Sustainable gambogic acid release via pH/Redox Dual-Responsive C60-Modified magnetic mesoporous nanospheres for antitumor therapy
Traditional cancer treatment modalities such as surgery, chemotherapy, and radiation therapy have seen significant advancements in the past. However, inherent drawbacks, including systemic toxicity and high recurrence rates. Consequently, The nanoparticles, with their targeting and multifunctionalit...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-05-01
|
| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127524002843 |
| _version_ | 1797214871138336768 |
|---|---|
| author | Wei-wei Huan Mengyang Dong Ziling Chang Huafei Li Wei Liu Yuxiang Yang Hongmin Yuan Yan Huang Wenwen Liu Riccardo Carlini Mo Chen |
| author_facet | Wei-wei Huan Mengyang Dong Ziling Chang Huafei Li Wei Liu Yuxiang Yang Hongmin Yuan Yan Huang Wenwen Liu Riccardo Carlini Mo Chen |
| author_sort | Wei-wei Huan |
| collection | DOAJ |
| description | Traditional cancer treatment modalities such as surgery, chemotherapy, and radiation therapy have seen significant advancements in the past. However, inherent drawbacks, including systemic toxicity and high recurrence rates. Consequently, The nanoparticles, with their targeting and multifunctionality, have captured significant attention. This work synthesizes HMNPs-C60-N-GQDs-SS-PEI (HMNPs:Fe3O4@SiO2@mSiO2-C18) nanoparticles, integrating diverse functionalities for enhanced cancer therapy. The inclusion of SiO2 and C60 significantly improves the loading efficiency of gallic acid (GA). The magnetic properties of HMNPs enable efficient targeting to cancer sites under external magnetic fields. The -SS- linkage ensures drug release exclusively in tumor cells over-expressing glutathione (GSH), minimizing adverse effects on normal tissues. Introduction of Polyethyleneimine (PEI) imparts positive charge to facilitate accumulation on negatively charged tumor surfaces and enhances biocompatibility. Additionally, the fluorescence properties of N-doped graphene quantum dots (N-GQDs) facilitate real-time monitoring of material distribution in vivo during mouse and clinical therapy. Furthermore, the nano-magnetic targeting material demonstrates efficient drug loading and precise control over drug release, addressing issues such as the poor biocompatibility and high biotoxicity associated with traditional materials. This study not only achieves effective tumor treatment but also offers a promising direction for developing efficient multifunctional nano-targeting materials. |
| first_indexed | 2024-04-24T11:21:03Z |
| format | Article |
| id | doaj.art-1a517bb3901e442da8a104bc873fcb00 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-24T11:21:03Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-1a517bb3901e442da8a104bc873fcb002024-04-11T04:40:48ZengElsevierMaterials & Design0264-12752024-05-01241112911Sustainable gambogic acid release via pH/Redox Dual-Responsive C60-Modified magnetic mesoporous nanospheres for antitumor therapyWei-wei Huan0Mengyang Dong1Ziling Chang2Huafei Li3Wei Liu4Yuxiang Yang5Hongmin Yuan6Yan Huang7Wenwen Liu8Riccardo Carlini9Mo Chen10College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou, Zhejiang 311300, ChinaSchool of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, ChinaSchool of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, ChinaSchool of Lifesciences, Shanghai University, 333 Nanchen Road, Shanghai, ChinaCollege of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou, Zhejiang 311300, ChinaSchool of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China; Corresponding authors.State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130012, ChinaSchool of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, ChinaSchool of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130012, China; Chemistry and Material Chemistry Department, LAS Klee-Barabino, 16146 Genova, Italy; Corresponding authors.College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou, Zhejiang 311300, ChinaTraditional cancer treatment modalities such as surgery, chemotherapy, and radiation therapy have seen significant advancements in the past. However, inherent drawbacks, including systemic toxicity and high recurrence rates. Consequently, The nanoparticles, with their targeting and multifunctionality, have captured significant attention. This work synthesizes HMNPs-C60-N-GQDs-SS-PEI (HMNPs:Fe3O4@SiO2@mSiO2-C18) nanoparticles, integrating diverse functionalities for enhanced cancer therapy. The inclusion of SiO2 and C60 significantly improves the loading efficiency of gallic acid (GA). The magnetic properties of HMNPs enable efficient targeting to cancer sites under external magnetic fields. The -SS- linkage ensures drug release exclusively in tumor cells over-expressing glutathione (GSH), minimizing adverse effects on normal tissues. Introduction of Polyethyleneimine (PEI) imparts positive charge to facilitate accumulation on negatively charged tumor surfaces and enhances biocompatibility. Additionally, the fluorescence properties of N-doped graphene quantum dots (N-GQDs) facilitate real-time monitoring of material distribution in vivo during mouse and clinical therapy. Furthermore, the nano-magnetic targeting material demonstrates efficient drug loading and precise control over drug release, addressing issues such as the poor biocompatibility and high biotoxicity associated with traditional materials. This study not only achieves effective tumor treatment but also offers a promising direction for developing efficient multifunctional nano-targeting materials.http://www.sciencedirect.com/science/article/pii/S0264127524002843Spherical materialpH responseRedox responseMagnetic targeted therapyGambogic acid |
| spellingShingle | Wei-wei Huan Mengyang Dong Ziling Chang Huafei Li Wei Liu Yuxiang Yang Hongmin Yuan Yan Huang Wenwen Liu Riccardo Carlini Mo Chen Sustainable gambogic acid release via pH/Redox Dual-Responsive C60-Modified magnetic mesoporous nanospheres for antitumor therapy Materials & Design Spherical material pH response Redox response Magnetic targeted therapy Gambogic acid |
| title | Sustainable gambogic acid release via pH/Redox Dual-Responsive C60-Modified magnetic mesoporous nanospheres for antitumor therapy |
| title_full | Sustainable gambogic acid release via pH/Redox Dual-Responsive C60-Modified magnetic mesoporous nanospheres for antitumor therapy |
| title_fullStr | Sustainable gambogic acid release via pH/Redox Dual-Responsive C60-Modified magnetic mesoporous nanospheres for antitumor therapy |
| title_full_unstemmed | Sustainable gambogic acid release via pH/Redox Dual-Responsive C60-Modified magnetic mesoporous nanospheres for antitumor therapy |
| title_short | Sustainable gambogic acid release via pH/Redox Dual-Responsive C60-Modified magnetic mesoporous nanospheres for antitumor therapy |
| title_sort | sustainable gambogic acid release via ph redox dual responsive c60 modified magnetic mesoporous nanospheres for antitumor therapy |
| topic | Spherical material pH response Redox response Magnetic targeted therapy Gambogic acid |
| url | http://www.sciencedirect.com/science/article/pii/S0264127524002843 |
| work_keys_str_mv | AT weiweihuan sustainablegambogicacidreleaseviaphredoxdualresponsivec60modifiedmagneticmesoporousnanospheresforantitumortherapy AT mengyangdong sustainablegambogicacidreleaseviaphredoxdualresponsivec60modifiedmagneticmesoporousnanospheresforantitumortherapy AT zilingchang sustainablegambogicacidreleaseviaphredoxdualresponsivec60modifiedmagneticmesoporousnanospheresforantitumortherapy AT huafeili sustainablegambogicacidreleaseviaphredoxdualresponsivec60modifiedmagneticmesoporousnanospheresforantitumortherapy AT weiliu sustainablegambogicacidreleaseviaphredoxdualresponsivec60modifiedmagneticmesoporousnanospheresforantitumortherapy AT yuxiangyang sustainablegambogicacidreleaseviaphredoxdualresponsivec60modifiedmagneticmesoporousnanospheresforantitumortherapy AT hongminyuan sustainablegambogicacidreleaseviaphredoxdualresponsivec60modifiedmagneticmesoporousnanospheresforantitumortherapy AT yanhuang sustainablegambogicacidreleaseviaphredoxdualresponsivec60modifiedmagneticmesoporousnanospheresforantitumortherapy AT wenwenliu sustainablegambogicacidreleaseviaphredoxdualresponsivec60modifiedmagneticmesoporousnanospheresforantitumortherapy AT riccardocarlini sustainablegambogicacidreleaseviaphredoxdualresponsivec60modifiedmagneticmesoporousnanospheresforantitumortherapy AT mochen sustainablegambogicacidreleaseviaphredoxdualresponsivec60modifiedmagneticmesoporousnanospheresforantitumortherapy |