Management of evidence and conflict of interest in guidelines on early childhood allergy prevention and child nutrition: study protocol of a systematic synthesis of guidelines and explorative network analysis [version 2; peer review: 2 approved]
Background With the rising prevalence of allergic diseases in children, prevention of childhood allergies becomes an important public health issue. Recently, a paradigm shift is taking place in the approach to preventing allergies, and clinical practice guidelines (CPG) and food-based dietary guidel...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2023-12-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/11-1290/v2 |
| _version_ | 1797352818156240896 |
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| author | Corinna Schaefer Eva Maria Bitzer Katharina Sieferle |
| author_facet | Corinna Schaefer Eva Maria Bitzer Katharina Sieferle |
| author_sort | Corinna Schaefer |
| collection | DOAJ |
| description | Background With the rising prevalence of allergic diseases in children, prevention of childhood allergies becomes an important public health issue. Recently, a paradigm shift is taking place in the approach to preventing allergies, and clinical practice guidelines (CPG) and food-based dietary guidelines (FBDG) play an important role in providing practitioners with the latest evidence and reliable guidance. However, concern about the methodological quality of the development of FBDGs and CPGs, including limitations in the systematic reviews, lack of transparency and unmanaged conflicts of interest (COI), reduce the trust in these guidelines. Methods We aim to synthesize the available guidance on early childhood allergy prevention (ECAP) through a systematic search for national and international CPGs and FBDGs concerning ECAP and child nutrition (CN) and to assess the quality of the guidelines and management of COI. Additionally, we will analyse the content and the evidence base of the recommendation statements. We aim to quantify the COI in guideline panellists and explore possible associations between COI and recommendations. Through a social network analysis, we expect to elucidate ties between panellists, researchers, institutions, industry and other sponsors. Guidelines are an important tool to inform healthcare practitioners with the newest evidence, but quality and reliability have to be high. This study will help identify potential for further improvement in the development of guidelines and the management of COI. If the social network analysis proves feasible and reveals more information on COI in comparison to disclosed COI from the previous analyses, the methodology can be developed further to identify undisclosed COIs in panelists. Ethics and dissemination This research does not require ethical approval because no human subjects are involved. Results will be published in international peer-reviewed open access journals and via presentations at scientific conferences. |
| first_indexed | 2024-03-08T13:21:22Z |
| format | Article |
| id | doaj.art-1a6a7d7cb81e44048807e3f63acf6a60 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-03-08T13:21:22Z |
| publishDate | 2023-12-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-1a6a7d7cb81e44048807e3f63acf6a602024-01-18T01:00:01ZengF1000 Research LtdF1000Research2046-14022023-12-0111160241Management of evidence and conflict of interest in guidelines on early childhood allergy prevention and child nutrition: study protocol of a systematic synthesis of guidelines and explorative network analysis [version 2; peer review: 2 approved]Corinna Schaefer0Eva Maria Bitzer1Katharina Sieferle2https://orcid.org/0000-0002-4300-8382Agency for Quality in Medicine, Berlin, GermanyDepartment of Public Health and Health Education, Pädagogische Hochschule, Freiburg, 79117, GermanyDepartment of Public Health and Health Education, Pädagogische Hochschule, Freiburg, 79117, GermanyBackground With the rising prevalence of allergic diseases in children, prevention of childhood allergies becomes an important public health issue. Recently, a paradigm shift is taking place in the approach to preventing allergies, and clinical practice guidelines (CPG) and food-based dietary guidelines (FBDG) play an important role in providing practitioners with the latest evidence and reliable guidance. However, concern about the methodological quality of the development of FBDGs and CPGs, including limitations in the systematic reviews, lack of transparency and unmanaged conflicts of interest (COI), reduce the trust in these guidelines. Methods We aim to synthesize the available guidance on early childhood allergy prevention (ECAP) through a systematic search for national and international CPGs and FBDGs concerning ECAP and child nutrition (CN) and to assess the quality of the guidelines and management of COI. Additionally, we will analyse the content and the evidence base of the recommendation statements. We aim to quantify the COI in guideline panellists and explore possible associations between COI and recommendations. Through a social network analysis, we expect to elucidate ties between panellists, researchers, institutions, industry and other sponsors. Guidelines are an important tool to inform healthcare practitioners with the newest evidence, but quality and reliability have to be high. This study will help identify potential for further improvement in the development of guidelines and the management of COI. If the social network analysis proves feasible and reveals more information on COI in comparison to disclosed COI from the previous analyses, the methodology can be developed further to identify undisclosed COIs in panelists. Ethics and dissemination This research does not require ethical approval because no human subjects are involved. Results will be published in international peer-reviewed open access journals and via presentations at scientific conferences.https://f1000research.com/articles/11-1290/v2Early childhood allergy prevention clinical practice guideline food-based dietary guideline conflict of interesteng |
| spellingShingle | Corinna Schaefer Eva Maria Bitzer Katharina Sieferle Management of evidence and conflict of interest in guidelines on early childhood allergy prevention and child nutrition: study protocol of a systematic synthesis of guidelines and explorative network analysis [version 2; peer review: 2 approved] F1000Research Early childhood allergy prevention clinical practice guideline food-based dietary guideline conflict of interest eng |
| title | Management of evidence and conflict of interest in guidelines on early childhood allergy prevention and child nutrition: study protocol of a systematic synthesis of guidelines and explorative network analysis [version 2; peer review: 2 approved] |
| title_full | Management of evidence and conflict of interest in guidelines on early childhood allergy prevention and child nutrition: study protocol of a systematic synthesis of guidelines and explorative network analysis [version 2; peer review: 2 approved] |
| title_fullStr | Management of evidence and conflict of interest in guidelines on early childhood allergy prevention and child nutrition: study protocol of a systematic synthesis of guidelines and explorative network analysis [version 2; peer review: 2 approved] |
| title_full_unstemmed | Management of evidence and conflict of interest in guidelines on early childhood allergy prevention and child nutrition: study protocol of a systematic synthesis of guidelines and explorative network analysis [version 2; peer review: 2 approved] |
| title_short | Management of evidence and conflict of interest in guidelines on early childhood allergy prevention and child nutrition: study protocol of a systematic synthesis of guidelines and explorative network analysis [version 2; peer review: 2 approved] |
| title_sort | management of evidence and conflict of interest in guidelines on early childhood allergy prevention and child nutrition study protocol of a systematic synthesis of guidelines and explorative network analysis version 2 peer review 2 approved |
| topic | Early childhood allergy prevention clinical practice guideline food-based dietary guideline conflict of interest eng |
| url | https://f1000research.com/articles/11-1290/v2 |
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