Perinatal Factors Associated with Spontaneous Regression of Retinopathy of Prematurity One Year Experience from a Tertiary Care Hospital
Introduction: Spontaneous regression of Retinopathy of Prematurity (ROP) usually happens without serious residual sequelae in most neonates, while in some, blindness or serious visual impairment results from severe ROP. Aim: The aim of the study was to estimate the incidences of ROP that spontaneo...
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| Format: | Article |
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JCDR Research and Publications Pvt. Ltd.
2020-07-01
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| Series: | Indian Journal of Neonatal Medicine and Research |
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| Online Access: | http://www.ijnmr.net/articles/PDF/2273/44677_CE[Ra1]_F(SHU)_PF1(Kri_SHU)_PFA(SHU)_PN(SHU)_PF2_(AS_OM).pdf |
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| author | P KUMAR K S KUMARAVEL D SATHEESHKUMAR S GOBINATHAN P SAMPATHKUMAR K VELMURUGAN |
| author_facet | P KUMAR K S KUMARAVEL D SATHEESHKUMAR S GOBINATHAN P SAMPATHKUMAR K VELMURUGAN |
| author_sort | P KUMAR |
| collection | DOAJ |
| description | Introduction: Spontaneous regression of Retinopathy of Prematurity (ROP) usually happens without serious residual sequelae in most neonates, while in some, blindness or serious visual impairment results from severe ROP.
Aim: The aim of the study was to estimate the incidences of ROP that spontaneously regress and ROP that requires intervention and to identify the perinatal factors that are associated with spontaneous regression of ROP.
Materials and Methods: This is a one year prospective descriptive study done in the Special Newborn Care Unit of a tertiary care hospital. All neonates diagnosed to have ROP of any stage on screening were included in the study. All these neonates were followed-up weekly for progression or regression of ROP. Data collected from case records included demographic, perinatal and neonatal profile of the study participants. The study group was divided into two groups – those neonates with spontaneous regression of ROP (Group 1) and those neonates who had severe ROP requiring intervention (Group 2).
Results: The incidence of ROP was 22.89%. The incidences of ROP spontaneously regressing and ROP requiring intervention were 93.5% and 6.5%, respectively. The univariate analysis of the factors showed a positive Odds Ratio (OR) for spontaneous regression for male gender, multiparity, lower segment caesarian section delivery and increasing gestational age. The OR was negative for factors like maternal anaemia, neonatal Respiratory Distress Syndrome (RDS), neonatal sepsis, phototherapy usage, neonatal blood transfusion, neonatal Intraventricular Hemorrhage (IVH) and increasing oxygen days. The Chi-square test revealed a significant p-value (<0.05) for the factors including IVH (p=0.002), gestational age (p=0.01), birth weight (p=0.01) and oxygen days (p=0.003).
Conclusion: The present study reiterates the need to develop a statistical model or a scoring system to predict the need for intervention in neonates with ROP by doing a larger multicentric study |
| first_indexed | 2024-12-19T14:16:33Z |
| format | Article |
| id | doaj.art-1a53f19452db4b89b7a89ea0fd68282d |
| institution | Directory Open Access Journal |
| issn | 2277-8527 2455-6890 |
| language | English |
| last_indexed | 2024-12-19T14:16:33Z |
| publishDate | 2020-07-01 |
| publisher | JCDR Research and Publications Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Neonatal Medicine and Research |
| spelling | doaj.art-1a53f19452db4b89b7a89ea0fd68282d2022-12-21T20:17:58ZengJCDR Research and Publications Pvt. Ltd.Indian Journal of Neonatal Medicine and Research2277-85272455-68902020-07-0183172210.7860/IJNMR/2020/44677.2273Perinatal Factors Associated with Spontaneous Regression of Retinopathy of Prematurity One Year Experience from a Tertiary Care HospitalP KUMAR0K S KUMARAVEL1D SATHEESHKUMAR2 S GOBINATHAN3P SAMPATHKUMAR4K VELMURUGAN5Assistant Professor, Department of Paediatrics, Govt Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India. Professor, Department of Paediatrics, Govt Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India.Assistant Professor, Department of Paediatrics, Govt Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, IndiaAssociate Professor, Department of Paediatrics, Govt Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, IndiaProfessor, Department of Paediatrics, Govt Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, IndiaJunior Resident, Department of Paediatrics, Govt Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India.Introduction: Spontaneous regression of Retinopathy of Prematurity (ROP) usually happens without serious residual sequelae in most neonates, while in some, blindness or serious visual impairment results from severe ROP. Aim: The aim of the study was to estimate the incidences of ROP that spontaneously regress and ROP that requires intervention and to identify the perinatal factors that are associated with spontaneous regression of ROP. Materials and Methods: This is a one year prospective descriptive study done in the Special Newborn Care Unit of a tertiary care hospital. All neonates diagnosed to have ROP of any stage on screening were included in the study. All these neonates were followed-up weekly for progression or regression of ROP. Data collected from case records included demographic, perinatal and neonatal profile of the study participants. The study group was divided into two groups – those neonates with spontaneous regression of ROP (Group 1) and those neonates who had severe ROP requiring intervention (Group 2). Results: The incidence of ROP was 22.89%. The incidences of ROP spontaneously regressing and ROP requiring intervention were 93.5% and 6.5%, respectively. The univariate analysis of the factors showed a positive Odds Ratio (OR) for spontaneous regression for male gender, multiparity, lower segment caesarian section delivery and increasing gestational age. The OR was negative for factors like maternal anaemia, neonatal Respiratory Distress Syndrome (RDS), neonatal sepsis, phototherapy usage, neonatal blood transfusion, neonatal Intraventricular Hemorrhage (IVH) and increasing oxygen days. The Chi-square test revealed a significant p-value (<0.05) for the factors including IVH (p=0.002), gestational age (p=0.01), birth weight (p=0.01) and oxygen days (p=0.003). Conclusion: The present study reiterates the need to develop a statistical model or a scoring system to predict the need for intervention in neonates with ROP by doing a larger multicentric studyhttp://www.ijnmr.net/articles/PDF/2273/44677_CE[Ra1]_F(SHU)_PF1(Kri_SHU)_PFA(SHU)_PN(SHU)_PF2_(AS_OM).pdflow birth weightneonateoxygenpretermrisk factors |
| spellingShingle | P KUMAR K S KUMARAVEL D SATHEESHKUMAR S GOBINATHAN P SAMPATHKUMAR K VELMURUGAN Perinatal Factors Associated with Spontaneous Regression of Retinopathy of Prematurity One Year Experience from a Tertiary Care Hospital Indian Journal of Neonatal Medicine and Research low birth weight neonate oxygen preterm risk factors |
| title | Perinatal Factors Associated with Spontaneous Regression of Retinopathy of Prematurity One Year Experience from a Tertiary Care Hospital |
| title_full | Perinatal Factors Associated with Spontaneous Regression of Retinopathy of Prematurity One Year Experience from a Tertiary Care Hospital |
| title_fullStr | Perinatal Factors Associated with Spontaneous Regression of Retinopathy of Prematurity One Year Experience from a Tertiary Care Hospital |
| title_full_unstemmed | Perinatal Factors Associated with Spontaneous Regression of Retinopathy of Prematurity One Year Experience from a Tertiary Care Hospital |
| title_short | Perinatal Factors Associated with Spontaneous Regression of Retinopathy of Prematurity One Year Experience from a Tertiary Care Hospital |
| title_sort | perinatal factors associated with spontaneous regression of retinopathy of prematurity one year experience from a tertiary care hospital |
| topic | low birth weight neonate oxygen preterm risk factors |
| url | http://www.ijnmr.net/articles/PDF/2273/44677_CE[Ra1]_F(SHU)_PF1(Kri_SHU)_PFA(SHU)_PN(SHU)_PF2_(AS_OM).pdf |
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