Interaction between <i>Akkermansia muciniphila</i> and Diet Is Associated with Proinflammatory Index in School-Aged Children
Background: Imbalance in the intestinal microbiota can lead to chronic low-grade inflammation. Diet may influence this association. In this study, we aimed to evaluate the interaction between <i>Akkermansia muciniphila</i> (<i>A. muciniphila</i>) and dietary patterns using a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/11/1799 |
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| author | Juan Carlos Ayala-García Alba Mariel García-Vera Alfredo Lagunas-Martínez Yaneth Citlalli Orbe-Orihuela Ana Cristina Castañeda-Márquez Cinthya Estefhany Díaz-Benítez Víctor Hugo Bermúdez-Morales Miguel Cruz Margarita Bahena-Román Ana Isabel Burguete-García |
| author_facet | Juan Carlos Ayala-García Alba Mariel García-Vera Alfredo Lagunas-Martínez Yaneth Citlalli Orbe-Orihuela Ana Cristina Castañeda-Márquez Cinthya Estefhany Díaz-Benítez Víctor Hugo Bermúdez-Morales Miguel Cruz Margarita Bahena-Román Ana Isabel Burguete-García |
| author_sort | Juan Carlos Ayala-García |
| collection | DOAJ |
| description | Background: Imbalance in the intestinal microbiota can lead to chronic low-grade inflammation. Diet may influence this association. In this study, we aimed to evaluate the interaction between <i>Akkermansia muciniphila</i> (<i>A. muciniphila</i>) and dietary patterns using a proinflammatory index. Methods: We conducted a cross-sectional study with school-aged children. We quantified the relative abundance (RA) of <i>A. muciniphila</i> in feces using a polymerase chain reaction. We collected dietary information through employing a food frequency questionnaire and generated dietary patterns using principal component analysis. We generated a proinflammatory index from serum levels of interleukin-6, interleukin-10, tumor necrosis factor alpha, and adiponectin validated by receptor operating characteristic curves. We evaluated the association between <i>A. muciniphila</i> and the proinflammatory index using logistic regression, including an interaction term with dietary patterns. Results: We found that children with a low RA of <i>A. muciniphila</i> and a high intake of simple carbohydrates and saturated fats had increased odds of being high on the proinflammatory index. However, when the consumption of this dietary pattern is low, children with a low RA of <i>A. muciniphila</i> had decreased odds of being high on the proinflammatory index. Conclusions: Our results suggest that the simultaneous presence of <i>A. muciniphila</i> and diet have a more significant impact on the presence of being high on the proinflammatory index compared to both factors separately. |
| first_indexed | 2024-03-09T16:55:25Z |
| format | Article |
| id | doaj.art-1a726f6f118f41cb970720a6eab91d94 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T16:55:25Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-1a726f6f118f41cb970720a6eab91d942023-11-24T14:35:56ZengMDPI AGChildren2227-90672023-11-011011179910.3390/children10111799Interaction between <i>Akkermansia muciniphila</i> and Diet Is Associated with Proinflammatory Index in School-Aged ChildrenJuan Carlos Ayala-García0Alba Mariel García-Vera1Alfredo Lagunas-Martínez2Yaneth Citlalli Orbe-Orihuela3Ana Cristina Castañeda-Márquez4Cinthya Estefhany Díaz-Benítez5Víctor Hugo Bermúdez-Morales6Miguel Cruz7Margarita Bahena-Román8Ana Isabel Burguete-García9Centro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca 62100, MexicoEscuela de Salud Pública de México, Instituto Nacional de Salud Pública, Cuernavaca 62100, MexicoCentro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca 62100, MexicoCentro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca 62100, MexicoInstituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango 34100, MexicoCentro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca 62100, MexicoCentro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca 62100, MexicoUnidad de Investigación Médica en Bioquímica, Centro Médico Nacional Siglo XXI, Ciudad de México 06720, MexicoCentro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca 62100, MexicoCentro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca 62100, MexicoBackground: Imbalance in the intestinal microbiota can lead to chronic low-grade inflammation. Diet may influence this association. In this study, we aimed to evaluate the interaction between <i>Akkermansia muciniphila</i> (<i>A. muciniphila</i>) and dietary patterns using a proinflammatory index. Methods: We conducted a cross-sectional study with school-aged children. We quantified the relative abundance (RA) of <i>A. muciniphila</i> in feces using a polymerase chain reaction. We collected dietary information through employing a food frequency questionnaire and generated dietary patterns using principal component analysis. We generated a proinflammatory index from serum levels of interleukin-6, interleukin-10, tumor necrosis factor alpha, and adiponectin validated by receptor operating characteristic curves. We evaluated the association between <i>A. muciniphila</i> and the proinflammatory index using logistic regression, including an interaction term with dietary patterns. Results: We found that children with a low RA of <i>A. muciniphila</i> and a high intake of simple carbohydrates and saturated fats had increased odds of being high on the proinflammatory index. However, when the consumption of this dietary pattern is low, children with a low RA of <i>A. muciniphila</i> had decreased odds of being high on the proinflammatory index. Conclusions: Our results suggest that the simultaneous presence of <i>A. muciniphila</i> and diet have a more significant impact on the presence of being high on the proinflammatory index compared to both factors separately.https://www.mdpi.com/2227-9067/10/11/1799gut microbiotadietary patternscytokinesinflammation |
| spellingShingle | Juan Carlos Ayala-García Alba Mariel García-Vera Alfredo Lagunas-Martínez Yaneth Citlalli Orbe-Orihuela Ana Cristina Castañeda-Márquez Cinthya Estefhany Díaz-Benítez Víctor Hugo Bermúdez-Morales Miguel Cruz Margarita Bahena-Román Ana Isabel Burguete-García Interaction between <i>Akkermansia muciniphila</i> and Diet Is Associated with Proinflammatory Index in School-Aged Children Children gut microbiota dietary patterns cytokines inflammation |
| title | Interaction between <i>Akkermansia muciniphila</i> and Diet Is Associated with Proinflammatory Index in School-Aged Children |
| title_full | Interaction between <i>Akkermansia muciniphila</i> and Diet Is Associated with Proinflammatory Index in School-Aged Children |
| title_fullStr | Interaction between <i>Akkermansia muciniphila</i> and Diet Is Associated with Proinflammatory Index in School-Aged Children |
| title_full_unstemmed | Interaction between <i>Akkermansia muciniphila</i> and Diet Is Associated with Proinflammatory Index in School-Aged Children |
| title_short | Interaction between <i>Akkermansia muciniphila</i> and Diet Is Associated with Proinflammatory Index in School-Aged Children |
| title_sort | interaction between i akkermansia muciniphila i and diet is associated with proinflammatory index in school aged children |
| topic | gut microbiota dietary patterns cytokines inflammation |
| url | https://www.mdpi.com/2227-9067/10/11/1799 |
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