Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study
Abstract Background Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods We combined individual...
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| Format: | Article |
| Language: | English |
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BMC
2020-12-01
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| Series: | Alzheimer’s Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13195-020-00734-y |
| _version_ | 1818601235899482112 |
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| author | Susanne Röhr Alexander Pabst Steffi G. Riedel-Heller Frank Jessen Yuda Turana Yvonne S. Handajani Carol Brayne Fiona E. Matthews Blossom C. M. Stephan Richard B. Lipton Mindy J. Katz Cuiling Wang Maëlenn Guerchet Pierre-Marie Preux Pascal Mbelesso Karen Ritchie Marie-Laure Ancelin Isabelle Carrière Antonio Guaita Annalisa Davin Roberta Vaccaro Ki Woong Kim Ji Won Han Seung Wan Suh Suzana Shahar Normah C. Din Divya Vanoh Martin van Boxtel Sebastian Köhler Mary Ganguli Erin P. Jacobsen Beth E. Snitz Kaarin J. Anstey Nicolas Cherbuin Shuzo Kumagai Sanmei Chen Kenji Narazaki Tze Pin Ng Qi Gao Xinyi Gwee Henry Brodaty Nicole A. Kochan Julian Trollor Antonio Lobo Raúl López-Antón Javier Santabárbara John D. Crawford Darren M. Lipnicki Perminder S. Sachdev for Cohort Studies of Memory in an International Consortium (COSMIC) |
| author_facet | Susanne Röhr Alexander Pabst Steffi G. Riedel-Heller Frank Jessen Yuda Turana Yvonne S. Handajani Carol Brayne Fiona E. Matthews Blossom C. M. Stephan Richard B. Lipton Mindy J. Katz Cuiling Wang Maëlenn Guerchet Pierre-Marie Preux Pascal Mbelesso Karen Ritchie Marie-Laure Ancelin Isabelle Carrière Antonio Guaita Annalisa Davin Roberta Vaccaro Ki Woong Kim Ji Won Han Seung Wan Suh Suzana Shahar Normah C. Din Divya Vanoh Martin van Boxtel Sebastian Köhler Mary Ganguli Erin P. Jacobsen Beth E. Snitz Kaarin J. Anstey Nicolas Cherbuin Shuzo Kumagai Sanmei Chen Kenji Narazaki Tze Pin Ng Qi Gao Xinyi Gwee Henry Brodaty Nicole A. Kochan Julian Trollor Antonio Lobo Raúl López-Antón Javier Santabárbara John D. Crawford Darren M. Lipnicki Perminder S. Sachdev for Cohort Studies of Memory in an International Consortium (COSMIC) |
| author_sort | Susanne Röhr |
| collection | DOAJ |
| description | Abstract Background Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence. Results The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3–24.4%) and IRT (25.6%, 95%CI = 25.1–26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1–7.0%, to 52.7%, 95%CI = 47.4–58.0%; IRT: 7.8%, 95%CI = 6.8–8.9%, to 52.7%, 95%CI = 47.4–58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades. Conclusions SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field. |
| first_indexed | 2024-12-16T12:48:10Z |
| format | Article |
| id | doaj.art-1a5e291acc084db192c86258647f4aad |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-12-16T12:48:10Z |
| publishDate | 2020-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-1a5e291acc084db192c86258647f4aad2022-12-21T22:31:13ZengBMCAlzheimer’s Research & Therapy1758-91932020-12-0112111410.1186/s13195-020-00734-yEstimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC studySusanne Röhr0Alexander Pabst1Steffi G. Riedel-Heller2Frank Jessen3Yuda Turana4Yvonne S. Handajani5Carol Brayne6Fiona E. Matthews7Blossom C. M. Stephan8Richard B. Lipton9Mindy J. Katz10Cuiling Wang11Maëlenn Guerchet12Pierre-Marie Preux13Pascal Mbelesso14Karen Ritchie15Marie-Laure Ancelin16Isabelle Carrière17Antonio Guaita18Annalisa Davin19Roberta Vaccaro20Ki Woong Kim21Ji Won Han22Seung Wan Suh23Suzana Shahar24Normah C. Din25Divya Vanoh26Martin van Boxtel27Sebastian Köhler28Mary Ganguli29Erin P. Jacobsen30Beth E. Snitz31Kaarin J. Anstey32Nicolas Cherbuin33Shuzo Kumagai34Sanmei Chen35Kenji Narazaki36Tze Pin Ng37Qi Gao38Xinyi Gwee39Henry Brodaty40Nicole A. Kochan41Julian Trollor42Antonio Lobo43Raúl López-Antón44Javier Santabárbara45John D. Crawford46Darren M. Lipnicki47Perminder S. Sachdev48for Cohort Studies of Memory in an International Consortium (COSMIC)Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of LeipzigInstitute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of LeipzigInstitute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of LeipzigDepartment of Psychiatry, University of Cologne, Medical FacultyDepartment of Neurology, School of Medicine, Atma Jaya Catholic University of IndonesiaCenter for Health Research, School of Medicine, Atma Jaya Catholic University of IndonesiaCambridge Public Health, Cambridge UniversityMRC Biostatistics Unit, Institute of Public Health, Cambridge UniversityInstitute of Health and Society, Newcastle UniversitySaul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva UniversitySaul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva UniversityDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Yeshiva UniversityINSERM, U1094, Tropical NeuroepidemiologyINSERM, U1094, Tropical NeuroepidemiologyINSERM, U1094, Tropical NeuroepidemiologyINSERM U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, Université de MontpellierINSERM U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, Université de MontpellierINSERM U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, Université de MontpellierGolgi Cenci FoundationGolgi Cenci FoundationGolgi Cenci FoundationDepartment of Neuropsychiatry, Seoul National University Bundang HospitalDepartment of Neuropsychiatry, Seoul National University Bundang HospitalDepartment of Psychiatry, Seoul National University College of MedicineCentre of Healthy Aging and Wellness, Faculty of Health Sciences, Universiti Kebangsaan MalaysiaCentre for Rehabilitation Science and Special Needs, Faculty of Health Science, Universiti Kebangsaan MalaysiaSchool of Health Science, Universiti Sains MalaysiaDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Center (MUMC)Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Center (MUMC)Department of Psychiatry, University of Pittsburgh School of MedicineDepartment of Psychiatry, University of Pittsburgh School of MedicineDepartment of Neurology, University of Pittsburgh School of MedicineAgeing Futures Institute, University of New South WalesCentre for Research on Ageing, Health and Wellbeing, College of Health and Medicine, Australian National UniversityCenter for Health Science and Counseling, Kyushu UniversityDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu UniversityFaculty of Socio-Environmental Studies, Department of Socio-Environmental Studies, Fukuoka Institute of TechnologyDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of SingaporeCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales SydneyCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales SydneyCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales SydneyCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and InnovationCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and InnovationCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and InnovationCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales SydneyCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales SydneyCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales SydneyAbstract Background Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence. Results The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3–24.4%) and IRT (25.6%, 95%CI = 25.1–26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1–7.0%, to 52.7%, 95%CI = 47.4–58.0%; IRT: 7.8%, 95%CI = 6.8–8.9%, to 52.7%, 95%CI = 47.4–58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades. Conclusions SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field.https://doi.org/10.1186/s13195-020-00734-ySubjective cognitive declinePrevalenceEpidemiologyIndividual participant dataData harmonizationCohort study |
| spellingShingle | Susanne Röhr Alexander Pabst Steffi G. Riedel-Heller Frank Jessen Yuda Turana Yvonne S. Handajani Carol Brayne Fiona E. Matthews Blossom C. M. Stephan Richard B. Lipton Mindy J. Katz Cuiling Wang Maëlenn Guerchet Pierre-Marie Preux Pascal Mbelesso Karen Ritchie Marie-Laure Ancelin Isabelle Carrière Antonio Guaita Annalisa Davin Roberta Vaccaro Ki Woong Kim Ji Won Han Seung Wan Suh Suzana Shahar Normah C. Din Divya Vanoh Martin van Boxtel Sebastian Köhler Mary Ganguli Erin P. Jacobsen Beth E. Snitz Kaarin J. Anstey Nicolas Cherbuin Shuzo Kumagai Sanmei Chen Kenji Narazaki Tze Pin Ng Qi Gao Xinyi Gwee Henry Brodaty Nicole A. Kochan Julian Trollor Antonio Lobo Raúl López-Antón Javier Santabárbara John D. Crawford Darren M. Lipnicki Perminder S. Sachdev for Cohort Studies of Memory in an International Consortium (COSMIC) Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study Alzheimer’s Research & Therapy Subjective cognitive decline Prevalence Epidemiology Individual participant data Data harmonization Cohort study |
| title | Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study |
| title_full | Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study |
| title_fullStr | Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study |
| title_full_unstemmed | Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study |
| title_short | Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study |
| title_sort | estimating prevalence of subjective cognitive decline in and across international cohort studies of aging a cosmic study |
| topic | Subjective cognitive decline Prevalence Epidemiology Individual participant data Data harmonization Cohort study |
| url | https://doi.org/10.1186/s13195-020-00734-y |
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