Role of MRCP in Differentiation of Benign and Malignant Causes of Biliary Obstruction
Background: Differentiation of the benign and malignant etiology of biliary obstruction is difficult. We studied the diagnostic accuracy of MRCP (Magnetic Resonance Cholangiopancreatography) in differentiating between benign and malignant causes of biliary obstruction. Aim: To evaluate the role...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2015-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6771/14174_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1798043108521279488 |
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| author | Meena Suthar Sunita Purohit Vivek Bhargav Pradeep Goyal |
| author_facet | Meena Suthar Sunita Purohit Vivek Bhargav Pradeep Goyal |
| author_sort | Meena Suthar |
| collection | DOAJ |
| description | Background: Differentiation of the benign and malignant
etiology of biliary obstruction is difficult. We studied the
diagnostic accuracy of MRCP (Magnetic Resonance Cholangiopancreatography) in differentiating between benign and
malignant causes of biliary obstruction.
Aim: To evaluate the role of Magnetic Resonance CholangioPancreatography in differentiating benign from malignant causes
of biliary obstruction using surgical, ERCP or histopathological
findings as gold standard.
Materials and Methods: Seventy five patients with clinical and
laboratory finding suggestive of biliary obstruction underwent
MRI/MRCP. The final diagnosis was based on either surgical
findings, histopathology of resected specimen or ERCP findings.
Diagnostic effectivity of MRCP was calculated which included
sensitivity, specificity and accuracy. Statistical analysis was
done by using chi-square test and p value was calculated.
Results: Out of 75 cases, there were 54 benign and 21 malignant
cases. Mean age of patients with malignant obstruction
was more than benign with slight male preponderance. The
diagnostic accuracy of MRCP in differentiating benign from
malignant biliary obstructive diseases in correlation with
surgical, ERCP and histopathological outcome was 93.3%,
sensitivity 85.7%, specificity 96.3%. It was found that irregular,
asymmetric and long segment narrowing was more common in
malignant stricture.
Conclusions: MRCP is the investigation of choice for suspected
choledocholithiasis, choledochal cyst and primary sclerosing
cholangitis. A benign stricture can be differentiated from a
malignant one if it shows regular, symmetric and short segment
narrowing. Irregular, asymmetric and long segment narrowing
was more commonly found in malignant stricture. |
| first_indexed | 2024-04-11T22:45:00Z |
| format | Article |
| id | doaj.art-1a4bfef563f3460cb3cb98c2b281132b |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-11T22:45:00Z |
| publishDate | 2015-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-1a4bfef563f3460cb3cb98c2b281132b2022-12-22T03:58:48ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-11-01911TC08TC1210.7860/JCDR/2015/14174.6771Role of MRCP in Differentiation of Benign and Malignant Causes of Biliary ObstructionMeena Suthar0Sunita Purohit1Vivek Bhargav2Pradeep Goyal3Resident, Department of Radiodiagnosis, Santokba Durlabhji Memorial Hospital Cum Medical Research Institute, Jaipur, Rajasthan, India. Professor and Head, Department of Radiodiagnosis, Santokba Durlabhji Memorial Hospital Cum Medical Research Institute, Jaipur, Rajasthan, India.Consultant Radiologist, Okay Diagnostic Center, SDMH Jaipur, Rajasthan, India.Consultant Radiologist, Okay Diagnostic Center, SDMH Jaipur, Rajasthan, India.Background: Differentiation of the benign and malignant etiology of biliary obstruction is difficult. We studied the diagnostic accuracy of MRCP (Magnetic Resonance Cholangiopancreatography) in differentiating between benign and malignant causes of biliary obstruction. Aim: To evaluate the role of Magnetic Resonance CholangioPancreatography in differentiating benign from malignant causes of biliary obstruction using surgical, ERCP or histopathological findings as gold standard. Materials and Methods: Seventy five patients with clinical and laboratory finding suggestive of biliary obstruction underwent MRI/MRCP. The final diagnosis was based on either surgical findings, histopathology of resected specimen or ERCP findings. Diagnostic effectivity of MRCP was calculated which included sensitivity, specificity and accuracy. Statistical analysis was done by using chi-square test and p value was calculated. Results: Out of 75 cases, there were 54 benign and 21 malignant cases. Mean age of patients with malignant obstruction was more than benign with slight male preponderance. The diagnostic accuracy of MRCP in differentiating benign from malignant biliary obstructive diseases in correlation with surgical, ERCP and histopathological outcome was 93.3%, sensitivity 85.7%, specificity 96.3%. It was found that irregular, asymmetric and long segment narrowing was more common in malignant stricture. Conclusions: MRCP is the investigation of choice for suspected choledocholithiasis, choledochal cyst and primary sclerosing cholangitis. A benign stricture can be differentiated from a malignant one if it shows regular, symmetric and short segment narrowing. Irregular, asymmetric and long segment narrowing was more commonly found in malignant stricture.https://jcdr.net/articles/PDF/6771/14174_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdfbiliary obstructioncholangiocarcinomacholedocholithiasis |
| spellingShingle | Meena Suthar Sunita Purohit Vivek Bhargav Pradeep Goyal Role of MRCP in Differentiation of Benign and Malignant Causes of Biliary Obstruction Journal of Clinical and Diagnostic Research biliary obstruction cholangiocarcinoma choledocholithiasis |
| title | Role of MRCP in Differentiation of Benign and Malignant Causes of Biliary Obstruction |
| title_full | Role of MRCP in Differentiation of Benign and Malignant Causes of Biliary Obstruction |
| title_fullStr | Role of MRCP in Differentiation of Benign and Malignant Causes of Biliary Obstruction |
| title_full_unstemmed | Role of MRCP in Differentiation of Benign and Malignant Causes of Biliary Obstruction |
| title_short | Role of MRCP in Differentiation of Benign and Malignant Causes of Biliary Obstruction |
| title_sort | role of mrcp in differentiation of benign and malignant causes of biliary obstruction |
| topic | biliary obstruction cholangiocarcinoma choledocholithiasis |
| url | https://jcdr.net/articles/PDF/6771/14174_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
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