The Effects of Respiratory Vaccine Type and Timing on Antibody Titers, Immunoglobulins, and Growth Performance in Pre- and Post-Weaned Beef Calves
In order to examine the effects of vaccine type and timing of crossbred beef calves (<i>n</i> = 151) were assigned to one of three BRD vaccination protocols stratified by breed of sire, sex, and date of birth, which included: (1) KM—a pentavalent killed viral (KV) vaccine at 2 to 3 month...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/10/1/37 |
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| author | Jeff M. Matty Cassidy Reddout Jordan Adams Mike Major David Lalman Rosslyn Biggs Janeen L. Salak-Johnson Paul A. Beck |
| author_facet | Jeff M. Matty Cassidy Reddout Jordan Adams Mike Major David Lalman Rosslyn Biggs Janeen L. Salak-Johnson Paul A. Beck |
| author_sort | Jeff M. Matty |
| collection | DOAJ |
| description | In order to examine the effects of vaccine type and timing of crossbred beef calves (<i>n</i> = 151) were assigned to one of three BRD vaccination protocols stratified by breed of sire, sex, and date of birth, which included: (1) KM—a pentavalent killed viral (KV) vaccine at 2 to 3 months of age (D 0) and a pentavalent modified-live viral (MLV) vaccine at weaning (D 127); (2) MM—MLV on D 0 and revaccinated on D 127 or (3) WN—MLV at weaning and D 140. Vaccination treatment did not affect performance nor BRSV serum-neutralizing antibody titers. Serum-neutralizing antibody titers to BVDV-1 were greatest for the MM through D 154. However, following booster (KM) or initial vaccination (WN) at D 127, titers increased for the other treatment groups to higher values (KM) by the end of the study. Delay of initial vaccination until weaning may have delayed specific antibody response in the WN group and skewed the immune response towards a Th-1 or cell-mediated response. Overall, the inclusion of an MLV in the vaccine protocol resulted in a more robust antibody response, and the timing of vaccination may affect the onset of efficacious and robust vaccine responses. |
| first_indexed | 2024-03-09T11:03:02Z |
| format | Article |
| id | doaj.art-1a5d22d6b7d8442ea29f7d6f7400ffac |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T11:03:02Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-1a5d22d6b7d8442ea29f7d6f7400ffac2023-12-01T01:07:58ZengMDPI AGVeterinary Sciences2306-73812023-01-011013710.3390/vetsci10010037The Effects of Respiratory Vaccine Type and Timing on Antibody Titers, Immunoglobulins, and Growth Performance in Pre- and Post-Weaned Beef CalvesJeff M. Matty0Cassidy Reddout1Jordan Adams2Mike Major3David Lalman4Rosslyn Biggs5Janeen L. Salak-Johnson6Paul A. Beck7Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK 74078, USADepartment of Animal and Food Sciences, Oklahoma State University, Stillwater, OK 74078, USADepartment of Animal Science, Texas A&M University, College Station, TX 77843, USADepartment of Animal and Food Sciences, Oklahoma State University, Stillwater, OK 74078, USADepartment of Animal and Food Sciences, Oklahoma State University, Stillwater, OK 74078, USAVeterinary Clinical Sciences Department, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USADepartment of Animal and Food Sciences, Oklahoma State University, Stillwater, OK 74078, USADepartment of Animal and Food Sciences, Oklahoma State University, Stillwater, OK 74078, USAIn order to examine the effects of vaccine type and timing of crossbred beef calves (<i>n</i> = 151) were assigned to one of three BRD vaccination protocols stratified by breed of sire, sex, and date of birth, which included: (1) KM—a pentavalent killed viral (KV) vaccine at 2 to 3 months of age (D 0) and a pentavalent modified-live viral (MLV) vaccine at weaning (D 127); (2) MM—MLV on D 0 and revaccinated on D 127 or (3) WN—MLV at weaning and D 140. Vaccination treatment did not affect performance nor BRSV serum-neutralizing antibody titers. Serum-neutralizing antibody titers to BVDV-1 were greatest for the MM through D 154. However, following booster (KM) or initial vaccination (WN) at D 127, titers increased for the other treatment groups to higher values (KM) by the end of the study. Delay of initial vaccination until weaning may have delayed specific antibody response in the WN group and skewed the immune response towards a Th-1 or cell-mediated response. Overall, the inclusion of an MLV in the vaccine protocol resulted in a more robust antibody response, and the timing of vaccination may affect the onset of efficacious and robust vaccine responses.https://www.mdpi.com/2306-7381/10/1/37bovine respiratory diseasebeef calvesweaningpreconditioningvaccination |
| spellingShingle | Jeff M. Matty Cassidy Reddout Jordan Adams Mike Major David Lalman Rosslyn Biggs Janeen L. Salak-Johnson Paul A. Beck The Effects of Respiratory Vaccine Type and Timing on Antibody Titers, Immunoglobulins, and Growth Performance in Pre- and Post-Weaned Beef Calves Veterinary Sciences bovine respiratory disease beef calves weaning preconditioning vaccination |
| title | The Effects of Respiratory Vaccine Type and Timing on Antibody Titers, Immunoglobulins, and Growth Performance in Pre- and Post-Weaned Beef Calves |
| title_full | The Effects of Respiratory Vaccine Type and Timing on Antibody Titers, Immunoglobulins, and Growth Performance in Pre- and Post-Weaned Beef Calves |
| title_fullStr | The Effects of Respiratory Vaccine Type and Timing on Antibody Titers, Immunoglobulins, and Growth Performance in Pre- and Post-Weaned Beef Calves |
| title_full_unstemmed | The Effects of Respiratory Vaccine Type and Timing on Antibody Titers, Immunoglobulins, and Growth Performance in Pre- and Post-Weaned Beef Calves |
| title_short | The Effects of Respiratory Vaccine Type and Timing on Antibody Titers, Immunoglobulins, and Growth Performance in Pre- and Post-Weaned Beef Calves |
| title_sort | effects of respiratory vaccine type and timing on antibody titers immunoglobulins and growth performance in pre and post weaned beef calves |
| topic | bovine respiratory disease beef calves weaning preconditioning vaccination |
| url | https://www.mdpi.com/2306-7381/10/1/37 |
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