Omeprazole Treatment Failure in Gastroesophageal Reflux Disease and Genetic Variation at the CYP2C Locus

Omeprazole Treatment Failure in Gastroesophageal Reflux Disease and Genetic Variation at the CYP2C Locus

Omeprazole is extensively used to manage gastroesophageal reflux disease (GERD). It is primarily metabolized by CYP2C19. The CYP2C19*17 (rs12248560) allele and the recently described CYP2C:TG haplotype (rs11188059 and rs2860840) are associated with increased enzymatic activity, and may reduce omepra...

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Bibliographic Details
Main Authors: Ping Siu Kee, Simran D. S. Maggo, Martin A. Kennedy, Murray L. Barclay, Allison L. Miller, Klaus Lehnert, Maurice A. Curtis, Richard L. M. Faull, Remai Parker, Paul K. L. Chin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Genetics
Subjects:
GERD
refractory
CYP2C:TG
reflux
omeprazole
CYP2C19
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.869160/full

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