Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of Azithromycin
Research to increase the solubility of active pharmaceutical ingredients is usually conducted by reducing the particle size. This research is one side that used the solid dispersion systems to increase solubility, especially on macrolide antibiotics for which there is still little information. The c...
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| Format: | Article |
| Language: | English |
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Magister Program of Material Sciences, Graduate School of Universitas Sriwijaya
2023-10-01
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| Series: | Science and Technology Indonesia |
| Subjects: | |
| Online Access: | https://sciencetechindonesia.com/index.php/jsti/article/view/883/362 |
| _version_ | 1797280148342439936 |
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| author | Mardiyanto Budi Untari Ady Mara Diko Fahri Ferdiansyah |
| author_facet | Mardiyanto Budi Untari Ady Mara Diko Fahri Ferdiansyah |
| author_sort | Mardiyanto |
| collection | DOAJ |
| description | Research to increase the solubility of active pharmaceutical ingredients is usually conducted by reducing the particle size. This research is one side that used the solid dispersion systems to increase solubility, especially on macrolide antibiotics for which there is still little information. The co-grinding technique on azithromycin-chitosan-alginate was chosen to produce a solid dispersion system. The parameters observed were changes in crystal structure, FTIR spectral patterns, morphological changes, and dissolution profile changes. The results of this research showed a change in the pattern of X-diffraction of azithromycin, physical interaction between azithromycin and the polymer, changes in the image of surface of solid dispersions, the solubility of solid dispersions in simulated-intestinal-fluid (SIF) solutions, and an increase in the dissolution rate of azithromycin indicating that the co-grinding technique to produce solid dispersions can increase the solubility of azithromycin. |
| first_indexed | 2024-03-07T16:37:04Z |
| format | Article |
| id | doaj.art-1a5b7d6e3bdb44c2ada6f0e4fdea077a |
| institution | Directory Open Access Journal |
| issn | 2580-4405 2580-4391 |
| language | English |
| last_indexed | 2024-03-07T16:37:04Z |
| publishDate | 2023-10-01 |
| publisher | Magister Program of Material Sciences, Graduate School of Universitas Sriwijaya |
| record_format | Article |
| series | Science and Technology Indonesia |
| spelling | doaj.art-1a5b7d6e3bdb44c2ada6f0e4fdea077a2024-03-03T09:42:46ZengMagister Program of Material Sciences, Graduate School of Universitas SriwijayaScience and Technology Indonesia2580-44052580-43912023-10-018464765310.26554/sti.2023.8.4.647-653Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of AzithromycinMardiyanto0Budi Untari1Ady Mara2Diko Fahri Ferdiansyah3Department of Pharmacy, Faculty of Mathematics and Natural Science, Sriwijaya University, Indralaya, Ogan Ilir, 30662, IndonesiaDepartment of Pharmacy, Faculty of Mathematics and Natural Science, Sriwijaya University, Indralaya, Ogan Ilir, 30662, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Science, Sriwijaya University, Indralaya, Ogan Ilir, 30662, IndonesiaDepartment of Pharmacy, Faculty of Mathematics and Natural Science, Sriwijaya University, Indralaya, Ogan Ilir, 30662, IndonesiaResearch to increase the solubility of active pharmaceutical ingredients is usually conducted by reducing the particle size. This research is one side that used the solid dispersion systems to increase solubility, especially on macrolide antibiotics for which there is still little information. The co-grinding technique on azithromycin-chitosan-alginate was chosen to produce a solid dispersion system. The parameters observed were changes in crystal structure, FTIR spectral patterns, morphological changes, and dissolution profile changes. The results of this research showed a change in the pattern of X-diffraction of azithromycin, physical interaction between azithromycin and the polymer, changes in the image of surface of solid dispersions, the solubility of solid dispersions in simulated-intestinal-fluid (SIF) solutions, and an increase in the dissolution rate of azithromycin indicating that the co-grinding technique to produce solid dispersions can increase the solubility of azithromycin.https://sciencetechindonesia.com/index.php/jsti/article/view/883/362co-grindingsolid-dispersionazithromycinchitosanalginate |
| spellingShingle | Mardiyanto Budi Untari Ady Mara Diko Fahri Ferdiansyah Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of Azithromycin Science and Technology Indonesia co-grinding solid-dispersion azithromycin chitosan alginate |
| title | Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of Azithromycin |
| title_full | Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of Azithromycin |
| title_fullStr | Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of Azithromycin |
| title_full_unstemmed | Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of Azithromycin |
| title_short | Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of Azithromycin |
| title_sort | formation of hydroxyl amide solid dispersion involving azithromycin and chitosan alginate biopolymer to increase the dissolution rate of azithromycin |
| topic | co-grinding solid-dispersion azithromycin chitosan alginate |
| url | https://sciencetechindonesia.com/index.php/jsti/article/view/883/362 |
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