Association of vitamin D deficiency and subclinical diabetic peripheral neuropathy in type 2 diabetes patients
BackgroundDiabetic peripheral neuropathy (DPN) contributes to disability and imposes heavy burdens, while subclinical DPN is lack of attention so far. We aimed to investigate the relationship between vitamin D and distinct subtypes of subclinical DPN in type 2 diabetes (T2DM) patients.MethodsThis cr...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1354511/full |
| _version_ | 1797246705141284864 |
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| author | Xiaoyang Sun Xiaoyang Sun Xinyu Yang Xinyu Yang Xiaopeng Zhu Xiaopeng Zhu Yu Ma Xu Li Yuying Zhang Yuying Zhang Qiling Liu Qiling Liu Chenmin Fan Chenmin Fan Miao Zhang Miao Zhang Binger Xu Binger Xu Yanlan Xu Yanlan Xu Yanlan Xu Xin Gao Xin Gao Jihong Dong Mingfeng Xia Mingfeng Xia Hua Bian Hua Bian |
| author_facet | Xiaoyang Sun Xiaoyang Sun Xinyu Yang Xinyu Yang Xiaopeng Zhu Xiaopeng Zhu Yu Ma Xu Li Yuying Zhang Yuying Zhang Qiling Liu Qiling Liu Chenmin Fan Chenmin Fan Miao Zhang Miao Zhang Binger Xu Binger Xu Yanlan Xu Yanlan Xu Yanlan Xu Xin Gao Xin Gao Jihong Dong Mingfeng Xia Mingfeng Xia Hua Bian Hua Bian |
| author_sort | Xiaoyang Sun |
| collection | DOAJ |
| description | BackgroundDiabetic peripheral neuropathy (DPN) contributes to disability and imposes heavy burdens, while subclinical DPN is lack of attention so far. We aimed to investigate the relationship between vitamin D and distinct subtypes of subclinical DPN in type 2 diabetes (T2DM) patients.MethodsThis cross-sectional study included 3629 T2DM inpatients who undertook nerve conduction study to detect subclinical DPN in Zhongshan Hospital between March 2012 and December 2019. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D (25(OH)D) level < 50 nmol/L.Results1620 (44.6%) patients had subclinical DPN and they were further divided into subgroups: distal symmetric polyneuropathy (DSPN) (n=685), mononeuropathy (n=679) and radiculopathy (n=256). Compared with non-DPN, DPN group had significantly lower level of 25(OH)D (P < 0.05). In DPN subtypes, only DSPN patients had significantly lower levels of 25(OH)D (36.18 ± 19.47 vs. 41.03 ± 18.47 nmol/L, P < 0.001) and higher proportion of vitamin D deficiency (78.54% vs. 72.18%, P < 0.001) than non-DPN. Vitamin D deficiency was associated with the increased prevalence of subclinical DPN [odds ratio (OR) 1.276, 95% confidence interval (CI) 1.086-1.501, P = 0.003] and DSPN [OR 1. 646, 95% CI 1.31-2.078, P < 0.001], independent of sex, age, weight, blood pressure, glycosylated hemoglobin, T2DM duration, calcium, phosphorus, parathyroid hormone, lipids and renal function. The association between vitamin D deficiency and mononeuropathy or radiculopathy was not statistically significant. A negative linear association was observed between 25(OH)D and subclinical DSPN. Vitamin D deficiency maintained its significant association with subclinical DSPN in all age groups.ConclusionsVitamin D deficiency was independently associated with subclinical DSPN, rather than other DPN subtypes. |
| first_indexed | 2024-04-24T19:47:02Z |
| format | Article |
| id | doaj.art-1a4ee519720a49818c2683348788d71d |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T19:47:02Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-1a4ee519720a49818c2683348788d71d2024-03-25T04:24:40ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.13545111354511Association of vitamin D deficiency and subclinical diabetic peripheral neuropathy in type 2 diabetes patientsXiaoyang Sun0Xiaoyang Sun1Xinyu Yang2Xinyu Yang3Xiaopeng Zhu4Xiaopeng Zhu5Yu Ma6Xu Li7Yuying Zhang8Yuying Zhang9Qiling Liu10Qiling Liu11Chenmin Fan12Chenmin Fan13Miao Zhang14Miao Zhang15Binger Xu16Binger Xu17Yanlan Xu18Yanlan Xu19Yanlan Xu20Xin Gao21Xin Gao22Jihong Dong23Mingfeng Xia24Mingfeng Xia25Hua Bian26Hua Bian27Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, ChinaInstitute of Metabolic Disease, Fudan University, Shanghai, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, ChinaInstitute of Metabolic Disease, Fudan University, Shanghai, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, ChinaInstitute of Metabolic Disease, Fudan University, Shanghai, ChinaDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai, ChinaInstitute of Metabolism &Integrative Biology (IMIB), Fudan University, Shanghai, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, ChinaInstitute of Metabolic Disease, Fudan University, Shanghai, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, ChinaInstitute of Metabolic Disease, Fudan University, Shanghai, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, ChinaInstitute of Metabolic Disease, Fudan University, Shanghai, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, ChinaInstitute of Metabolic Disease, Fudan University, Shanghai, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, ChinaInstitute of Metabolic Disease, Fudan University, Shanghai, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, ChinaInstitute of Metabolic Disease, Fudan University, Shanghai, ChinaDepartment of Geriatrics, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, ChinaInstitute of Metabolic Disease, Fudan University, Shanghai, ChinaDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, ChinaInstitute of Metabolic Disease, Fudan University, Shanghai, ChinaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, ChinaInstitute of Metabolic Disease, Fudan University, Shanghai, ChinaBackgroundDiabetic peripheral neuropathy (DPN) contributes to disability and imposes heavy burdens, while subclinical DPN is lack of attention so far. We aimed to investigate the relationship between vitamin D and distinct subtypes of subclinical DPN in type 2 diabetes (T2DM) patients.MethodsThis cross-sectional study included 3629 T2DM inpatients who undertook nerve conduction study to detect subclinical DPN in Zhongshan Hospital between March 2012 and December 2019. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D (25(OH)D) level < 50 nmol/L.Results1620 (44.6%) patients had subclinical DPN and they were further divided into subgroups: distal symmetric polyneuropathy (DSPN) (n=685), mononeuropathy (n=679) and radiculopathy (n=256). Compared with non-DPN, DPN group had significantly lower level of 25(OH)D (P < 0.05). In DPN subtypes, only DSPN patients had significantly lower levels of 25(OH)D (36.18 ± 19.47 vs. 41.03 ± 18.47 nmol/L, P < 0.001) and higher proportion of vitamin D deficiency (78.54% vs. 72.18%, P < 0.001) than non-DPN. Vitamin D deficiency was associated with the increased prevalence of subclinical DPN [odds ratio (OR) 1.276, 95% confidence interval (CI) 1.086-1.501, P = 0.003] and DSPN [OR 1. 646, 95% CI 1.31-2.078, P < 0.001], independent of sex, age, weight, blood pressure, glycosylated hemoglobin, T2DM duration, calcium, phosphorus, parathyroid hormone, lipids and renal function. The association between vitamin D deficiency and mononeuropathy or radiculopathy was not statistically significant. A negative linear association was observed between 25(OH)D and subclinical DSPN. Vitamin D deficiency maintained its significant association with subclinical DSPN in all age groups.ConclusionsVitamin D deficiency was independently associated with subclinical DSPN, rather than other DPN subtypes.https://www.frontiersin.org/articles/10.3389/fendo.2024.1354511/fullvitamin Ddiabetic peripheral neuropathydistal symmetric polyneuropathytype 2 diabetesnerve conduction study (NCS) |
| spellingShingle | Xiaoyang Sun Xiaoyang Sun Xinyu Yang Xinyu Yang Xiaopeng Zhu Xiaopeng Zhu Yu Ma Xu Li Yuying Zhang Yuying Zhang Qiling Liu Qiling Liu Chenmin Fan Chenmin Fan Miao Zhang Miao Zhang Binger Xu Binger Xu Yanlan Xu Yanlan Xu Yanlan Xu Xin Gao Xin Gao Jihong Dong Mingfeng Xia Mingfeng Xia Hua Bian Hua Bian Association of vitamin D deficiency and subclinical diabetic peripheral neuropathy in type 2 diabetes patients Frontiers in Endocrinology vitamin D diabetic peripheral neuropathy distal symmetric polyneuropathy type 2 diabetes nerve conduction study (NCS) |
| title | Association of vitamin D deficiency and subclinical diabetic peripheral neuropathy in type 2 diabetes patients |
| title_full | Association of vitamin D deficiency and subclinical diabetic peripheral neuropathy in type 2 diabetes patients |
| title_fullStr | Association of vitamin D deficiency and subclinical diabetic peripheral neuropathy in type 2 diabetes patients |
| title_full_unstemmed | Association of vitamin D deficiency and subclinical diabetic peripheral neuropathy in type 2 diabetes patients |
| title_short | Association of vitamin D deficiency and subclinical diabetic peripheral neuropathy in type 2 diabetes patients |
| title_sort | association of vitamin d deficiency and subclinical diabetic peripheral neuropathy in type 2 diabetes patients |
| topic | vitamin D diabetic peripheral neuropathy distal symmetric polyneuropathy type 2 diabetes nerve conduction study (NCS) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1354511/full |
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