microvascular density of tumor metastases, promotes apoptosis and reduces vascular endothelial growth factor (VEGF) production and cell proliferation in the tumor. CONCLUSION: The antiangiogenic and antitumor Cx effects correlate with its activity on other tumor cell lines, suggesting that Prostaglandins (PGs) and VEGF production are involved. These results open the possibility of using Celecoxib combined with other experimental therapies, ideally aiming to get synergic effects.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100027&lng=en&tlng=enAngiogenesisCelecoxibTumor |
| spellingShingle | Carlos Rosas Mariana Sinning Arturo Ferreira Marcela Fuenzalida David Lemus Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy Biological Research Angiogenesis Celecoxib Tumor |
| title | Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy |
| title_full | Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy |
| title_fullStr | Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy |
| title_full_unstemmed | Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy |
| title_short | Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy |
| title_sort | celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy |
| topic | Angiogenesis Celecoxib Tumor |
| url | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100027&lng=en&tlng=en |
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