<i>N</i>-Directed Pd-Catalyzed Photoredox-Mediated C–H Arylation for Accessing Phenyl-Extended Analogues of Biginelli/Suzuki-Derived Ethyl 4-Methyl-2,6-diphenylpyrimidine-5-carboxylates

<i>N</i>-Directed Pd-Catalyzed Photoredox-Mediated C–H Arylation for Accessing Phenyl-Extended Analogues of Biginelli/Suzuki-Derived Ethyl 4-Methyl-2,6-diphenylpyrimidine-5-carboxylates

The availability and application of direct, functional group-compatible C–H activation methods for late-stage modification of small-molecule bioactives and other valuable materials remains an ongoing challenge in organic synthesis. In the current study, we demonstrate that a LED-activated, photoredo...

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Bibliographic Details
Main Authors: Savvas N. Georgiades, Persefoni G. Nicolaou, Nikos Panagiotou
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Catalysts
Subjects:
C–H arylation
photoredox catalysis
LED
Suzuki-Miyaura C–C cross-coupling
Biginelli reaction
pyrimidine-based compound library
Online Access:https://www.mdpi.com/2073-4344/11/9/1071

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