A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/Ionic Liquid Paste Sensor

A new electrochemical platform was suggested for the sensing of the dasatinib (DA) anticancer drug based on paste electrode modification (PE) amplified with Fe<sub>3</sub>O<sub>4</sub>-SWCNTs nanocomposite and 1-hexyl-3-methylimidazolium tetrafluoroborate (mim-BF<sub>4&...

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Bibliographic Details
Main Authors: Ali Moghaddam, Hassan Ali Zamani, Hassan Karimi-Maleh
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Micromachines
Subjects:
Online Access:https://www.mdpi.com/2072-666X/12/4/437
Description
Summary:A new electrochemical platform was suggested for the sensing of the dasatinib (DA) anticancer drug based on paste electrode modification (PE) amplified with Fe<sub>3</sub>O<sub>4</sub>-SWCNTs nanocomposite and 1-hexyl-3-methylimidazolium tetrafluoroborate (mim-BF<sub>4</sub><sup>−</sup>). The new platform showed a linear dynamic range from 0.001–220 µM with a detection limit of 0.7 nM to determine DA at optimal condition. Electrochemical investigation showed that the redox reaction of DA is relative to changing the pH of solution. Moreover, Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/mim-BF<sub>4</sub><sup>−</sup>/PE has improved the oxidation current of DA about 5.58 times which reduced its oxidation potential by about 120 mV at optimal condition. In the final step, Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/mim-BF<sub>4</sub><sup>−</sup>/PE was used as an analytical platform to determine the DA in tablets and a dextrose saline spike sample, and the results showed recovery data 99.58–103.6% which confirm the powerful ability of the sensor as an analytical tool to determine the DA in real samples.
ISSN:2072-666X