Altered Pharmacokinetics of Daunorubicin in Rats with CCl4-Induced Hepatic Injury

PURPOSE. The effect of CCl4-induced experimental hepatic injury (CCl4-EHI) on the pharmacokinetics of daunorubicin was investigated systemically in rats, in an attempt to elucidate the major determinants of the effect of CCl4-EHI on the pharmacokinetics of the drug. METHODS. CCl4-EHI was induced in...

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Bibliographic Details
Main Authors: Min-Koo Choi, Im-Sook Song, Dae-Duk Kim, Suk-Jae Chung, Chang-Koo Shim
Format: Article
Language:English
Published: Frontiers Media S.A. 2007-09-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/696