The prognostic value of total T3 after acute cerebral infarction is age-dependent: a retrospective study on 768 patients
Abstract Background Serum triiodothyronine (T3) concentration was reported to be associated with the prognosis after acute ischemic stroke. The aim of this study was to evaluate the effect of age on the prognostic value of thyroid-related hormones after an acute ischemic stroke. Methods This was a r...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-04-01
|
| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12883-019-1264-z |
| _version_ | 1828944338364661760 |
|---|---|
| author | Lei-Qing Li Xiao-Yan Xu Wen-Yu Li Xing-Yue Hu Wen Lv |
| author_facet | Lei-Qing Li Xiao-Yan Xu Wen-Yu Li Xing-Yue Hu Wen Lv |
| author_sort | Lei-Qing Li |
| collection | DOAJ |
| description | Abstract Background Serum triiodothyronine (T3) concentration was reported to be associated with the prognosis after acute ischemic stroke. The aim of this study was to evaluate the effect of age on the prognostic value of thyroid-related hormones after an acute ischemic stroke. Methods This was a retrospective study involving the review of 1072 ischemic stroke patients who had been consecutively admitted to the hospital within 72 h of symptom onset. Total triiodothyronine (T3), total thyroxine (T4), free T3, free T4, and thyroid-stimulating hormone (TSH) were assessed to determine their values for predicting functional outcome at the first follow-up clinic visits, which usually occurred 2 to 4 weeks after discharge from the hospital. Results A total of 768 patients were finally included in the study and divided into two age groups: a younger group (age < 65 years) and an older group (age ≥ 65 years). On univariate analysis, four factors—lower total T3, free T3 concentrations, higher scores on the National Institute of Health Stroke Scale (NIHSS) and the presence of atrial fibrillation—were associated with poor functional outcomes in both groups. In addition, older age, female gender, higher free T4, and lower TSH levels were also associated with poor function in the older group. On multiple logistic regression analysis, higher NIHSS scores (odds ratio [OR] =1.95; 95% confidence interval [CI], 1.66–2.30; P ≤ .001) and lower total T3 concentrations (OR = 0.06; 95% CI, 0.01–0.68; P = .024) remained independently associated with poor functional outcome in the older group. However, the independent association with poor function of lower total T3 was not confirmed in the younger group. Conclusions The prognostic value of low total T3 is age-associated and more meaningful in an older population. |
| first_indexed | 2024-12-14T04:32:01Z |
| format | Article |
| id | doaj.art-1a574d8da1c647229201e5725d4b4ade |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-14T04:32:01Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-1a574d8da1c647229201e5725d4b4ade2022-12-21T23:17:03ZengBMCBMC Neurology1471-23772019-04-011911710.1186/s12883-019-1264-zThe prognostic value of total T3 after acute cerebral infarction is age-dependent: a retrospective study on 768 patientsLei-Qing Li0Xiao-Yan Xu1Wen-Yu Li2Xing-Yue Hu3Wen Lv4Department of Intensive Care Unit, the Second Affiliated Hospital, Zhejiang University School of Medicine, HangzhouDepartment of Neurology, the Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Neurology, the Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Neurology, the Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Neurology, the Sir Run Run Shaw Hospital, Zhejiang University School of MedicineAbstract Background Serum triiodothyronine (T3) concentration was reported to be associated with the prognosis after acute ischemic stroke. The aim of this study was to evaluate the effect of age on the prognostic value of thyroid-related hormones after an acute ischemic stroke. Methods This was a retrospective study involving the review of 1072 ischemic stroke patients who had been consecutively admitted to the hospital within 72 h of symptom onset. Total triiodothyronine (T3), total thyroxine (T4), free T3, free T4, and thyroid-stimulating hormone (TSH) were assessed to determine their values for predicting functional outcome at the first follow-up clinic visits, which usually occurred 2 to 4 weeks after discharge from the hospital. Results A total of 768 patients were finally included in the study and divided into two age groups: a younger group (age < 65 years) and an older group (age ≥ 65 years). On univariate analysis, four factors—lower total T3, free T3 concentrations, higher scores on the National Institute of Health Stroke Scale (NIHSS) and the presence of atrial fibrillation—were associated with poor functional outcomes in both groups. In addition, older age, female gender, higher free T4, and lower TSH levels were also associated with poor function in the older group. On multiple logistic regression analysis, higher NIHSS scores (odds ratio [OR] =1.95; 95% confidence interval [CI], 1.66–2.30; P ≤ .001) and lower total T3 concentrations (OR = 0.06; 95% CI, 0.01–0.68; P = .024) remained independently associated with poor functional outcome in the older group. However, the independent association with poor function of lower total T3 was not confirmed in the younger group. Conclusions The prognostic value of low total T3 is age-associated and more meaningful in an older population.http://link.springer.com/article/10.1186/s12883-019-1264-zThyroid-related hormonesIschemic strokeFunctional outcome |
| spellingShingle | Lei-Qing Li Xiao-Yan Xu Wen-Yu Li Xing-Yue Hu Wen Lv The prognostic value of total T3 after acute cerebral infarction is age-dependent: a retrospective study on 768 patients BMC Neurology Thyroid-related hormones Ischemic stroke Functional outcome |
| title | The prognostic value of total T3 after acute cerebral infarction is age-dependent: a retrospective study on 768 patients |
| title_full | The prognostic value of total T3 after acute cerebral infarction is age-dependent: a retrospective study on 768 patients |
| title_fullStr | The prognostic value of total T3 after acute cerebral infarction is age-dependent: a retrospective study on 768 patients |
| title_full_unstemmed | The prognostic value of total T3 after acute cerebral infarction is age-dependent: a retrospective study on 768 patients |
| title_short | The prognostic value of total T3 after acute cerebral infarction is age-dependent: a retrospective study on 768 patients |
| title_sort | prognostic value of total t3 after acute cerebral infarction is age dependent a retrospective study on 768 patients |
| topic | Thyroid-related hormones Ischemic stroke Functional outcome |
| url | http://link.springer.com/article/10.1186/s12883-019-1264-z |
| work_keys_str_mv | AT leiqingli theprognosticvalueoftotalt3afteracutecerebralinfarctionisagedependentaretrospectivestudyon768patients AT xiaoyanxu theprognosticvalueoftotalt3afteracutecerebralinfarctionisagedependentaretrospectivestudyon768patients AT wenyuli theprognosticvalueoftotalt3afteracutecerebralinfarctionisagedependentaretrospectivestudyon768patients AT xingyuehu theprognosticvalueoftotalt3afteracutecerebralinfarctionisagedependentaretrospectivestudyon768patients AT wenlv theprognosticvalueoftotalt3afteracutecerebralinfarctionisagedependentaretrospectivestudyon768patients AT leiqingli prognosticvalueoftotalt3afteracutecerebralinfarctionisagedependentaretrospectivestudyon768patients AT xiaoyanxu prognosticvalueoftotalt3afteracutecerebralinfarctionisagedependentaretrospectivestudyon768patients AT wenyuli prognosticvalueoftotalt3afteracutecerebralinfarctionisagedependentaretrospectivestudyon768patients AT xingyuehu prognosticvalueoftotalt3afteracutecerebralinfarctionisagedependentaretrospectivestudyon768patients AT wenlv prognosticvalueoftotalt3afteracutecerebralinfarctionisagedependentaretrospectivestudyon768patients |