Myelinosome Organelles in the Retina of R6/1 Huntington Disease (HD) Mice: Ubiquitous Distribution and Possible Role in Disease Spreading

Myelinosome Organelles in the Retina of R6/1 Huntington Disease (HD) Mice: Ubiquitous Distribution and Possible Role in Disease Spreading

Visual deficit is one of the complications of Huntington disease (HD), a fatal neurological disorder caused by CAG trinucleotide expansions in the <i>Huntingtin</i> gene, leading to the production of mutant Huntingtin (mHTT) protein. Transgenic HD R6/1 mice expressing human HTT exon1 wit...

Full description

Bibliographic Details
Main Authors: Marina G. Yefimova, Emile Béré, Anne Cantereau-Becq, Annie-Claire Meunier-Balandre, Bruno Merceron, Agnès Burel, Karine Merienne, Célia Ravel, Frédéric Becq, Nicolas Bourmeyster
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
myelinosomes
retina
glial Müller cells
mutant Huntingtin
Huntington disease
membrane fusion
Online Access:https://www.mdpi.com/1422-0067/22/23/12771

Similar Items

Similar Items