Astragaloside IV attenuates sunitinib-associated cardiotoxicity by inhibiting COUP-TFII

Astragaloside IV attenuates sunitinib-associated cardiotoxicity by inhibiting COUP-TFII

Sunitinib (SU) is widely used to treat solid tumors but it can be cardiotoxic and often leads to drug withdrawn or discontinuation. Astragaloside IV (ASIV) is the essential active component of the Chinese herb Astragalus membranaceus which shows potential cardioprotective effects. Herein, we investi...

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Bibliographic Details
Main Authors: Wanting Qin, Shaoling Li, Ziji Cheng, Wenlong Xue, Mingyue Tian, Fangfang Mou, Haidong Guo, Shuijin Shao, Baonian Liu
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Heliyon
Subjects:
Astragaloside IV
Sunitinib-associated cardiotoxicity
COUP-TFII
Oxidative stress
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024008107

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