Surgical Innovations in Tracheal Reconstruction: A Review on Synthetic Material Fabrication
<i>Background and Objectives</i>: The aim of this review is to explore the recent surgical innovations in tracheal reconstruction by evaluating the uses of synthetic material fabrication when dealing with tracheomalacia or stenotic pathologies, then discussing the challenges holding back...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/60/1/40 |
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| author | Usman Khalid Petar Uchikov Bozhidar Hristov Krasimir Kraev Maria Koleva-Ivanova Maria Kraeva Atanas Batashki Daniela Taneva Mladen Doykov Angel Uchikov |
| author_facet | Usman Khalid Petar Uchikov Bozhidar Hristov Krasimir Kraev Maria Koleva-Ivanova Maria Kraeva Atanas Batashki Daniela Taneva Mladen Doykov Angel Uchikov |
| author_sort | Usman Khalid |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: The aim of this review is to explore the recent surgical innovations in tracheal reconstruction by evaluating the uses of synthetic material fabrication when dealing with tracheomalacia or stenotic pathologies, then discussing the challenges holding back these innovations. <i>Materials and Methods</i>: A targeted non-systematic review of published literature relating to tracheal reconstruction was performed within the PubMed database to help identify how synthetic materials are utilised to innovate tracheal reconstruction. <i>Results</i>: The advancements in 3D printing to aid synthetic material fabrication have unveiled promising alternatives to conventional approaches. Achieving successful tracheal reconstruction through this technology demands that the 3D models exhibit biocompatibility with neighbouring tracheal elements by encompassing vasculature, chondral foundation, and immunocompatibility. Tracheal reconstruction has employed grafts and scaffolds, showing a promising beginning in vivo. Concurrently, the integration of resorbable models and stem cell therapy serves to underscore their viability and application in the context of tracheal pathologies. Despite this, certain barriers hinder its advancement in surgery. The intricate tracheal structure has posed a challenge for researchers seeking novel approaches to support its growth and regeneration. <i>Conclusions</i>: The potential of synthetic material fabrication has shown promising outcomes in initial studies involving smaller animals. Yet, to fully realise the applicability of these innovative developments, research must progress toward clinical trials. These trials would ascertain the anatomical and physiological effects on the human body, enabling a thorough evaluation of post-operative outcomes and any potential complications linked to the materials or cells implanted in the trachea. |
| first_indexed | 2024-03-08T10:41:01Z |
| format | Article |
| id | doaj.art-1a62cab69fbb4243bd0a8b45db8e137a |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-08T10:41:01Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-1a62cab69fbb4243bd0a8b45db8e137a2024-01-26T17:35:01ZengMDPI AGMedicina1010-660X1648-91442023-12-016014010.3390/medicina60010040Surgical Innovations in Tracheal Reconstruction: A Review on Synthetic Material FabricationUsman Khalid0Petar Uchikov1Bozhidar Hristov2Krasimir Kraev3Maria Koleva-Ivanova4Maria Kraeva5Atanas Batashki6Daniela Taneva7Mladen Doykov8Angel Uchikov9Medical Faculty, Medical University of Plovdiv, 4000 Plovdiv, BulgariaDepartment of Special Surgery, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, BulgariaSection “Gastroenterology”, Second Department of Internal Diseases, Medical Faculty, Medical University of Plovdiv, 4000 Plovdiv, BulgariaDepartment of Propedeutics of Internal Diseases, Medical Faculty, Medical University of Plovdiv, 4000 Plovdiv, BulgariaDepartment of General and Clinical Pathology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, BulgariaDepartment of Otorhynolaryngology, Medical Faculty, Medical University of Plovdiv, 4000 Plovdiv, BulgariaDepartment of Special Surgery, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, BulgariaDepartment of Nursing Care, Faculty of Public Health, Medical University of Plovdiv, 4000 Plovdiv, BulgariaDepartment of Urology and General Medicine, Medical Faculty, Medical University of Plovdiv, 4000 Plovdiv, BulgariaDepartment of Special Surgery, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria<i>Background and Objectives</i>: The aim of this review is to explore the recent surgical innovations in tracheal reconstruction by evaluating the uses of synthetic material fabrication when dealing with tracheomalacia or stenotic pathologies, then discussing the challenges holding back these innovations. <i>Materials and Methods</i>: A targeted non-systematic review of published literature relating to tracheal reconstruction was performed within the PubMed database to help identify how synthetic materials are utilised to innovate tracheal reconstruction. <i>Results</i>: The advancements in 3D printing to aid synthetic material fabrication have unveiled promising alternatives to conventional approaches. Achieving successful tracheal reconstruction through this technology demands that the 3D models exhibit biocompatibility with neighbouring tracheal elements by encompassing vasculature, chondral foundation, and immunocompatibility. Tracheal reconstruction has employed grafts and scaffolds, showing a promising beginning in vivo. Concurrently, the integration of resorbable models and stem cell therapy serves to underscore their viability and application in the context of tracheal pathologies. Despite this, certain barriers hinder its advancement in surgery. The intricate tracheal structure has posed a challenge for researchers seeking novel approaches to support its growth and regeneration. <i>Conclusions</i>: The potential of synthetic material fabrication has shown promising outcomes in initial studies involving smaller animals. Yet, to fully realise the applicability of these innovative developments, research must progress toward clinical trials. These trials would ascertain the anatomical and physiological effects on the human body, enabling a thorough evaluation of post-operative outcomes and any potential complications linked to the materials or cells implanted in the trachea.https://www.mdpi.com/1648-9144/60/1/40tracheal reconstruction3D printingtissue engineering |
| spellingShingle | Usman Khalid Petar Uchikov Bozhidar Hristov Krasimir Kraev Maria Koleva-Ivanova Maria Kraeva Atanas Batashki Daniela Taneva Mladen Doykov Angel Uchikov Surgical Innovations in Tracheal Reconstruction: A Review on Synthetic Material Fabrication Medicina tracheal reconstruction 3D printing tissue engineering |
| title | Surgical Innovations in Tracheal Reconstruction: A Review on Synthetic Material Fabrication |
| title_full | Surgical Innovations in Tracheal Reconstruction: A Review on Synthetic Material Fabrication |
| title_fullStr | Surgical Innovations in Tracheal Reconstruction: A Review on Synthetic Material Fabrication |
| title_full_unstemmed | Surgical Innovations in Tracheal Reconstruction: A Review on Synthetic Material Fabrication |
| title_short | Surgical Innovations in Tracheal Reconstruction: A Review on Synthetic Material Fabrication |
| title_sort | surgical innovations in tracheal reconstruction a review on synthetic material fabrication |
| topic | tracheal reconstruction 3D printing tissue engineering |
| url | https://www.mdpi.com/1648-9144/60/1/40 |
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