Evolution by Pervasive Gene Fusion in Antibiotic Resistance and Antibiotic Synthesizing Genes
Phylogenetic (tree-based) approaches to understanding evolutionary history are unable to incorporate convergent evolutionary events where two genes merge into one. In this study, as exemplars of what can be achieved when a tree is not assumed a priori, we have analysed the evolutionary histories of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-03-01
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| Series: | Computation |
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| Online Access: | http://www.mdpi.com/2079-3197/3/2/114 |
| _version_ | 1818145464915066880 |
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| author | Orla Coleman Ruth Hogan Nicole McGoldrick Niamh Rudden James O. McInerney |
| author_facet | Orla Coleman Ruth Hogan Nicole McGoldrick Niamh Rudden James O. McInerney |
| author_sort | Orla Coleman |
| collection | DOAJ |
| description | Phylogenetic (tree-based) approaches to understanding evolutionary history are unable to incorporate convergent evolutionary events where two genes merge into one. In this study, as exemplars of what can be achieved when a tree is not assumed a priori, we have analysed the evolutionary histories of polyketide synthase genes and antibiotic resistance genes and have shown that their history is replete with convergent events as well as divergent events. We demonstrate that the overall histories of these genes more closely resembles the remodelling that might be seen with the children’s toy Lego, than the standard model of the phylogenetic tree. This work demonstrates further that genes can act as public goods, available for re-use and incorporation into other genetic goods. |
| first_indexed | 2024-12-11T12:03:53Z |
| format | Article |
| id | doaj.art-1a5fa1636dda4f629cbca9725c383af1 |
| institution | Directory Open Access Journal |
| issn | 2079-3197 |
| language | English |
| last_indexed | 2024-12-11T12:03:53Z |
| publishDate | 2015-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Computation |
| spelling | doaj.art-1a5fa1636dda4f629cbca9725c383af12022-12-22T01:08:00ZengMDPI AGComputation2079-31972015-03-013211412710.3390/computation3020114computation3020114Evolution by Pervasive Gene Fusion in Antibiotic Resistance and Antibiotic Synthesizing GenesOrla Coleman0Ruth Hogan1Nicole McGoldrick2Niamh Rudden3James O. McInerney4Department of Biology, National University of Ireland Maynooth, Co. Kildare, IrelandDepartment of Biology, National University of Ireland Maynooth, Co. Kildare, IrelandDepartment of Biology, National University of Ireland Maynooth, Co. Kildare, IrelandDepartment of Biology, National University of Ireland Maynooth, Co. Kildare, IrelandDepartment of Biology, National University of Ireland Maynooth, Co. Kildare, IrelandPhylogenetic (tree-based) approaches to understanding evolutionary history are unable to incorporate convergent evolutionary events where two genes merge into one. In this study, as exemplars of what can be achieved when a tree is not assumed a priori, we have analysed the evolutionary histories of polyketide synthase genes and antibiotic resistance genes and have shown that their history is replete with convergent events as well as divergent events. We demonstrate that the overall histories of these genes more closely resembles the remodelling that might be seen with the children’s toy Lego, than the standard model of the phylogenetic tree. This work demonstrates further that genes can act as public goods, available for re-use and incorporation into other genetic goods.http://www.mdpi.com/2079-3197/3/2/114polyketidenetworkhomologyevolutionphylogenyconnected componentcommunity structure |
| spellingShingle | Orla Coleman Ruth Hogan Nicole McGoldrick Niamh Rudden James O. McInerney Evolution by Pervasive Gene Fusion in Antibiotic Resistance and Antibiotic Synthesizing Genes Computation polyketide network homology evolution phylogeny connected component community structure |
| title | Evolution by Pervasive Gene Fusion in Antibiotic Resistance and Antibiotic Synthesizing Genes |
| title_full | Evolution by Pervasive Gene Fusion in Antibiotic Resistance and Antibiotic Synthesizing Genes |
| title_fullStr | Evolution by Pervasive Gene Fusion in Antibiotic Resistance and Antibiotic Synthesizing Genes |
| title_full_unstemmed | Evolution by Pervasive Gene Fusion in Antibiotic Resistance and Antibiotic Synthesizing Genes |
| title_short | Evolution by Pervasive Gene Fusion in Antibiotic Resistance and Antibiotic Synthesizing Genes |
| title_sort | evolution by pervasive gene fusion in antibiotic resistance and antibiotic synthesizing genes |
| topic | polyketide network homology evolution phylogeny connected component community structure |
| url | http://www.mdpi.com/2079-3197/3/2/114 |
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