Lung cancer incidences after liver transplantation: A systematic review and meta‐analysis
Abstract Background Liver transplantation has made significant progress in recent decades. Lung cancer is one of the most frequently occurring cancers after liver transplantation. However, the risk of lung cancer among liver transplant patients compared with the general population is unclear. The ai...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.6265 |
| _version_ | 1797361192205811712 |
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| author | Chang Fu Xiaocong Li Yongjin Chen Xiaoyin Long Kai Liu |
| author_facet | Chang Fu Xiaocong Li Yongjin Chen Xiaoyin Long Kai Liu |
| author_sort | Chang Fu |
| collection | DOAJ |
| description | Abstract Background Liver transplantation has made significant progress in recent decades. Lung cancer is one of the most frequently occurring cancers after liver transplantation. However, the risk of lung cancer among liver transplant patients compared with the general population is unclear. The aim of this meta‐analysis was to assess the risk of developing lung cancer after liver transplantation. Methods All eligible studies published in PubMed, Web of Science, and Embase from database inception to April 2022 were included. Standardized incidence ratio was used to describe the increased risk of lung cancer in liver transplant recipients as compared with the general population. The random‐effects model was used for the calculations. A funnel plot and Egger test were performed to assess the potential publication bias. Results Our meta‐analysis included 15 studies, which involved 76,897 liver transplantation patients. Studies included in this review showed significant heterogeneity (I2 = 65.3%; p < 0.001), which required a random‐effects model for effect pooling. The results indicated a significant higher risk of developing lung cancer in liver transplant patients than the general population with a pooled SIR of 2.06 (95% CI: 1.73, 2.46, p < 0.001). When stratified by region, no significant regional difference was observed. It showed a similarly doubled risk of lung cancer in Europe and North America, but an insignificantly increased risk in Asian populations. The sensitivity analysis by removal and substitution of each literature did not change the results. Conclusion Our meta‐analysis suggests that liver transplant patients are twice as likely as the general population to develop lung cancer. Further research on risk factors for the development of lung cancer after liver transplantation should be conducted and appropriate surveillance protocols should be developed to reduce the risk of its occurrence. |
| first_indexed | 2024-03-08T15:50:24Z |
| format | Article |
| id | doaj.art-1a74a63009f74d0a86e29db860909abc |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-08T15:50:24Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-1a74a63009f74d0a86e29db860909abc2024-01-09T05:41:08ZengWileyCancer Medicine2045-76342023-08-011215161191612810.1002/cam4.6265Lung cancer incidences after liver transplantation: A systematic review and meta‐analysisChang Fu0Xiaocong Li1Yongjin Chen2Xiaoyin Long3Kai Liu4Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center First Hospital of Jilin University Changchun ChinaMedical Research and Biometrics Center, National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Hepatobiliary and Pancreatic Surgery, General Surgery Center First Hospital of Jilin University Changchun ChinaDepartment of Hepatobiliary and Pancreatic Surgery, General Surgery Center First Hospital of Jilin University Changchun ChinaDepartment of Hepatobiliary and Pancreatic Surgery, General Surgery Center First Hospital of Jilin University Changchun ChinaAbstract Background Liver transplantation has made significant progress in recent decades. Lung cancer is one of the most frequently occurring cancers after liver transplantation. However, the risk of lung cancer among liver transplant patients compared with the general population is unclear. The aim of this meta‐analysis was to assess the risk of developing lung cancer after liver transplantation. Methods All eligible studies published in PubMed, Web of Science, and Embase from database inception to April 2022 were included. Standardized incidence ratio was used to describe the increased risk of lung cancer in liver transplant recipients as compared with the general population. The random‐effects model was used for the calculations. A funnel plot and Egger test were performed to assess the potential publication bias. Results Our meta‐analysis included 15 studies, which involved 76,897 liver transplantation patients. Studies included in this review showed significant heterogeneity (I2 = 65.3%; p < 0.001), which required a random‐effects model for effect pooling. The results indicated a significant higher risk of developing lung cancer in liver transplant patients than the general population with a pooled SIR of 2.06 (95% CI: 1.73, 2.46, p < 0.001). When stratified by region, no significant regional difference was observed. It showed a similarly doubled risk of lung cancer in Europe and North America, but an insignificantly increased risk in Asian populations. The sensitivity analysis by removal and substitution of each literature did not change the results. Conclusion Our meta‐analysis suggests that liver transplant patients are twice as likely as the general population to develop lung cancer. Further research on risk factors for the development of lung cancer after liver transplantation should be conducted and appropriate surveillance protocols should be developed to reduce the risk of its occurrence.https://doi.org/10.1002/cam4.6265liver transplantationlung cancermeta‐analysisstandardized incidence ratio |
| spellingShingle | Chang Fu Xiaocong Li Yongjin Chen Xiaoyin Long Kai Liu Lung cancer incidences after liver transplantation: A systematic review and meta‐analysis Cancer Medicine liver transplantation lung cancer meta‐analysis standardized incidence ratio |
| title | Lung cancer incidences after liver transplantation: A systematic review and meta‐analysis |
| title_full | Lung cancer incidences after liver transplantation: A systematic review and meta‐analysis |
| title_fullStr | Lung cancer incidences after liver transplantation: A systematic review and meta‐analysis |
| title_full_unstemmed | Lung cancer incidences after liver transplantation: A systematic review and meta‐analysis |
| title_short | Lung cancer incidences after liver transplantation: A systematic review and meta‐analysis |
| title_sort | lung cancer incidences after liver transplantation a systematic review and meta analysis |
| topic | liver transplantation lung cancer meta‐analysis standardized incidence ratio |
| url | https://doi.org/10.1002/cam4.6265 |
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