A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/Ionic Liquid Paste Sensor
A new electrochemical platform was suggested for the sensing of the dasatinib (DA) anticancer drug based on paste electrode modification (PE) amplified with Fe<sub>3</sub>O<sub>4</sub>-SWCNTs nanocomposite and 1-hexyl-3-methylimidazolium tetrafluoroborate (mim-BF<sub>4&...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/12/4/437 |
| _version_ | 1797537703200292864 |
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| author | Ali Moghaddam Hassan Ali Zamani Hassan Karimi-Maleh |
| author_facet | Ali Moghaddam Hassan Ali Zamani Hassan Karimi-Maleh |
| author_sort | Ali Moghaddam |
| collection | DOAJ |
| description | A new electrochemical platform was suggested for the sensing of the dasatinib (DA) anticancer drug based on paste electrode modification (PE) amplified with Fe<sub>3</sub>O<sub>4</sub>-SWCNTs nanocomposite and 1-hexyl-3-methylimidazolium tetrafluoroborate (mim-BF<sub>4</sub><sup>−</sup>). The new platform showed a linear dynamic range from 0.001–220 µM with a detection limit of 0.7 nM to determine DA at optimal condition. Electrochemical investigation showed that the redox reaction of DA is relative to changing the pH of solution. Moreover, Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/mim-BF<sub>4</sub><sup>−</sup>/PE has improved the oxidation current of DA about 5.58 times which reduced its oxidation potential by about 120 mV at optimal condition. In the final step, Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/mim-BF<sub>4</sub><sup>−</sup>/PE was used as an analytical platform to determine the DA in tablets and a dextrose saline spike sample, and the results showed recovery data 99.58–103.6% which confirm the powerful ability of the sensor as an analytical tool to determine the DA in real samples. |
| first_indexed | 2024-03-10T12:19:12Z |
| format | Article |
| id | doaj.art-1a6ed5a0b43c41209ced64cb645daafa |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T12:19:12Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-1a6ed5a0b43c41209ced64cb645daafa2023-11-21T15:35:25ZengMDPI AGMicromachines2072-666X2021-04-0112443710.3390/mi12040437A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/Ionic Liquid Paste SensorAli Moghaddam0Hassan Ali Zamani1Hassan Karimi-Maleh2Department of Applied Chemistry, Mashhad Branch, Islamic Azad University, Mashhad 9187147578, IranDepartment of Applied Chemistry, Mashhad Branch, Islamic Azad University, Mashhad 9187147578, IranLaboratory of Nanotechnology, Department of Chemical Engineering and Energy, Quchan University of Technology, Quchan 9477177870, IranA new electrochemical platform was suggested for the sensing of the dasatinib (DA) anticancer drug based on paste electrode modification (PE) amplified with Fe<sub>3</sub>O<sub>4</sub>-SWCNTs nanocomposite and 1-hexyl-3-methylimidazolium tetrafluoroborate (mim-BF<sub>4</sub><sup>−</sup>). The new platform showed a linear dynamic range from 0.001–220 µM with a detection limit of 0.7 nM to determine DA at optimal condition. Electrochemical investigation showed that the redox reaction of DA is relative to changing the pH of solution. Moreover, Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/mim-BF<sub>4</sub><sup>−</sup>/PE has improved the oxidation current of DA about 5.58 times which reduced its oxidation potential by about 120 mV at optimal condition. In the final step, Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/mim-BF<sub>4</sub><sup>−</sup>/PE was used as an analytical platform to determine the DA in tablets and a dextrose saline spike sample, and the results showed recovery data 99.58–103.6% which confirm the powerful ability of the sensor as an analytical tool to determine the DA in real samples.https://www.mdpi.com/2072-666X/12/4/437dasatinibFe<sub>3</sub>O<sub>4</sub>-SWCNTs nanocompositeionic liquidsensor |
| spellingShingle | Ali Moghaddam Hassan Ali Zamani Hassan Karimi-Maleh A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/Ionic Liquid Paste Sensor Micromachines dasatinib Fe<sub>3</sub>O<sub>4</sub>-SWCNTs nanocomposite ionic liquid sensor |
| title | A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/Ionic Liquid Paste Sensor |
| title_full | A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/Ionic Liquid Paste Sensor |
| title_fullStr | A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/Ionic Liquid Paste Sensor |
| title_full_unstemmed | A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/Ionic Liquid Paste Sensor |
| title_short | A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe<sub>3</sub>O<sub>4</sub>-SWCNTs/Ionic Liquid Paste Sensor |
| title_sort | new electrochemical platform for dasatinib anticancer drug sensing using fe sub 3 sub o sub 4 sub swcnts ionic liquid paste sensor |
| topic | dasatinib Fe<sub>3</sub>O<sub>4</sub>-SWCNTs nanocomposite ionic liquid sensor |
| url | https://www.mdpi.com/2072-666X/12/4/437 |
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