Neurovascular and Neurometabolic Derailment in Aging and Alzheimer’s Disease
The functional and structural integrity of the brain requires local adjustment of blood flow and regulated delivery of metabolic substrates to meet the metabolic demands imposed by neuronal activation. This process – neurovascular coupling – and ensued alterations of glucose and oxygen metabolism -...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-05-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00103/full |
| _version_ | 1819031771393556480 |
|---|---|
| author | Cátia eLourenço Ana eLedo Cândida eDias Rui M Barbosa João eLaranjinha |
| author_facet | Cátia eLourenço Ana eLedo Cândida eDias Rui M Barbosa João eLaranjinha |
| author_sort | Cátia eLourenço |
| collection | DOAJ |
| description | The functional and structural integrity of the brain requires local adjustment of blood flow and regulated delivery of metabolic substrates to meet the metabolic demands imposed by neuronal activation. This process – neurovascular coupling – and ensued alterations of glucose and oxygen metabolism - neurometabolic coupling - are accomplished by concerted communication between neural and vascular cells. Evidence suggests that neuronal-derived nitric oxide (•NO) is a key player in both phenomena. Alterations in the mechanisms underlying the intimate communication between neural cells and vessels ultimately lead to neuronal dysfunction. Both neurovascular and neurometabolic coupling are perturbed during brain aging and in age-related neuropathologies in close association with cognitive decline. However, despite decades of intense investigation, many aspects remain poorly understood, such as the impact of these alterations. In this review, we address neurovascular and neurometabolic derailment in aging and Alzheimer’s disease, discussing its significance in connection with •NO-related pathways. |
| first_indexed | 2024-12-21T06:51:21Z |
| format | Article |
| id | doaj.art-1a6c615213e14682a5a568adf376c34a |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-21T06:51:21Z |
| publishDate | 2015-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-1a6c615213e14682a5a568adf376c34a2022-12-21T19:12:28ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652015-05-01710.3389/fnagi.2015.00103146408Neurovascular and Neurometabolic Derailment in Aging and Alzheimer’s DiseaseCátia eLourenço0Ana eLedo1Cândida eDias2Rui M Barbosa3João eLaranjinha4University of CoimbraUniversity of CoimbraUniversity of CoimbraUniversity of CoimbraUniversity of CoimbraThe functional and structural integrity of the brain requires local adjustment of blood flow and regulated delivery of metabolic substrates to meet the metabolic demands imposed by neuronal activation. This process – neurovascular coupling – and ensued alterations of glucose and oxygen metabolism - neurometabolic coupling - are accomplished by concerted communication between neural and vascular cells. Evidence suggests that neuronal-derived nitric oxide (•NO) is a key player in both phenomena. Alterations in the mechanisms underlying the intimate communication between neural cells and vessels ultimately lead to neuronal dysfunction. Both neurovascular and neurometabolic coupling are perturbed during brain aging and in age-related neuropathologies in close association with cognitive decline. However, despite decades of intense investigation, many aspects remain poorly understood, such as the impact of these alterations. In this review, we address neurovascular and neurometabolic derailment in aging and Alzheimer’s disease, discussing its significance in connection with •NO-related pathways.http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00103/fullAgingNitric Oxideneurovascular couplingneurometabolismAlzheimer ’s disease |
| spellingShingle | Cátia eLourenço Ana eLedo Cândida eDias Rui M Barbosa João eLaranjinha Neurovascular and Neurometabolic Derailment in Aging and Alzheimer’s Disease Frontiers in Aging Neuroscience Aging Nitric Oxide neurovascular coupling neurometabolism Alzheimer ’s disease |
| title | Neurovascular and Neurometabolic Derailment in Aging and Alzheimer’s Disease |
| title_full | Neurovascular and Neurometabolic Derailment in Aging and Alzheimer’s Disease |
| title_fullStr | Neurovascular and Neurometabolic Derailment in Aging and Alzheimer’s Disease |
| title_full_unstemmed | Neurovascular and Neurometabolic Derailment in Aging and Alzheimer’s Disease |
| title_short | Neurovascular and Neurometabolic Derailment in Aging and Alzheimer’s Disease |
| title_sort | neurovascular and neurometabolic derailment in aging and alzheimer s disease |
| topic | Aging Nitric Oxide neurovascular coupling neurometabolism Alzheimer ’s disease |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00103/full |
| work_keys_str_mv | AT catiaelourenco neurovascularandneurometabolicderailmentinagingandalzheimersdisease AT anaeledo neurovascularandneurometabolicderailmentinagingandalzheimersdisease AT candidaedias neurovascularandneurometabolicderailmentinagingandalzheimersdisease AT ruimbarbosa neurovascularandneurometabolicderailmentinagingandalzheimersdisease AT joaoelaranjinha neurovascularandneurometabolicderailmentinagingandalzheimersdisease |