Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogaster
The eye of the fruit fly Drosophila melanogaster provides a highly tractable genetic model system for the study of animal development, and many genes that regulate Drosophila eye formation have homologs implicated in human development and disease. Among these is the homeobox gene sine oculis (so), w...
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| Format: | Article |
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Elsevier
2014-12-01
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| Series: | Genomics Data |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221359601400049X |
| _version_ | 1818537967522676736 |
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| author | Barbara Jusiak Feng Wang Umesh C. Karandikar Su-Jin Kwak Hui Wang Rui Chen Graeme Mardon |
| author_facet | Barbara Jusiak Feng Wang Umesh C. Karandikar Su-Jin Kwak Hui Wang Rui Chen Graeme Mardon |
| author_sort | Barbara Jusiak |
| collection | DOAJ |
| description | The eye of the fruit fly Drosophila melanogaster provides a highly tractable genetic model system for the study of animal development, and many genes that regulate Drosophila eye formation have homologs implicated in human development and disease. Among these is the homeobox gene sine oculis (so), which encodes a homeodomain transcription factor (TF) that is both necessary for eye development and sufficient to reprogram a subset of cells outside the normal eye field toward an eye fate. We have performed a genome-wide analysis of So binding to DNA prepared from developing Drosophila eye tissue in order to identify candidate direct targets of So-mediated transcriptional regulation, as described in our recent article [20]. The data are available from NCBI Gene Expression Omnibus (GEO) with the accession number GSE52943. Here we describe the methods, data analysis, and quality control of our So ChIP-seq dataset. |
| first_indexed | 2024-12-11T18:57:32Z |
| format | Article |
| id | doaj.art-1a70ee9cd6b34d818c18d2e2754c9d9c |
| institution | Directory Open Access Journal |
| issn | 2213-5960 |
| language | English |
| last_indexed | 2024-12-11T18:57:32Z |
| publishDate | 2014-12-01 |
| publisher | Elsevier |
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| series | Genomics Data |
| spelling | doaj.art-1a70ee9cd6b34d818c18d2e2754c9d9c2022-12-22T00:54:06ZengElsevierGenomics Data2213-59602014-12-012C15315510.1016/j.gdata.2014.06.016Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogasterBarbara Jusiak0Feng Wang1Umesh C. Karandikar2Su-Jin Kwak3Hui Wang4Rui Chen5Graeme Mardon6Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USADepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USADepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USADepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USADepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USAProgram in Developmental Biology, Baylor College of Medicine, Houston, TX, USAProgram in Developmental Biology, Baylor College of Medicine, Houston, TX, USAThe eye of the fruit fly Drosophila melanogaster provides a highly tractable genetic model system for the study of animal development, and many genes that regulate Drosophila eye formation have homologs implicated in human development and disease. Among these is the homeobox gene sine oculis (so), which encodes a homeodomain transcription factor (TF) that is both necessary for eye development and sufficient to reprogram a subset of cells outside the normal eye field toward an eye fate. We have performed a genome-wide analysis of So binding to DNA prepared from developing Drosophila eye tissue in order to identify candidate direct targets of So-mediated transcriptional regulation, as described in our recent article [20]. The data are available from NCBI Gene Expression Omnibus (GEO) with the accession number GSE52943. Here we describe the methods, data analysis, and quality control of our So ChIP-seq dataset.http://www.sciencedirect.com/science/article/pii/S221359601400049XSine oculisChIP-seqDrosophilaEyeDevelopment |
| spellingShingle | Barbara Jusiak Feng Wang Umesh C. Karandikar Su-Jin Kwak Hui Wang Rui Chen Graeme Mardon Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogaster Genomics Data Sine oculis ChIP-seq Drosophila Eye Development |
| title | Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogaster |
| title_full | Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogaster |
| title_fullStr | Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogaster |
| title_full_unstemmed | Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogaster |
| title_short | Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogaster |
| title_sort | genome wide dna binding pattern of the homeodomain transcription factor sine oculis so in the developing eye of drosophila melanogaster |
| topic | Sine oculis ChIP-seq Drosophila Eye Development |
| url | http://www.sciencedirect.com/science/article/pii/S221359601400049X |
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