Chemotherapy versus support cancer treatment in advanced gastric cancer: a meta-analysis
The aim of the present study was to compare the efficacy of chemotherapy and support treatment in patients with advanced non-resectable gastric cancer in a systematic review and meta-analysis of randomized clinical trials that included a comparison of chemotherapy and support care treatment in patie...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2006-04-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400002 |
| _version_ | 1811202275407822848 |
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| author | L. Casaretto P.L.R. Sousa J.J. Mari |
| author_facet | L. Casaretto P.L.R. Sousa J.J. Mari |
| author_sort | L. Casaretto |
| collection | DOAJ |
| description | The aim of the present study was to compare the efficacy of chemotherapy and support treatment in patients with advanced non-resectable gastric cancer in a systematic review and meta-analysis of randomized clinical trials that included a comparison of chemotherapy and support care treatment in patients diagnosed with gastric adenocarcinoma, regardless of their age, gender or place of treatment. The search strategy was based on the criteria of the Cochrane Base, using the following key words: 1) randomized clinical trials and antineoplastic combined therapy or gastrointestinal neoplasm, 2) stomach neoplasm and drug therapy, 3) clinical trial and multi-modality therapy, 4) stomach neoplasm and drug therapy or quality of life, 5) double-blind method or clinical trial. The search was carried out using the Cochrane, Medline and Lilacs databases. Five studies fulfilled the inclusion criteria, for a total of 390 participants, 208 (53%) receiving chemotherapy, 182 (47%) receiving support care treatment and 6 losses (1.6%). The 1-year survival rate was 8% for support care and 20% for chemotherapy (RR = 2.14, 95% CI = 1.00-4.57, P = 0.05); 30% of the patients in the chemotherapy group and 12% in the support care group attained a 6-month symptom-free period (RR = 2.33, 95% CI = 1.41-3.87, P < 0.01). Quality of life evaluated after 4 months was significantly better for the chemotherapy patients (34%; RR = 2.07, 95% CI = 1.31-3.28, P < 0.01) with tumor mass reduction (RR = 3.32, 95% CI = 0.77-14.24, P = 0.1). Chemotherapy increased the 1-year survival rate of the patients and provided a longer symptom-free period of 6 months and an improvement in quality of life. |
| first_indexed | 2024-04-12T02:37:23Z |
| format | Article |
| id | doaj.art-1a6617fc98484ddd976a665b2ed81b0f |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-04-12T02:37:23Z |
| publishDate | 2006-04-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-1a6617fc98484ddd976a665b2ed81b0f2022-12-22T03:51:28ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2006-04-0139443144010.1590/S0100-879X2006000400002Chemotherapy versus support cancer treatment in advanced gastric cancer: a meta-analysisL. CasarettoP.L.R. SousaJ.J. MariThe aim of the present study was to compare the efficacy of chemotherapy and support treatment in patients with advanced non-resectable gastric cancer in a systematic review and meta-analysis of randomized clinical trials that included a comparison of chemotherapy and support care treatment in patients diagnosed with gastric adenocarcinoma, regardless of their age, gender or place of treatment. The search strategy was based on the criteria of the Cochrane Base, using the following key words: 1) randomized clinical trials and antineoplastic combined therapy or gastrointestinal neoplasm, 2) stomach neoplasm and drug therapy, 3) clinical trial and multi-modality therapy, 4) stomach neoplasm and drug therapy or quality of life, 5) double-blind method or clinical trial. The search was carried out using the Cochrane, Medline and Lilacs databases. Five studies fulfilled the inclusion criteria, for a total of 390 participants, 208 (53%) receiving chemotherapy, 182 (47%) receiving support care treatment and 6 losses (1.6%). The 1-year survival rate was 8% for support care and 20% for chemotherapy (RR = 2.14, 95% CI = 1.00-4.57, P = 0.05); 30% of the patients in the chemotherapy group and 12% in the support care group attained a 6-month symptom-free period (RR = 2.33, 95% CI = 1.41-3.87, P < 0.01). Quality of life evaluated after 4 months was significantly better for the chemotherapy patients (34%; RR = 2.07, 95% CI = 1.31-3.28, P < 0.01) with tumor mass reduction (RR = 3.32, 95% CI = 0.77-14.24, P = 0.1). Chemotherapy increased the 1-year survival rate of the patients and provided a longer symptom-free period of 6 months and an improvement in quality of life.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400002Gastric cancerSystematic reviewCombined antineoplastic therapyCancer support treatmentMeta-analysisChemotherapy |
| spellingShingle | L. Casaretto P.L.R. Sousa J.J. Mari Chemotherapy versus support cancer treatment in advanced gastric cancer: a meta-analysis Brazilian Journal of Medical and Biological Research Gastric cancer Systematic review Combined antineoplastic therapy Cancer support treatment Meta-analysis Chemotherapy |
| title | Chemotherapy versus support cancer treatment in advanced gastric cancer: a meta-analysis |
| title_full | Chemotherapy versus support cancer treatment in advanced gastric cancer: a meta-analysis |
| title_fullStr | Chemotherapy versus support cancer treatment in advanced gastric cancer: a meta-analysis |
| title_full_unstemmed | Chemotherapy versus support cancer treatment in advanced gastric cancer: a meta-analysis |
| title_short | Chemotherapy versus support cancer treatment in advanced gastric cancer: a meta-analysis |
| title_sort | chemotherapy versus support cancer treatment in advanced gastric cancer a meta analysis |
| topic | Gastric cancer Systematic review Combined antineoplastic therapy Cancer support treatment Meta-analysis Chemotherapy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400002 |
| work_keys_str_mv | AT lcasaretto chemotherapyversussupportcancertreatmentinadvancedgastriccancerametaanalysis AT plrsousa chemotherapyversussupportcancertreatmentinadvancedgastriccancerametaanalysis AT jjmari chemotherapyversussupportcancertreatmentinadvancedgastriccancerametaanalysis |