Cerebrospinal fluid penetration of tigecycline
Today very little is known about tigecycline penetration into cerebrospinal fluid (CSF). We report, in a clinical setting, tigecycline concentration, and the area under concentration-time curve (AUC) - both in blood and in CSF - of a patient affected by ventriculo-atrial shunt (VAS) infection due t...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1878 |
| _version_ | 1826911376717643776 |
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| author | Carlo Pallotto Maurizio Fiorio Antonio D'Avolio Alessio Sgrelli Franco Baldelli Giovanni Di Perri Giuseppe Vittorio Luigi De Socio |
| author_facet | Carlo Pallotto Maurizio Fiorio Antonio D'Avolio Alessio Sgrelli Franco Baldelli Giovanni Di Perri Giuseppe Vittorio Luigi De Socio |
| author_sort | Carlo Pallotto |
| collection | DOAJ |
| description | Today very little is known about tigecycline penetration into cerebrospinal fluid (CSF).
We report, in a clinical setting, tigecycline concentration, and the area under concentration-time curve (AUC) - both in blood and in CSF - of a patient affected by ventriculo-atrial shunt (VAS) infection due to Enterococcus faecium and Nocardia farcinica.
At the steady state, the serum and CSF concentration of tigecycline, at through, were 49 ng/mL and 5.2 ng/mL respectively, whereas the peak concentrations were 203 ng/mL and 13.4 ng /mL, with an average ratio of CSF-to-serum concentrations (CSF/serum) of 0.079. The serum AUC0-12 value was 1361.5 h*ng/ml, the CSF AUC0-12 was 91.6 h*ng/ml and the ratio between CSF and serum AUC0-12 (CSF/serum AUC0-12) was 0.067. Despite the low tigecycline CSF concentration, the microbiological tests were all negative. Tigecycline weakly penetrates CSF. |
| first_indexed | 2024-12-24T00:57:27Z |
| format | Article |
| id | doaj.art-1a4afdbe80cb4bde89110c66123533de |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2025-02-17T10:13:47Z |
| publishDate | 2014-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-1a4afdbe80cb4bde89110c66123533de2025-01-02T00:32:52ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-08-011Cerebrospinal fluid penetration of tigecyclineCarlo Pallotto0Maurizio Fiorio1Antonio D'Avolio2Alessio Sgrelli3Franco Baldelli4Giovanni Di Perri5Giuseppe Vittorio Luigi De Socio6Department of Infectious Diseases, “Santa Maria della Misericordia” Hospital, University of PerugiaDepartment of Infectious Diseases, “Santa Maria della Misericordia” Hospital, University of Perugia, Perugia, ItalyUnit of Infectious Diseases, University of Turin, Department of Medical Sciences, Amedeo di Savoia Hospital, Turin, ItalyDepartment of Infectious Diseases, “Santa Maria della Misericordia” Hospital, University of Perugia, Perugia, ItalyDepartment of Infectious Diseases, “Santa Maria della Misericordia” Hospital, University of Perugia, Perugia, ItalyUnit of Infectious Diseases, University of Turin, Department of Medical Sciences, Amedeo di Savoia Hospital, Turin, ItalyDepartment of Infectious Diseases, “Santa Maria della Misericordia” Hospital, University of Perugia, Perugia, ItalyToday very little is known about tigecycline penetration into cerebrospinal fluid (CSF). We report, in a clinical setting, tigecycline concentration, and the area under concentration-time curve (AUC) - both in blood and in CSF - of a patient affected by ventriculo-atrial shunt (VAS) infection due to Enterococcus faecium and Nocardia farcinica. At the steady state, the serum and CSF concentration of tigecycline, at through, were 49 ng/mL and 5.2 ng/mL respectively, whereas the peak concentrations were 203 ng/mL and 13.4 ng /mL, with an average ratio of CSF-to-serum concentrations (CSF/serum) of 0.079. The serum AUC0-12 value was 1361.5 h*ng/ml, the CSF AUC0-12 was 91.6 h*ng/ml and the ratio between CSF and serum AUC0-12 (CSF/serum AUC0-12) was 0.067. Despite the low tigecycline CSF concentration, the microbiological tests were all negative. Tigecycline weakly penetrates CSF.https://mjhid.org/index.php/mjhid/article/view/1878tigecyclineCSFpharmacokinetics |
| spellingShingle | Carlo Pallotto Maurizio Fiorio Antonio D'Avolio Alessio Sgrelli Franco Baldelli Giovanni Di Perri Giuseppe Vittorio Luigi De Socio Cerebrospinal fluid penetration of tigecycline Mediterranean Journal of Hematology and Infectious Diseases tigecycline CSF pharmacokinetics |
| title | Cerebrospinal fluid penetration of tigecycline |
| title_full | Cerebrospinal fluid penetration of tigecycline |
| title_fullStr | Cerebrospinal fluid penetration of tigecycline |
| title_full_unstemmed | Cerebrospinal fluid penetration of tigecycline |
| title_short | Cerebrospinal fluid penetration of tigecycline |
| title_sort | cerebrospinal fluid penetration of tigecycline |
| topic | tigecycline CSF pharmacokinetics |
| url | https://mjhid.org/index.php/mjhid/article/view/1878 |
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