Four-Week Supplementation of Water-Soluble Tomato Extract Attenuates Platelet Function in Chinese Healthy Middle-Aged and Older Individuals: A Randomized, Double-Blinded, and Crossover Clinical Trial
Background and AimsPlatelets are linked to atherosclerotic development and pathological thrombosis. Single dose of water-soluble tomato extract (WTE) which is a natural extraction can exert anti-platelet effects after 3 or 7 h in British healthy people. However, the effects of WTE supplementation on...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.891241/full |
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| author | Zezhong Tian Zezhong Tian Zezhong Tian Die Fan Kongyao Li Dan Zhao Dan Zhao Dan Zhao Ying Liang Ying Liang Ying Liang Qiuhua Ji Qiuhua Ji Qiuhua Ji Xiaoli Gao Xilin Ma Xilin Ma Xilin Ma Yimin Zhao Yimin Zhao Yimin Zhao Yuheng Mao Yuheng Mao Yuheng Mao Huicui Meng Huicui Meng Huicui Meng Yan Yang Yan Yang Yan Yang |
| author_facet | Zezhong Tian Zezhong Tian Zezhong Tian Die Fan Kongyao Li Dan Zhao Dan Zhao Dan Zhao Ying Liang Ying Liang Ying Liang Qiuhua Ji Qiuhua Ji Qiuhua Ji Xiaoli Gao Xilin Ma Xilin Ma Xilin Ma Yimin Zhao Yimin Zhao Yimin Zhao Yuheng Mao Yuheng Mao Yuheng Mao Huicui Meng Huicui Meng Huicui Meng Yan Yang Yan Yang Yan Yang |
| author_sort | Zezhong Tian |
| collection | DOAJ |
| description | Background and AimsPlatelets are linked to atherosclerotic development and pathological thrombosis. Single dose of water-soluble tomato extract (WTE) which is a natural extraction can exert anti-platelet effects after 3 or 7 h in British healthy people. However, the effects of WTE supplementation on platelet function in Chinese healthy middle-aged and older individuals have not been studied, and the effects or safety of 4-week WTE supplementation also remain unclear. The present study aims to determine the effects of WTE on platelet function, and explore the safety of 4-week WTE supplementation in Chinese healthy middle-aged and older individuals.MethodsA randomized, double-blinded, and crossover clinical trial was conducted. Firstly, 105 individuals were randomly divided into two groups that received WTE (150 mg/day) or placebo for 4 weeks. Then, after a washout period of 2 weeks, two groups exchanged groups and continued for another 4-week intervention. Platelet aggregation, P-selectin, activated GPIIbIIIa, plasma platelet factor 4 (PF4), β-thromboglobulin (β-TG), and thromboxane B2 (TXB2) were tested at baseline, 4, 6, and 10 weeks.ResultsCompared with the placebo group, 150 mg/day WTE supplement for 4 weeks significantly reduced ADP-induced or collagen-induced platelet aggregation (−10.8 ± 1.8 or −3.9 ± 1.5%, P < 0.05), ADP-induced or collagen-induced platelet P-selectin expression (−6.9 ± 1.5 or −6.6 ± 1.3%, P < 0.05), ADP-induced or collagen-induced activated GPIIbIIIa (−6.2 ± 2.0 or −3.8 ± 2.0%, P < 0.05). Besides, 4-week intervention of 150 mg WTE per day also resulted in significant reductions in plasma PF4 (−120.6 ± 33.2 ng/mL, P < 0.05) and β-TG (−129.7 ± 27.5 ng/mL, P < 0.05) and TXB2 (−42.0 ± 4.0 ng/mL, P < 0.05), while had no effects on coagulation function and liver or renal function. Interestingly, 2-week washout period is enough to reverse the inhibitory effect of 4-week WTE supplementation on platelet function.ConclusionWTE supplementation for 4 weeks could moderately reduce platelet activation, aggregation, and granule secretion in Chinese healthy middle-aged and older individuals, and these effects are safe. After 2-week washout period, the inhibitory effect of 4-week WTE on platelet function can be eliminated.Clinical Trial Registration[http://www.chictr.org.cn/], identifier [ChiCTR-POR-17012927]. |
| first_indexed | 2024-04-12T13:06:41Z |
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| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T13:06:41Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-1a6f963f53b849dba7515cac5b3913bc2022-12-22T03:31:59ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-06-01910.3389/fnut.2022.891241891241Four-Week Supplementation of Water-Soluble Tomato Extract Attenuates Platelet Function in Chinese Healthy Middle-Aged and Older Individuals: A Randomized, Double-Blinded, and Crossover Clinical TrialZezhong Tian0Zezhong Tian1Zezhong Tian2Die Fan3Kongyao Li4Dan Zhao5Dan Zhao6Dan Zhao7Ying Liang8Ying Liang9Ying Liang10Qiuhua Ji11Qiuhua Ji12Qiuhua Ji13Xiaoli Gao14Xilin Ma15Xilin Ma16Xilin Ma17Yimin Zhao18Yimin Zhao19Yimin Zhao20Yuheng Mao21Yuheng Mao22Yuheng Mao23Huicui Meng24Huicui Meng25Huicui Meng26Yan Yang27Yan Yang28Yan Yang29School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, ChinaGuangdong Engineering Technology Center of Nutrition Transformation, Guangzhou, ChinaDepartment of Clinical Nutrition, The General Hospital of Western Theater Command, Chengdu, ChinaShenzhen Nanshan Center for Chronic Disease Control, Shenzhen, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, ChinaGuangdong Engineering Technology Center of Nutrition Transformation, Guangzhou, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, ChinaGuangdong Engineering Technology Center of Nutrition Transformation, Guangzhou, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, ChinaGuangdong Engineering Technology Center of Nutrition Transformation, Guangzhou, ChinaThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, ChinaGuangdong Engineering Technology Center of Nutrition Transformation, Guangzhou, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, ChinaGuangdong Engineering Technology Center of Nutrition Transformation, Guangzhou, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, ChinaGuangdong Engineering Technology Center of Nutrition Transformation, Guangzhou, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, ChinaGuangdong Engineering Technology Center of Nutrition Transformation, Guangzhou, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, ChinaGuangdong Engineering Technology Center of Nutrition Transformation, Guangzhou, ChinaBackground and AimsPlatelets are linked to atherosclerotic development and pathological thrombosis. Single dose of water-soluble tomato extract (WTE) which is a natural extraction can exert anti-platelet effects after 3 or 7 h in British healthy people. However, the effects of WTE supplementation on platelet function in Chinese healthy middle-aged and older individuals have not been studied, and the effects or safety of 4-week WTE supplementation also remain unclear. The present study aims to determine the effects of WTE on platelet function, and explore the safety of 4-week WTE supplementation in Chinese healthy middle-aged and older individuals.MethodsA randomized, double-blinded, and crossover clinical trial was conducted. Firstly, 105 individuals were randomly divided into two groups that received WTE (150 mg/day) or placebo for 4 weeks. Then, after a washout period of 2 weeks, two groups exchanged groups and continued for another 4-week intervention. Platelet aggregation, P-selectin, activated GPIIbIIIa, plasma platelet factor 4 (PF4), β-thromboglobulin (β-TG), and thromboxane B2 (TXB2) were tested at baseline, 4, 6, and 10 weeks.ResultsCompared with the placebo group, 150 mg/day WTE supplement for 4 weeks significantly reduced ADP-induced or collagen-induced platelet aggregation (−10.8 ± 1.8 or −3.9 ± 1.5%, P < 0.05), ADP-induced or collagen-induced platelet P-selectin expression (−6.9 ± 1.5 or −6.6 ± 1.3%, P < 0.05), ADP-induced or collagen-induced activated GPIIbIIIa (−6.2 ± 2.0 or −3.8 ± 2.0%, P < 0.05). Besides, 4-week intervention of 150 mg WTE per day also resulted in significant reductions in plasma PF4 (−120.6 ± 33.2 ng/mL, P < 0.05) and β-TG (−129.7 ± 27.5 ng/mL, P < 0.05) and TXB2 (−42.0 ± 4.0 ng/mL, P < 0.05), while had no effects on coagulation function and liver or renal function. Interestingly, 2-week washout period is enough to reverse the inhibitory effect of 4-week WTE supplementation on platelet function.ConclusionWTE supplementation for 4 weeks could moderately reduce platelet activation, aggregation, and granule secretion in Chinese healthy middle-aged and older individuals, and these effects are safe. After 2-week washout period, the inhibitory effect of 4-week WTE on platelet function can be eliminated.Clinical Trial Registration[http://www.chictr.org.cn/], identifier [ChiCTR-POR-17012927].https://www.frontiersin.org/articles/10.3389/fnut.2022.891241/fullwater-soluble tomato extractrandomized clinical trialplateletChinese healthy middle-aged and older individualscrossover study |
| spellingShingle | Zezhong Tian Zezhong Tian Zezhong Tian Die Fan Kongyao Li Dan Zhao Dan Zhao Dan Zhao Ying Liang Ying Liang Ying Liang Qiuhua Ji Qiuhua Ji Qiuhua Ji Xiaoli Gao Xilin Ma Xilin Ma Xilin Ma Yimin Zhao Yimin Zhao Yimin Zhao Yuheng Mao Yuheng Mao Yuheng Mao Huicui Meng Huicui Meng Huicui Meng Yan Yang Yan Yang Yan Yang Four-Week Supplementation of Water-Soluble Tomato Extract Attenuates Platelet Function in Chinese Healthy Middle-Aged and Older Individuals: A Randomized, Double-Blinded, and Crossover Clinical Trial Frontiers in Nutrition water-soluble tomato extract randomized clinical trial platelet Chinese healthy middle-aged and older individuals crossover study |
| title | Four-Week Supplementation of Water-Soluble Tomato Extract Attenuates Platelet Function in Chinese Healthy Middle-Aged and Older Individuals: A Randomized, Double-Blinded, and Crossover Clinical Trial |
| title_full | Four-Week Supplementation of Water-Soluble Tomato Extract Attenuates Platelet Function in Chinese Healthy Middle-Aged and Older Individuals: A Randomized, Double-Blinded, and Crossover Clinical Trial |
| title_fullStr | Four-Week Supplementation of Water-Soluble Tomato Extract Attenuates Platelet Function in Chinese Healthy Middle-Aged and Older Individuals: A Randomized, Double-Blinded, and Crossover Clinical Trial |
| title_full_unstemmed | Four-Week Supplementation of Water-Soluble Tomato Extract Attenuates Platelet Function in Chinese Healthy Middle-Aged and Older Individuals: A Randomized, Double-Blinded, and Crossover Clinical Trial |
| title_short | Four-Week Supplementation of Water-Soluble Tomato Extract Attenuates Platelet Function in Chinese Healthy Middle-Aged and Older Individuals: A Randomized, Double-Blinded, and Crossover Clinical Trial |
| title_sort | four week supplementation of water soluble tomato extract attenuates platelet function in chinese healthy middle aged and older individuals a randomized double blinded and crossover clinical trial |
| topic | water-soluble tomato extract randomized clinical trial platelet Chinese healthy middle-aged and older individuals crossover study |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.891241/full |
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