Simulated Obstructive Sleep Apnea Increases P-Wave Duration and P-Wave Dispersion.
BACKGROUND:A high P-wave duration and dispersion (Pd) have been reported to be a prognostic factor for the occurrence of paroxysmal atrial fibrillation (PAF), a condition linked to obstructive sleep apnea (OSA). We tested the hypothesis of whether a short-term increase of P-wave duration and Pd can...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4829247?pdf=render |
| _version_ | 1819204029432987648 |
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| author | Thomas Gaisl Annette M Wons Valentina Rossi Daniel J Bratton Christian Schlatzer Esther I Schwarz Giovanni Camen Malcolm Kohler |
| author_facet | Thomas Gaisl Annette M Wons Valentina Rossi Daniel J Bratton Christian Schlatzer Esther I Schwarz Giovanni Camen Malcolm Kohler |
| author_sort | Thomas Gaisl |
| collection | DOAJ |
| description | BACKGROUND:A high P-wave duration and dispersion (Pd) have been reported to be a prognostic factor for the occurrence of paroxysmal atrial fibrillation (PAF), a condition linked to obstructive sleep apnea (OSA). We tested the hypothesis of whether a short-term increase of P-wave duration and Pd can be induced by respiratory manoeuvres simulating OSA in healthy subjects and in patients with PAF. METHODS:12-lead-electrocardiography (ECG) was recorded continuously in 24 healthy subjects and 33 patients with PAF, while simulating obstructive apnea (Mueller manoeuvre, MM), obstructive hypopnea (inspiration through a threshold load, ITH), central apnea (AP), and during normal breathing (BL) in randomized order. The P-wave duration and Pd was calculated by using dedicated software for ECG-analysis. RESULTS:P-wave duration and Pd significantly increased during MM and ITH compared to BL in all subjects (+13.1 ms and +13.8 ms during MM; +11.7 ms and +12.9 ms during ITH; p<0.001 for all comparisons). In MM, the increase was larger in healthy subjects when compared to patients with PAF (p<0.05). CONCLUSION:Intrathoracic pressure swings through simulated obstructive sleep apnea increase P-wave duration and Pd in healthy subjects and in patients with PAF. Our findings imply that intrathoracic pressure swings prolong the intra-atrial and inter-atrial conduction time and therefore may represent an independent trigger factor for the development for PAF. |
| first_indexed | 2024-12-23T04:29:19Z |
| format | Article |
| id | doaj.art-1a742c02be8c4ec193104a97f930ab4c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T04:29:19Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1a742c02be8c4ec193104a97f930ab4c2022-12-21T18:00:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01114e015299410.1371/journal.pone.0152994Simulated Obstructive Sleep Apnea Increases P-Wave Duration and P-Wave Dispersion.Thomas GaislAnnette M WonsValentina RossiDaniel J BrattonChristian SchlatzerEsther I SchwarzGiovanni CamenMalcolm KohlerBACKGROUND:A high P-wave duration and dispersion (Pd) have been reported to be a prognostic factor for the occurrence of paroxysmal atrial fibrillation (PAF), a condition linked to obstructive sleep apnea (OSA). We tested the hypothesis of whether a short-term increase of P-wave duration and Pd can be induced by respiratory manoeuvres simulating OSA in healthy subjects and in patients with PAF. METHODS:12-lead-electrocardiography (ECG) was recorded continuously in 24 healthy subjects and 33 patients with PAF, while simulating obstructive apnea (Mueller manoeuvre, MM), obstructive hypopnea (inspiration through a threshold load, ITH), central apnea (AP), and during normal breathing (BL) in randomized order. The P-wave duration and Pd was calculated by using dedicated software for ECG-analysis. RESULTS:P-wave duration and Pd significantly increased during MM and ITH compared to BL in all subjects (+13.1 ms and +13.8 ms during MM; +11.7 ms and +12.9 ms during ITH; p<0.001 for all comparisons). In MM, the increase was larger in healthy subjects when compared to patients with PAF (p<0.05). CONCLUSION:Intrathoracic pressure swings through simulated obstructive sleep apnea increase P-wave duration and Pd in healthy subjects and in patients with PAF. Our findings imply that intrathoracic pressure swings prolong the intra-atrial and inter-atrial conduction time and therefore may represent an independent trigger factor for the development for PAF.http://europepmc.org/articles/PMC4829247?pdf=render |
| spellingShingle | Thomas Gaisl Annette M Wons Valentina Rossi Daniel J Bratton Christian Schlatzer Esther I Schwarz Giovanni Camen Malcolm Kohler Simulated Obstructive Sleep Apnea Increases P-Wave Duration and P-Wave Dispersion. PLoS ONE |
| title | Simulated Obstructive Sleep Apnea Increases P-Wave Duration and P-Wave Dispersion. |
| title_full | Simulated Obstructive Sleep Apnea Increases P-Wave Duration and P-Wave Dispersion. |
| title_fullStr | Simulated Obstructive Sleep Apnea Increases P-Wave Duration and P-Wave Dispersion. |
| title_full_unstemmed | Simulated Obstructive Sleep Apnea Increases P-Wave Duration and P-Wave Dispersion. |
| title_short | Simulated Obstructive Sleep Apnea Increases P-Wave Duration and P-Wave Dispersion. |
| title_sort | simulated obstructive sleep apnea increases p wave duration and p wave dispersion |
| url | http://europepmc.org/articles/PMC4829247?pdf=render |
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