Pincer Complexes Derived from Tridentate Schiff Bases for Their Use as Antimicrobial Metallopharmaceuticals
Within the current challenges in medicinal chemistry, the development of new and better therapeutic agents effective against infectious diseases produced by bacteria, fungi, viruses, and parasites stands out. With chemotherapy as one of the main strategies against these diseases focusing on the admi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Inorganics |
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| Online Access: | https://www.mdpi.com/2304-6740/10/9/134 |
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| author | Alberto Aragón-Muriel Viviana Reyes-Márquez Farrah Cañavera-Buelvas Jesús R. Parra-Unda Fernando Cuenú-Cabezas Dorian Polo-Cerón Raúl Colorado-Peralta Galdina V. Suárez-Moreno Bethsy Adriana Aguilar-Castillo David Morales-Morales |
| author_facet | Alberto Aragón-Muriel Viviana Reyes-Márquez Farrah Cañavera-Buelvas Jesús R. Parra-Unda Fernando Cuenú-Cabezas Dorian Polo-Cerón Raúl Colorado-Peralta Galdina V. Suárez-Moreno Bethsy Adriana Aguilar-Castillo David Morales-Morales |
| author_sort | Alberto Aragón-Muriel |
| collection | DOAJ |
| description | Within the current challenges in medicinal chemistry, the development of new and better therapeutic agents effective against infectious diseases produced by bacteria, fungi, viruses, and parasites stands out. With chemotherapy as one of the main strategies against these diseases focusing on the administration of organic and inorganic drugs, the latter is generally based on the synergistic effect produced by the formation of metal complexes with biologically active organic compounds. In this sense, Schiff bases (SBs) represent and ideal ligand scaffold since they have demonstrated a broad spectrum of antitumor, antiviral, antimicrobial, and anti-inflammatory activities, among others. In addition, SBs are synthesized in an easy manner from one-step condensation reactions, being thus suitable for facile structural modifications, having the imine group as a coordination point found in most of their metal complexes, and promoting chelation when other donor atoms are three, four, or five bonds apart. However, despite the wide variety of metal complexes found in the literature using this type of ligands, only a handful of them include on their structures tridentate SBs ligands and their biological evaluation has been explored. Hence, this review summarizes the most important antimicrobial activity results reported this far for pincer-type complexes (main group and d-block) derived from SBs tridentate ligands. |
| first_indexed | 2024-03-09T23:39:38Z |
| format | Article |
| id | doaj.art-1a633b102edb40748963414275926183 |
| institution | Directory Open Access Journal |
| issn | 2304-6740 |
| language | English |
| last_indexed | 2024-03-09T23:39:38Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj.art-1a633b102edb407489634142759261832023-11-23T16:54:04ZengMDPI AGInorganics2304-67402022-09-0110913410.3390/inorganics10090134Pincer Complexes Derived from Tridentate Schiff Bases for Their Use as Antimicrobial MetallopharmaceuticalsAlberto Aragón-Muriel0Viviana Reyes-Márquez1Farrah Cañavera-Buelvas2Jesús R. Parra-Unda3Fernando Cuenú-Cabezas4Dorian Polo-Cerón5Raúl Colorado-Peralta6Galdina V. Suárez-Moreno7Bethsy Adriana Aguilar-Castillo8David Morales-Morales9Laboratorio de Investigación en Catálisis y Procesos (LICAP), Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad del Valle, Cali 760001, ColombiaDepartamento de Ciencias Químico-Biológicas, Universidad de Sonora, Luis Encinas y Rosales S/N, Hermosillo 83000, MexicoGrupo de Investigación Ciencias, Educación y Tecnología (CETIC), Departamento de Química, Universidad del Atlántico, Puerto Colombia 081001, ColombiaUnidad de Investigaciones en Salud Pública “Dra. Kaethe Willms”, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán 80010, MexicoLaboratory of Inorganic Chemistry and Catalysis, Chemistry Program, Universidad del Quindío, Armenia 630004, ColombiaLaboratorio de Investigación en Catálisis y Procesos (LICAP), Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad del Valle, Cali 760001, ColombiaFacultad de Ciencias Químicas, Universidad Veracruzana, Prolongación de Oriente 6 #1009, Col. Rafael Alvarado, Orizaba 94340, MexicoUnidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Av. Acueducto S/N, Ciudad de México 07340, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Circuito Exterior, Coyoacán, Ciudad de México 04510, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Circuito Exterior, Coyoacán, Ciudad de México 04510, MexicoWithin the current challenges in medicinal chemistry, the development of new and better therapeutic agents effective against infectious diseases produced by bacteria, fungi, viruses, and parasites stands out. With chemotherapy as one of the main strategies against these diseases focusing on the administration of organic and inorganic drugs, the latter is generally based on the synergistic effect produced by the formation of metal complexes with biologically active organic compounds. In this sense, Schiff bases (SBs) represent and ideal ligand scaffold since they have demonstrated a broad spectrum of antitumor, antiviral, antimicrobial, and anti-inflammatory activities, among others. In addition, SBs are synthesized in an easy manner from one-step condensation reactions, being thus suitable for facile structural modifications, having the imine group as a coordination point found in most of their metal complexes, and promoting chelation when other donor atoms are three, four, or five bonds apart. However, despite the wide variety of metal complexes found in the literature using this type of ligands, only a handful of them include on their structures tridentate SBs ligands and their biological evaluation has been explored. Hence, this review summarizes the most important antimicrobial activity results reported this far for pincer-type complexes (main group and d-block) derived from SBs tridentate ligands.https://www.mdpi.com/2304-6740/10/9/134metallopharmaceuticalsSchiff basestridentate ligandspincer ligandsantimicrobial activitymetal-based drugs |
| spellingShingle | Alberto Aragón-Muriel Viviana Reyes-Márquez Farrah Cañavera-Buelvas Jesús R. Parra-Unda Fernando Cuenú-Cabezas Dorian Polo-Cerón Raúl Colorado-Peralta Galdina V. Suárez-Moreno Bethsy Adriana Aguilar-Castillo David Morales-Morales Pincer Complexes Derived from Tridentate Schiff Bases for Their Use as Antimicrobial Metallopharmaceuticals Inorganics metallopharmaceuticals Schiff bases tridentate ligands pincer ligands antimicrobial activity metal-based drugs |
| title | Pincer Complexes Derived from Tridentate Schiff Bases for Their Use as Antimicrobial Metallopharmaceuticals |
| title_full | Pincer Complexes Derived from Tridentate Schiff Bases for Their Use as Antimicrobial Metallopharmaceuticals |
| title_fullStr | Pincer Complexes Derived from Tridentate Schiff Bases for Their Use as Antimicrobial Metallopharmaceuticals |
| title_full_unstemmed | Pincer Complexes Derived from Tridentate Schiff Bases for Their Use as Antimicrobial Metallopharmaceuticals |
| title_short | Pincer Complexes Derived from Tridentate Schiff Bases for Their Use as Antimicrobial Metallopharmaceuticals |
| title_sort | pincer complexes derived from tridentate schiff bases for their use as antimicrobial metallopharmaceuticals |
| topic | metallopharmaceuticals Schiff bases tridentate ligands pincer ligands antimicrobial activity metal-based drugs |
| url | https://www.mdpi.com/2304-6740/10/9/134 |
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