Protocol for efficient dearomatization of N-heteroaromatics with halogen(I) complex catalyst
Summary: In this protocol, we describe the application of a halogen(I) complex as a highly active non-metallic complex catalyst. Specifically, we present a detailed guide to synthesize the halogen(I) complex catalyst and utilize it as an anion-binding catalyst for the Mukaiyama-Mannich-type reaction...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
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| Series: | STAR Protocols |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666166723000989 |
| _version_ | 1827994081640316928 |
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| author | Shunya Oishi Takeshi Fujinami Yu Masui Toshiyasu Suzuki Masayuki Kato Naoya Ohtsuka Norie Momiyama |
| author_facet | Shunya Oishi Takeshi Fujinami Yu Masui Toshiyasu Suzuki Masayuki Kato Naoya Ohtsuka Norie Momiyama |
| author_sort | Shunya Oishi |
| collection | DOAJ |
| description | Summary: In this protocol, we describe the application of a halogen(I) complex as a highly active non-metallic complex catalyst. Specifically, we present a detailed guide to synthesize the halogen(I) complex catalyst and utilize it as an anion-binding catalyst for the Mukaiyama-Mannich-type reaction of N-heteroaromatics such as pyridines. By utilizing a simple catalyst preparation approach and relatively low catalyst loading, the steps outlined in this protocol contribute to the rapid development of useful substances such as pharmaceuticals and functional materials.For complete details on the use and execution of this protocol, please refer to Oishi et al. (2022).1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics. |
| first_indexed | 2024-04-10T04:34:41Z |
| format | Article |
| id | doaj.art-1a4fa46351314457834f75873fc79c78 |
| institution | Directory Open Access Journal |
| issn | 2666-1667 |
| language | English |
| last_indexed | 2024-04-10T04:34:41Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | STAR Protocols |
| spelling | doaj.art-1a4fa46351314457834f75873fc79c782023-03-10T04:36:10ZengElsevierSTAR Protocols2666-16672023-03-0141102140Protocol for efficient dearomatization of N-heteroaromatics with halogen(I) complex catalystShunya Oishi0Takeshi Fujinami1Yu Masui2Toshiyasu Suzuki3Masayuki Kato4Naoya Ohtsuka5Norie Momiyama6Institute for Molecular Science, Okazaki, Aichi 444-8787, Japan; SOKENDAI (The Graduate University for Advanced Studies), Okazaki, Aichi 444-8787, JapanInstitute for Molecular Science, Okazaki, Aichi 444-8787, JapanInstitute for Molecular Science, Okazaki, Aichi 444-8787, Japan; SOKENDAI (The Graduate University for Advanced Studies), Okazaki, Aichi 444-8787, JapanInstitute for Molecular Science, Okazaki, Aichi 444-8787, JapanInstitute for Molecular Science, Okazaki, Aichi 444-8787, Japan; SOKENDAI (The Graduate University for Advanced Studies), Okazaki, Aichi 444-8787, JapanInstitute for Molecular Science, Okazaki, Aichi 444-8787, Japan; SOKENDAI (The Graduate University for Advanced Studies), Okazaki, Aichi 444-8787, JapanInstitute for Molecular Science, Okazaki, Aichi 444-8787, Japan; SOKENDAI (The Graduate University for Advanced Studies), Okazaki, Aichi 444-8787, Japan; Corresponding authorSummary: In this protocol, we describe the application of a halogen(I) complex as a highly active non-metallic complex catalyst. Specifically, we present a detailed guide to synthesize the halogen(I) complex catalyst and utilize it as an anion-binding catalyst for the Mukaiyama-Mannich-type reaction of N-heteroaromatics such as pyridines. By utilizing a simple catalyst preparation approach and relatively low catalyst loading, the steps outlined in this protocol contribute to the rapid development of useful substances such as pharmaceuticals and functional materials.For complete details on the use and execution of this protocol, please refer to Oishi et al. (2022).1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.http://www.sciencedirect.com/science/article/pii/S2666166723000989ChemistryEnvironmental sciences |
| spellingShingle | Shunya Oishi Takeshi Fujinami Yu Masui Toshiyasu Suzuki Masayuki Kato Naoya Ohtsuka Norie Momiyama Protocol for efficient dearomatization of N-heteroaromatics with halogen(I) complex catalyst STAR Protocols Chemistry Environmental sciences |
| title | Protocol for efficient dearomatization of N-heteroaromatics with halogen(I) complex catalyst |
| title_full | Protocol for efficient dearomatization of N-heteroaromatics with halogen(I) complex catalyst |
| title_fullStr | Protocol for efficient dearomatization of N-heteroaromatics with halogen(I) complex catalyst |
| title_full_unstemmed | Protocol for efficient dearomatization of N-heteroaromatics with halogen(I) complex catalyst |
| title_short | Protocol for efficient dearomatization of N-heteroaromatics with halogen(I) complex catalyst |
| title_sort | protocol for efficient dearomatization of n heteroaromatics with halogen i complex catalyst |
| topic | Chemistry Environmental sciences |
| url | http://www.sciencedirect.com/science/article/pii/S2666166723000989 |
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