ASSOCIATION OF THROMBOCYTOPENIA AND PROLONGED BLEEDING TIME IN DENGUE WITH THE CLINICAL OUTCOME OF THE PATIENT
Objective: To find out the frequency of thrombocytopenia and prolonged bleeding time in dengue fever and its effect on clinical outcome of patients. Study Design: Cross-sectional study. Place and Duration of Study: The study was conducted, from August 2016 to February 2017 in the Haematology d...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Army Medical College Rawalpindi
2019-10-01
|
| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/3408/2383 |
| _version_ | 1818740497054695424 |
|---|---|
| author | Zareen Irshad Asma Shabbir Asma Shaikh Syed Mehmood Hasan Muhammad Abid |
| author_facet | Zareen Irshad Asma Shabbir Asma Shaikh Syed Mehmood Hasan Muhammad Abid |
| author_sort | Zareen Irshad |
| collection | DOAJ |
| description | Objective: To find out the frequency of thrombocytopenia and prolonged bleeding time in dengue fever and its effect on clinical outcome of patients.
Study Design: Cross-sectional study.
Place and Duration of Study: The study was conducted, from August 2016 to February 2017 in the Haematology department, at Pakistan Naval Ship (PNS) Shifa, Karachi.
Methodology: The study was conducted on serologically proven positive dengue IgM cases fulfilling inclusion and exclusion criteria. Platelet count was done on Beckman Coulter and Sysmex analyzers and then rechecked manually by peripheral blood smear. Bleeding time measured by the Duke method. The clinical outcome was evaluated on the day of discharge (based on survival of the patient and their lab values) or the patient expired
and their lab values.
Results: A total of 135 patients were evaluated in the study. The mean age of the patients was 29.12 ± 13 yrs (range: 2-63 years). The thrombocytopenia was observed in one hundred and eleven (82.2%) patients. Severe thrombocytopenia was observed in nine (6.7%) cases, moderate thrombocytopenia was found in thirty (22.2%) cases and mild thrombocytopenia was observed in seventy-two (53.3%) cases. Bleeding time more than nine minutes was observed only in one case. Out of 135 patients, two (1.48%) expired and one hundred and thirtythree
(98.52%) survived and were discharged.
Conclusion: We observed that platelet count can be a predictor of disease and its progression, but the absence of either cannot be used to exclude the progression of the disease. Dengue continues to be a significant health problem in Pakistan. |
| first_indexed | 2024-12-18T01:41:40Z |
| format | Article |
| id | doaj.art-1a61a11c6dec4e0c802d69cd30bb2f91 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-18T01:41:40Z |
| publishDate | 2019-10-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-1a61a11c6dec4e0c802d69cd30bb2f912022-12-21T21:25:18ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422019-10-0169510291034ASSOCIATION OF THROMBOCYTOPENIA AND PROLONGED BLEEDING TIME IN DENGUE WITH THE CLINICAL OUTCOME OF THE PATIENTZareen Irshad0Asma Shabbir1Asma Shaikh2Syed Mehmood Hasan3Muhammad Abid4Jinnah Sindh Medical University, Karachi PakistanJinnah Sindh Medical University, Karachi PakistanJinnah Sindh Medical University, Karachi PakistanJinnah Sindh Medical University, Karachi PakistanCombined Military Hospital Gilgit PakistanObjective: To find out the frequency of thrombocytopenia and prolonged bleeding time in dengue fever and its effect on clinical outcome of patients. Study Design: Cross-sectional study. Place and Duration of Study: The study was conducted, from August 2016 to February 2017 in the Haematology department, at Pakistan Naval Ship (PNS) Shifa, Karachi. Methodology: The study was conducted on serologically proven positive dengue IgM cases fulfilling inclusion and exclusion criteria. Platelet count was done on Beckman Coulter and Sysmex analyzers and then rechecked manually by peripheral blood smear. Bleeding time measured by the Duke method. The clinical outcome was evaluated on the day of discharge (based on survival of the patient and their lab values) or the patient expired and their lab values. Results: A total of 135 patients were evaluated in the study. The mean age of the patients was 29.12 ± 13 yrs (range: 2-63 years). The thrombocytopenia was observed in one hundred and eleven (82.2%) patients. Severe thrombocytopenia was observed in nine (6.7%) cases, moderate thrombocytopenia was found in thirty (22.2%) cases and mild thrombocytopenia was observed in seventy-two (53.3%) cases. Bleeding time more than nine minutes was observed only in one case. Out of 135 patients, two (1.48%) expired and one hundred and thirtythree (98.52%) survived and were discharged. Conclusion: We observed that platelet count can be a predictor of disease and its progression, but the absence of either cannot be used to exclude the progression of the disease. Dengue continues to be a significant health problem in Pakistan.https://www.pafmj.org/index.php/PAFMJ/article/view/3408/2383bleeding timeclinical outcomedengue |
| spellingShingle | Zareen Irshad Asma Shabbir Asma Shaikh Syed Mehmood Hasan Muhammad Abid ASSOCIATION OF THROMBOCYTOPENIA AND PROLONGED BLEEDING TIME IN DENGUE WITH THE CLINICAL OUTCOME OF THE PATIENT Pakistan Armed Forces Medical Journal bleeding time clinical outcome dengue |
| title | ASSOCIATION OF THROMBOCYTOPENIA AND PROLONGED BLEEDING TIME IN DENGUE WITH THE CLINICAL OUTCOME OF THE PATIENT |
| title_full | ASSOCIATION OF THROMBOCYTOPENIA AND PROLONGED BLEEDING TIME IN DENGUE WITH THE CLINICAL OUTCOME OF THE PATIENT |
| title_fullStr | ASSOCIATION OF THROMBOCYTOPENIA AND PROLONGED BLEEDING TIME IN DENGUE WITH THE CLINICAL OUTCOME OF THE PATIENT |
| title_full_unstemmed | ASSOCIATION OF THROMBOCYTOPENIA AND PROLONGED BLEEDING TIME IN DENGUE WITH THE CLINICAL OUTCOME OF THE PATIENT |
| title_short | ASSOCIATION OF THROMBOCYTOPENIA AND PROLONGED BLEEDING TIME IN DENGUE WITH THE CLINICAL OUTCOME OF THE PATIENT |
| title_sort | association of thrombocytopenia and prolonged bleeding time in dengue with the clinical outcome of the patient |
| topic | bleeding time clinical outcome dengue |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/3408/2383 |
| work_keys_str_mv | AT zareenirshad associationofthrombocytopeniaandprolongedbleedingtimeindenguewiththeclinicaloutcomeofthepatient AT asmashabbir associationofthrombocytopeniaandprolongedbleedingtimeindenguewiththeclinicaloutcomeofthepatient AT asmashaikh associationofthrombocytopeniaandprolongedbleedingtimeindenguewiththeclinicaloutcomeofthepatient AT syedmehmoodhasan associationofthrombocytopeniaandprolongedbleedingtimeindenguewiththeclinicaloutcomeofthepatient AT muhammadabid associationofthrombocytopeniaandprolongedbleedingtimeindenguewiththeclinicaloutcomeofthepatient |