3D Genome Organization: Causes and Consequences for DNA Damage and Repair
The inability to repair damaged DNA severely compromises the integrity of any organism. In eukaryotes, the DNA damage response (DDR) operates within chromatin, a tightly organized DNA–histone complex in a non-random manner within the nucleus. Chromatin thus orchestrates various cellular processes, i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/1/7 |
| _version_ | 1797493825602584576 |
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| author | Ànnia Carré-Simon Emmanuelle Fabre |
| author_facet | Ànnia Carré-Simon Emmanuelle Fabre |
| author_sort | Ànnia Carré-Simon |
| collection | DOAJ |
| description | The inability to repair damaged DNA severely compromises the integrity of any organism. In eukaryotes, the DNA damage response (DDR) operates within chromatin, a tightly organized DNA–histone complex in a non-random manner within the nucleus. Chromatin thus orchestrates various cellular processes, including repair. Here, we examine the chromatin landscape before, during, and after the DNA damage, focusing on double strand breaks (DSBs). We study how chromatin is modified during the repair process, not only around the damaged region (in <i>cis</i>), but also genome-wide (in <i>trans</i>). Recent evidence has highlighted a complex landscape in which different chromatin parameters (stiffness, compaction, loops) are transiently modified, defining “codes” for each specific stage of the DDR. We illustrate a novel aspect of DDR where chromatin modifications contribute to the movement of DSB-damaged chromatin, as well as undamaged chromatin, ensuring the mobilization of DSBs, their clustering, and their repair processes. |
| first_indexed | 2024-03-10T01:25:31Z |
| format | Article |
| id | doaj.art-1a72f5ecd2324984be78ac9a9c9df3cf |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T01:25:31Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-1a72f5ecd2324984be78ac9a9c9df3cf2023-11-23T13:50:48ZengMDPI AGGenes2073-44252021-12-01131710.3390/genes130100073D Genome Organization: Causes and Consequences for DNA Damage and RepairÀnnia Carré-Simon0Emmanuelle Fabre1Université de Paris, CNRS UMR7212, INSERM U944, Génomes Biologie Cellulaire et Thérapeutiques, F-75010 Paris, FranceUniversité de Paris, CNRS UMR7212, INSERM U944, Génomes Biologie Cellulaire et Thérapeutiques, F-75010 Paris, FranceThe inability to repair damaged DNA severely compromises the integrity of any organism. In eukaryotes, the DNA damage response (DDR) operates within chromatin, a tightly organized DNA–histone complex in a non-random manner within the nucleus. Chromatin thus orchestrates various cellular processes, including repair. Here, we examine the chromatin landscape before, during, and after the DNA damage, focusing on double strand breaks (DSBs). We study how chromatin is modified during the repair process, not only around the damaged region (in <i>cis</i>), but also genome-wide (in <i>trans</i>). Recent evidence has highlighted a complex landscape in which different chromatin parameters (stiffness, compaction, loops) are transiently modified, defining “codes” for each specific stage of the DDR. We illustrate a novel aspect of DDR where chromatin modifications contribute to the movement of DSB-damaged chromatin, as well as undamaged chromatin, ensuring the mobilization of DSBs, their clustering, and their repair processes.https://www.mdpi.com/2073-4425/13/1/7chromosome organizationdouble strand breakchromatin dynamics |
| spellingShingle | Ànnia Carré-Simon Emmanuelle Fabre 3D Genome Organization: Causes and Consequences for DNA Damage and Repair Genes chromosome organization double strand break chromatin dynamics |
| title | 3D Genome Organization: Causes and Consequences for DNA Damage and Repair |
| title_full | 3D Genome Organization: Causes and Consequences for DNA Damage and Repair |
| title_fullStr | 3D Genome Organization: Causes and Consequences for DNA Damage and Repair |
| title_full_unstemmed | 3D Genome Organization: Causes and Consequences for DNA Damage and Repair |
| title_short | 3D Genome Organization: Causes and Consequences for DNA Damage and Repair |
| title_sort | 3d genome organization causes and consequences for dna damage and repair |
| topic | chromosome organization double strand break chromatin dynamics |
| url | https://www.mdpi.com/2073-4425/13/1/7 |
| work_keys_str_mv | AT anniacarresimon 3dgenomeorganizationcausesandconsequencesfordnadamageandrepair AT emmanuellefabre 3dgenomeorganizationcausesandconsequencesfordnadamageandrepair |