Composite Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma and Epstein-Barr virus-negative diffuse large B-cell lymphoma in the parotid salivary gland of a patient with Sjögren’s syndrome and rheumatoid arthritis: a case report
Abstract Background Epstein-Barr virus is associated with many human hematopoietic neoplasms; however, Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma is extremely rare. In routine clinical practice, detection of mucosa-associated lymphoid tissue lymphoma and diffuse large B-c...
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-019-2331-1 |
| _version_ | 1818735101448552448 |
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| author | Vadim R. Gorodetskiy Natalya A. Probatova Dmitry M. Konovalov Natalya V. Ryzhikova Yulia V. Sidorova Andrey B. Sudarikov Olga V. Mukhortova |
| author_facet | Vadim R. Gorodetskiy Natalya A. Probatova Dmitry M. Konovalov Natalya V. Ryzhikova Yulia V. Sidorova Andrey B. Sudarikov Olga V. Mukhortova |
| author_sort | Vadim R. Gorodetskiy |
| collection | DOAJ |
| description | Abstract Background Epstein-Barr virus is associated with many human hematopoietic neoplasms; however, Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma is extremely rare. In routine clinical practice, detection of mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma in a tissue sample presumes a clonal relation between these neoplasms and that diffuse large B-cell lymphoma developed by transformation of the mucosa-associated lymphoid tissue lymphoma. However, evidence to support this presumption is sparse and controversial. Assessment of the clonal relationship of the lymphoid components of a composite lymphoma is important for understanding its pathogenesis and correct diagnosis. Case presentation We present an unusual case of composite lymphoma (Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma/Epstein-Barr virus-negative diffuse large B-cell lymphoma) in the parotid salivary gland of a 62-year-old Caucasian woman with Sjögren’s syndrome and rheumatoid arthritis. Simultaneous occurrence of mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma in the parotid salivary gland led us to initially assume a clonal relationship between diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma. Epstein-Barr virus was detected by in situ hybridization and polymerase chain reaction in the mucosa-associated lymphoid tissue lymphoma, but not in diffuse large B-cell lymphoma, suggesting that these lymphomas were not clonally related. Fragment analysis of frame region 3 polymerase chain reaction products from microdissected mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma components revealed different clonal pattern rearrangements of the immunoglobulin heavy chain gene. Conclusions Our patient’s case highlights the importance of assessing the clonal relationships of the lymphoid components of a composite lymphoma and Epstein-Barr virus screening in mucosa-associated lymphoid tissue lymphoma in patients with autoimmune disease. |
| first_indexed | 2024-12-18T00:15:54Z |
| format | Article |
| id | doaj.art-1a606985664a49cb937370bf0cd34529 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-18T00:15:54Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-1a606985664a49cb937370bf0cd345292022-12-21T21:27:32ZengBMCJournal of Medical Case Reports1752-19472020-01-011411710.1186/s13256-019-2331-1Composite Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma and Epstein-Barr virus-negative diffuse large B-cell lymphoma in the parotid salivary gland of a patient with Sjögren’s syndrome and rheumatoid arthritis: a case reportVadim R. Gorodetskiy0Natalya A. Probatova1Dmitry M. Konovalov2Natalya V. Ryzhikova3Yulia V. Sidorova4Andrey B. Sudarikov5Olga V. Mukhortova6Department of Intensive Methods of Therapy, V.A. Nasonova Research Institute of RheumatologyDepartment of Pathology, N.N. Blokhin Russian Cancer Research CenterDepartment of Pathology, Dmitry Rogachev Research and Clinical Centre of Pediatric Hematology, Oncology and ImmunologyLaboratory of Molecular Hematology, National Hematology Research CenterLaboratory of Molecular Hematology, National Hematology Research CenterLaboratory of Molecular Hematology, National Hematology Research CenterDepartment of Nuclear Diagnostics, A.N. Bakulev National Medical Research Center of Cardiovascular SurgeryAbstract Background Epstein-Barr virus is associated with many human hematopoietic neoplasms; however, Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma is extremely rare. In routine clinical practice, detection of mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma in a tissue sample presumes a clonal relation between these neoplasms and that diffuse large B-cell lymphoma developed by transformation of the mucosa-associated lymphoid tissue lymphoma. However, evidence to support this presumption is sparse and controversial. Assessment of the clonal relationship of the lymphoid components of a composite lymphoma is important for understanding its pathogenesis and correct diagnosis. Case presentation We present an unusual case of composite lymphoma (Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma/Epstein-Barr virus-negative diffuse large B-cell lymphoma) in the parotid salivary gland of a 62-year-old Caucasian woman with Sjögren’s syndrome and rheumatoid arthritis. Simultaneous occurrence of mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma in the parotid salivary gland led us to initially assume a clonal relationship between diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma. Epstein-Barr virus was detected by in situ hybridization and polymerase chain reaction in the mucosa-associated lymphoid tissue lymphoma, but not in diffuse large B-cell lymphoma, suggesting that these lymphomas were not clonally related. Fragment analysis of frame region 3 polymerase chain reaction products from microdissected mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma components revealed different clonal pattern rearrangements of the immunoglobulin heavy chain gene. Conclusions Our patient’s case highlights the importance of assessing the clonal relationships of the lymphoid components of a composite lymphoma and Epstein-Barr virus screening in mucosa-associated lymphoid tissue lymphoma in patients with autoimmune disease.https://doi.org/10.1186/s13256-019-2331-1Composite lymphomaMucosa-associated lymphoid tissue lymphomaDiffuse large B-cell lymphomaEpstein-Barr virusAutoimmune diseases |
| spellingShingle | Vadim R. Gorodetskiy Natalya A. Probatova Dmitry M. Konovalov Natalya V. Ryzhikova Yulia V. Sidorova Andrey B. Sudarikov Olga V. Mukhortova Composite Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma and Epstein-Barr virus-negative diffuse large B-cell lymphoma in the parotid salivary gland of a patient with Sjögren’s syndrome and rheumatoid arthritis: a case report Journal of Medical Case Reports Composite lymphoma Mucosa-associated lymphoid tissue lymphoma Diffuse large B-cell lymphoma Epstein-Barr virus Autoimmune diseases |
| title | Composite Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma and Epstein-Barr virus-negative diffuse large B-cell lymphoma in the parotid salivary gland of a patient with Sjögren’s syndrome and rheumatoid arthritis: a case report |
| title_full | Composite Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma and Epstein-Barr virus-negative diffuse large B-cell lymphoma in the parotid salivary gland of a patient with Sjögren’s syndrome and rheumatoid arthritis: a case report |
| title_fullStr | Composite Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma and Epstein-Barr virus-negative diffuse large B-cell lymphoma in the parotid salivary gland of a patient with Sjögren’s syndrome and rheumatoid arthritis: a case report |
| title_full_unstemmed | Composite Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma and Epstein-Barr virus-negative diffuse large B-cell lymphoma in the parotid salivary gland of a patient with Sjögren’s syndrome and rheumatoid arthritis: a case report |
| title_short | Composite Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma and Epstein-Barr virus-negative diffuse large B-cell lymphoma in the parotid salivary gland of a patient with Sjögren’s syndrome and rheumatoid arthritis: a case report |
| title_sort | composite epstein barr virus positive mucosa associated lymphoid tissue lymphoma and epstein barr virus negative diffuse large b cell lymphoma in the parotid salivary gland of a patient with sjogren s syndrome and rheumatoid arthritis a case report |
| topic | Composite lymphoma Mucosa-associated lymphoid tissue lymphoma Diffuse large B-cell lymphoma Epstein-Barr virus Autoimmune diseases |
| url | https://doi.org/10.1186/s13256-019-2331-1 |
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