In vitro and in vivo study on fine-grained Mg–Zn–RE–Zr alloy as a biodegradeable orthopedic implant produced by friction stir processing
Magnesium alloys containing biocompatible components show tremendous promise for applications as temporary biomedical devices. However, to ensure their safe use as biodegradeable implants, it is essential to control their corrosion rates. In concentrated Mg alloys, a microgalvanic coupling between t...
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KeAi Communications Co., Ltd.
2023-10-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X23001913 |
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| author | Vasanth C. Shunmugasamy Marwa AbdelGawad Muhammad Umar Sohail Talal Ibrahim Talha Khan Thomas Daniel Seers Bilal Mansoor |
| author_facet | Vasanth C. Shunmugasamy Marwa AbdelGawad Muhammad Umar Sohail Talal Ibrahim Talha Khan Thomas Daniel Seers Bilal Mansoor |
| author_sort | Vasanth C. Shunmugasamy |
| collection | DOAJ |
| description | Magnesium alloys containing biocompatible components show tremendous promise for applications as temporary biomedical devices. However, to ensure their safe use as biodegradeable implants, it is essential to control their corrosion rates. In concentrated Mg alloys, a microgalvanic coupling between the α-Mg matrix and secondary precipitates exists which results in increased corrosion rate. To address this challenge, we engineered the microstructure of a biodegradable Mg–Zn–RE–Zr alloy by friction stir processing (FSP), improving its corrosion resistance and mechanical properties simultaneously. The FS processed alloy with refined grains and broken and uniformly distributed secondary precipitates showed a relatively uniform corrosion morphology accompanied with the formation of a stable passive layer on the alloy surface. In vivo corrosion evaluation of the processed alloy in a small animal model showed that the material was well-tolerated with no signs of inflammation or harmful by-products. Remarkably, the processed alloy supported bone until it healed till eight weeks with a low in vivo corrosion rate of 0.7 mm/year. Moreover, we analyzed blood and histology of the critical organs such as liver and kidney, which showed normal functionality and consistent ion and enzyme levels, throughout the 12-week study period. These results demonstrate that the processed Mg–Zn–RE–Zr alloy offers promising potential for osseointegration in bone tissue healing while also exhibiting controlled biodegradability due to its engineered microstructure. The results from the present study will have profound benefit for bone fracture management, particularly in pediatric and elderly patients. |
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| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:26:36Z |
| publishDate | 2023-10-01 |
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| series | Bioactive Materials |
| spelling | doaj.art-1a512094d33a495ba55ddef9db5abdff2024-04-16T21:46:15ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-10-0128448466In vitro and in vivo study on fine-grained Mg–Zn–RE–Zr alloy as a biodegradeable orthopedic implant produced by friction stir processingVasanth C. Shunmugasamy0Marwa AbdelGawad1Muhammad Umar Sohail2Talal Ibrahim3Talha Khan4Thomas Daniel Seers5Bilal Mansoor6Mechanical Engineering Program, Texas A&M University at Qatar, Education City, Doha, QatarMechanical Engineering Program, Texas A&M University at Qatar, Education City, Doha, Qatar; Department of Mechanical Engineering, Texas A&M University, 3123 TAMU, College Station, TX 77843, USAProteomics Core, Weill Cornell Medicine, Education City, Doha, QatarDepartment of Surgery, Division of Orthopedic Surgery, Sidra Medicine, Doha, Qatar; Clinical Orthopedic Surgery, Weill Cornell Medicine, Education City, Doha, QatarPetroleum Engineering Program, Texas A&M University at Qatar, Education City, Doha, QatarPetroleum Engineering Program, Texas A&M University at Qatar, Education City, Doha, QatarMechanical Engineering Program, Texas A&M University at Qatar, Education City, Doha, Qatar; Department of Mechanical Engineering, Texas A&M University, 3123 TAMU, College Station, TX 77843, USA; Department of Materials Science and Engineering, Texas A&M University, 3003 TAMU, College Station, TX 77843, USA; Corresponding author. Mechanical Engineering Program, Texas A&M University at Qatar, Education City, Doha, Qatar.Magnesium alloys containing biocompatible components show tremendous promise for applications as temporary biomedical devices. However, to ensure their safe use as biodegradeable implants, it is essential to control their corrosion rates. In concentrated Mg alloys, a microgalvanic coupling between the α-Mg matrix and secondary precipitates exists which results in increased corrosion rate. To address this challenge, we engineered the microstructure of a biodegradable Mg–Zn–RE–Zr alloy by friction stir processing (FSP), improving its corrosion resistance and mechanical properties simultaneously. The FS processed alloy with refined grains and broken and uniformly distributed secondary precipitates showed a relatively uniform corrosion morphology accompanied with the formation of a stable passive layer on the alloy surface. In vivo corrosion evaluation of the processed alloy in a small animal model showed that the material was well-tolerated with no signs of inflammation or harmful by-products. Remarkably, the processed alloy supported bone until it healed till eight weeks with a low in vivo corrosion rate of 0.7 mm/year. Moreover, we analyzed blood and histology of the critical organs such as liver and kidney, which showed normal functionality and consistent ion and enzyme levels, throughout the 12-week study period. These results demonstrate that the processed Mg–Zn–RE–Zr alloy offers promising potential for osseointegration in bone tissue healing while also exhibiting controlled biodegradability due to its engineered microstructure. The results from the present study will have profound benefit for bone fracture management, particularly in pediatric and elderly patients.http://www.sciencedirect.com/science/article/pii/S2452199X23001913Biodegradable magnesiumBone healingFriction stir processingMicrostructureCorrosion resistance |
| spellingShingle | Vasanth C. Shunmugasamy Marwa AbdelGawad Muhammad Umar Sohail Talal Ibrahim Talha Khan Thomas Daniel Seers Bilal Mansoor In vitro and in vivo study on fine-grained Mg–Zn–RE–Zr alloy as a biodegradeable orthopedic implant produced by friction stir processing Bioactive Materials Biodegradable magnesium Bone healing Friction stir processing Microstructure Corrosion resistance |
| title | In vitro and in vivo study on fine-grained Mg–Zn–RE–Zr alloy as a biodegradeable orthopedic implant produced by friction stir processing |
| title_full | In vitro and in vivo study on fine-grained Mg–Zn–RE–Zr alloy as a biodegradeable orthopedic implant produced by friction stir processing |
| title_fullStr | In vitro and in vivo study on fine-grained Mg–Zn–RE–Zr alloy as a biodegradeable orthopedic implant produced by friction stir processing |
| title_full_unstemmed | In vitro and in vivo study on fine-grained Mg–Zn–RE–Zr alloy as a biodegradeable orthopedic implant produced by friction stir processing |
| title_short | In vitro and in vivo study on fine-grained Mg–Zn–RE–Zr alloy as a biodegradeable orthopedic implant produced by friction stir processing |
| title_sort | in vitro and in vivo study on fine grained mg zn re zr alloy as a biodegradeable orthopedic implant produced by friction stir processing |
| topic | Biodegradable magnesium Bone healing Friction stir processing Microstructure Corrosion resistance |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X23001913 |
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