Genome Instability-Associated Long Non-Coding RNAs Reveal Biomarkers for Glioma Immunotherapy and Prognosis
Genome instability is a hallmark of tumors and is involved in proliferation, invasion, migration, and treatment resistance of many tumors. However, the relationship of genome instability with gliomas remains unclear. Here, we constructed genome instability-derived long non-coding RNA (lncRNA)-based...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.850888/full |
| _version_ | 1818211122890670080 |
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| author | Xinzhuang Wang Hong Zhang Junyi Ye Ming Gao Qiuyi Jiang Tingting Zhao Shengtao Wang Wenbin Mao Kaili Wang Qi Wang Xin Chen Xu Hou Dayong Han |
| author_facet | Xinzhuang Wang Hong Zhang Junyi Ye Ming Gao Qiuyi Jiang Tingting Zhao Shengtao Wang Wenbin Mao Kaili Wang Qi Wang Xin Chen Xu Hou Dayong Han |
| author_sort | Xinzhuang Wang |
| collection | DOAJ |
| description | Genome instability is a hallmark of tumors and is involved in proliferation, invasion, migration, and treatment resistance of many tumors. However, the relationship of genome instability with gliomas remains unclear. Here, we constructed genome instability-derived long non-coding RNA (lncRNA)-based gene signatures (GILncSig) using genome instability-related lncRNAs derived from somatic mutations. Multiple platforms were used to confirm that the GILncSig were closely related to patient prognosis and clinical characteristics. We found that GILncSig, the glioma microenvironment, and glioma cell DNA methylation-based stemness index (mDNAsi) interacted with each other to form a complex regulatory network. In summary, this study confirmed that GILncSig was an independent prognostic indicator for patients, distinguished high-risk and low-risk groups, and affected immune-cell infiltration and tumor-cell stemness indicators (mDNAsi) in the tumor microenvironment, resulting in tumor heterogeneity and immunotherapy resistance. GILncSig are expected to provide new molecular targets for the clinical treatment of patients with gliomas. |
| first_indexed | 2024-12-12T05:27:29Z |
| format | Article |
| id | doaj.art-1a54c6a0f846425dbefda560f1aa61b3 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-12T05:27:29Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-1a54c6a0f846425dbefda560f1aa61b32022-12-22T00:36:25ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-04-011310.3389/fgene.2022.850888850888Genome Instability-Associated Long Non-Coding RNAs Reveal Biomarkers for Glioma Immunotherapy and PrognosisXinzhuang Wang0Hong Zhang1Junyi Ye2Ming Gao3Qiuyi Jiang4Tingting Zhao5Shengtao Wang6Wenbin Mao7Kaili Wang8Qi Wang9Xin Chen10Xu Hou11Dayong Han12Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Hematology, Liaocheng People’s Hospital, Liaocheng, ChinaDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, ChinaBiochip Laboratory, Yantai Yu-Huang-Ding Hospital, Qingdao University, Yantai, ChinaThe First Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaThe First Affiliated Hospital of Harbin Medical University, Harbin, ChinaThe First Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, ChinaGenome instability is a hallmark of tumors and is involved in proliferation, invasion, migration, and treatment resistance of many tumors. However, the relationship of genome instability with gliomas remains unclear. Here, we constructed genome instability-derived long non-coding RNA (lncRNA)-based gene signatures (GILncSig) using genome instability-related lncRNAs derived from somatic mutations. Multiple platforms were used to confirm that the GILncSig were closely related to patient prognosis and clinical characteristics. We found that GILncSig, the glioma microenvironment, and glioma cell DNA methylation-based stemness index (mDNAsi) interacted with each other to form a complex regulatory network. In summary, this study confirmed that GILncSig was an independent prognostic indicator for patients, distinguished high-risk and low-risk groups, and affected immune-cell infiltration and tumor-cell stemness indicators (mDNAsi) in the tumor microenvironment, resulting in tumor heterogeneity and immunotherapy resistance. GILncSig are expected to provide new molecular targets for the clinical treatment of patients with gliomas.https://www.frontiersin.org/articles/10.3389/fgene.2022.850888/fullgliomagenome instabilitylncRNAtumor microenvironmentMDNAsiTCGA |
| spellingShingle | Xinzhuang Wang Hong Zhang Junyi Ye Ming Gao Qiuyi Jiang Tingting Zhao Shengtao Wang Wenbin Mao Kaili Wang Qi Wang Xin Chen Xu Hou Dayong Han Genome Instability-Associated Long Non-Coding RNAs Reveal Biomarkers for Glioma Immunotherapy and Prognosis Frontiers in Genetics glioma genome instability lncRNA tumor microenvironment MDNAsi TCGA |
| title | Genome Instability-Associated Long Non-Coding RNAs Reveal Biomarkers for Glioma Immunotherapy and Prognosis |
| title_full | Genome Instability-Associated Long Non-Coding RNAs Reveal Biomarkers for Glioma Immunotherapy and Prognosis |
| title_fullStr | Genome Instability-Associated Long Non-Coding RNAs Reveal Biomarkers for Glioma Immunotherapy and Prognosis |
| title_full_unstemmed | Genome Instability-Associated Long Non-Coding RNAs Reveal Biomarkers for Glioma Immunotherapy and Prognosis |
| title_short | Genome Instability-Associated Long Non-Coding RNAs Reveal Biomarkers for Glioma Immunotherapy and Prognosis |
| title_sort | genome instability associated long non coding rnas reveal biomarkers for glioma immunotherapy and prognosis |
| topic | glioma genome instability lncRNA tumor microenvironment MDNAsi TCGA |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.850888/full |
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